journal article·2025-12-27Open access

Strain-insensitive MXene-based wearable temperature patch with integrated thermoelectric cooling for continuous infant thermal monitoring and in-situ treatment

Xiaojiang Huang, Yuan He, Yunxiang Shi, Yunchao Hao, Yifan Ge, Huiqing Zhang, Peng Li, Feng Xu, Yao Yao

npj Flexible Electronics· Volume 10· Issue 1

Abstract

Continuous and accurate nighttime monitoring of infants’ body temperature is crucial for early fever detection and timely interventions, directly impacting their health. However, existing wearable temperature sensors are often sensitive to body movement-induced strain, causing inaccurate readings, and lack integrated active temperature regulation. Here, we developed a strain-insensitive wearable temperature patch that integrates a flexible MXene-based thermal sensor with a thermoelectric cooling module for continuous monitoring and in-situ cooling treatment. The thermal sensor employs an alternating laminated architecture with interfacial interlocking, incorporating PVA/CNF/MXene/Fe(II) composites, achieving a high strain insensitivity with a gauge factor of 0.5 and high thermosensitivity with a sensitivity of 1.78% °C −1 , a resolution of 0.5 °C, and a rapid response time of 7 s within a 20–70 °C range. Upon fever detection, the cooling module can lower skin temperature by 2 °C. This wearable system provides a practical solution for infant thermal management, potentially enhancing health outcomes.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Thermal Regulation in Medicine · MXene and MAX Phase Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (77)

Show source-provided references
1. Chung, H. U. et al. Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care. Science 363, eaau0780 (2019).10.1126/science.aau0780 ↗
2. Chung, H. U. et al. Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units. Nat. Med. 26, 418–429 (2020).10.1038/s41591-020-0792-9 ↗
3. Yuan, M. et al. Soft electronics for advanced infant monitoring. Mater. Today 75, 166–186 (2024).10.1016/j.mattod.2024.03.005 ↗
4. Yoo, J. Y. et al. Wireless broadband acousto-mechanical sensing system for continuous physiological monitoring. Nat. Med. 29, 3137–3148 (2023).10.1038/s41591-023-02637-5 ↗
5. Inamori, G. et al. Neonatal wearable device for colorimetry-based real-time detection of jaundice with simultaneous sensing of vitals. Sci. Adv. 7, eabe3793 (2021).10.1126/sciadv.abe3793 ↗
6. Rwei, A. Y. et al. A wireless, skin-interfaced biosensor for cerebral hemodynamic monitoring in pediatric care. Proc. Natl Acad. Sci. USA 117, 31674–31684 (2020).10.1073/pnas.2019786117 ↗
7. Xu, K. et al. A wearable body condition sensor system with wireless feedback alarm functions. Adv. Mater. 33, e2008701 (2021).10.1002/adma.202008701 ↗
8. Hong, S. et al. Wearable thermoelectrics for personalized thermoregulation. Sci. Adv. 5, eaaw0536 (2019).10.1126/sciadv.aaw0536 ↗
9. Hu, R. et al. Emerging materials and strategies for personal thermal management. Adv. Energy Mater. 10, 1903921 (2020).10.1002/aenm.201903921 ↗
10. Wu, J. et al. Self-calibrated, sensitive, and flexible temperature sensor based on 3D chemically modified graphene hydrogel. Adv. Electron. Mater. 7, 2001084 (2021).10.1002/aelm.202001084 ↗
11. Wen, B. et al. Reduced graphene oxides: light-weight and high-efficiency electromagnetic interference shielding at elevated temperatures. Adv. Mater. 26, 3484–3489 (2014).10.1002/adma.201400108 ↗
12. Zhang, H. et al. Graphene-enabled wearable sensors for healthcare monitoring. Biosens. Bioelectron. 197, 113777 (2022).10.1016/j.bios.2021.113777 ↗
13. Trung, T. Q., Ramasundaram, S., Hwang, B. U. & Lee, N. E. An all-elastomeric transparent and stretchable temperature sensor for body-attachable wearable electronics. Adv. Mater. 28, 502–509 (2016).10.1002/adma.201504441 ↗
14. Wang, Q. et al. Self-healable multifunctional electronic tattoos based on silk and graphene. Adv. Funct. Mater. 29, 1808695 (2019).10.1002/adfm.201808695 ↗
15. Zhu, C. X. et al. Stretchable temperature-sensing circuits with strain suppression based on carbon nanotube transistors. Nat. Electron. 1, 183–190 (2018).10.1038/s41928-018-0041-0 ↗
16. Honda, W. et al. High-performance, mechanically flexible, and vertically integrated 3D carbon nanotube and InGaZnO complementary circuits with a temperature sensor. Adv. Mater. 27, 4674–4680 (2015).10.1002/adma.201502116 ↗
17. Lee, J. H. et al. Rational design of all resistive multifunctional sensors with stimulus discriminability. Adv. Funct. Mater. 32, 2107570 (2021).10.1002/adfm.202107570 ↗
18. Lin, M. et al. A high-performance, sensitive, wearable multifunctional sensor based on rubber/CNT for human motion and skin temperature detection. Adv. Mater. 34, 2107309 (2022).10.1002/adma.202107309 ↗
19. An, B. W., Heo, S., Ji, S., Bien, F. & Park, J. U. Transparent and flexible fingerprint sensor array with multiplexed detection of tactile pressure and skin temperature. Nat. Commun. 9, 2458 (2018).10.1038/s41467-018-04906-1 ↗
20. Fan, W. et al. An Antisweat Interference and Highly Sensitive Temperature Sensor Based on Poly(3,4-ethylenedioxythiophene)-Poly(styrenesulfonate) Fiber Coated with Polyurethane/Graphene for Real-Time Monitoring of Body Temperature. ACS Nano 17, 21073–21082 (2023).10.1021/acsnano.3c04246 ↗
21. Pradhan, S. & Yadavalli, V. K. Photolithographically printed flexible silk/PEDOT:PSS temperature sensors. ACS Appl. Electron. Mater. 3, 21–29 (2021).10.1021/acsaelm.0c01017 ↗
22. Hong, S. Y. et al. Stretchable active matrix temperature sensor array of polyaniline nanofibers for electronic skin. Adv. Mater. 28, 930–935 (2016).10.1002/adma.201504659 ↗
23. Ge, G. et al. Muscle-inspired self-healing hydrogels for strain and temperature sensor. Acs Nano 14, 218–228 (2020).10.1021/acsnano.9b07874 ↗
24. Bang, J. et al. Highly sensitive temperature sensor: ligand-treated Ag nanocrystal thin films on PDMS with thermal expansion strategy. Adv. Funct. Mater. 29, 1903047 (2019).10.1002/adfm.201903047 ↗
25. He, W. et al. Polypyrrole/silver coaxial nanowire aero-sponges for temperature-independent stress sensing and stress-triggered Joule heating. ACS Nano 9, 4244–4251 (2015).10.1021/acsnano.5b00626 ↗
26. Wu, D. et al. Pt/Zn-TCPP nanozyme-based flexible immunoassay for dual-mode pressure-temperature monitoring of low-abundance proteins. Anal. Chem. 96, 8740–8746 (2024).10.1021/acs.analchem.4c01059 ↗
27. Huang, J. N. et al. Stretchable and heat-resistant protein-based electronic skin for human thermoregulation. Adv. Funct. Mater. 30, 1910547 (2020).10.1002/adfm.201910547 ↗
28. Hua, Q. et al. Skin-inspired highly stretchable and conformable matrix networks for multifunctional sensing. Nat. Commun. 9, 244 (2018).10.1038/s41467-017-02685-9 ↗
29. Li, M. K. et al. Thermally conductive polyvinyl alcohol composite films via introducing hetero-structured MXene@silver fillers. Nano Res. 16, 7820–7828 (2023).10.1007/s12274-023-5594-1 ↗
30. Zhang, S. P. et al. On-skin ultrathin and stretchable multifunctional sensor for smart healthcare wearables. npj Flex. Electron. 6, 11 (2022).10.1038/s41528-022-00140-4 ↗
31. Ge, G. et al. Ti(3)C(2)T(x) MXene-activated fast gelation of stretchable and self-healing hydrogels: a molecular approach. ACS Nano 15, 2698–2706 (2021).10.1021/acsnano.0c07998 ↗
32. Liu, J. L. et al. Intelligent silk fibroin ionotronic skin for temperature sensing. Adv. Mater. Technol. 5, 2000430 (2020).10.1002/admt.202000430 ↗
33. Hao, S. W., Meng, L., Fu, Q. J., Xu, F. & Yang, J. Low-Temperature insensitivity and conformal adhesion zwitterionic hydrogels as electronic skin for strain and temperature responsiveness. Chem. Eng. J. 431, 133782 (2022).10.1016/j.cej.2021.133782 ↗
34. Yu, H. et al. Flexible temperature-pressure dual sensor based on 3D spiral thermoelectric Bi(2)Te(3) films. Nat. Commun. 15, 2521 (2024).10.1038/s41467-024-46836-1 ↗
35. Shin, J. et al. Sensitive wearable temperature sensor with seamless monolithic integration. Adv. Mater. 32, 1905527 (2020).10.1002/adma.201905527 ↗
36. Liu, Q. X. et al. A high-performances flexible temperature sensor composed of polyethyleneimine/reduced graphene oxide bilayer for real-time monitoring. Adv. Mater. Technol. 4, 1800594 (2019).10.1002/admt.201800594 ↗
37. Trung, T. Q. et al. A stretchable strain-insensitive temperature sensor based on free-standing elastomeric composite fibers for on-body monitoring of skin temperature. ACS Appl. Mater. Inter. 11, 2317–2327 (2019).10.1021/acsami.8b19425 ↗
38. Chhetry, A. et al. Black phosphorus@laser-engraved graphene heterostructure-based temperature–strain hybridized sensor for electronic-skin applications. Adv. Funct. Mater. 31, 2007661 (2020).10.1002/adfm.202007661 ↗
39. Zhang, C. et al. Dopamine-triggered hydrogels with high transparency, self-adhesion, and thermoresponse as skinlike sensors. ACS Nano 15, 1785–1794 (2021).10.1021/acsnano.0c09577 ↗
40. Wang, Y. et al. Ti(3)C(2)T(x) MXene-based flexible piezoresistive physical sensors. ACS Nano 16, 1734–1758 (2022).10.1021/acsnano.1c09925 ↗
41. Wang, W. C. et al. Strain-insensitive intrinsically stretchable transistors and circuits. Nat. Electron. 4, 143–150 (2021).10.1038/s41928-020-00525-1 ↗
42. Zhao, Y. et al. Soft strain-insensitive bioelectronics featuring brittle materials. Science 378, 1222–1227 (2022).10.1126/science.abn5142 ↗
43. Li, A. et al. High performance magnesium-based plastic semiconductors for flexible thermoelectrics. Nat. Commun. 15, 5108 (2024).10.1038/s41467-024-49440-5 ↗
44. Powell, A. V., Vaqueiro, P., Tippireddy, S. & Prado-Gonjal, J. Exploiting chemical bonding principles to design high-performance thermoelectric materials. Nat. Rev. Chem. 9, 241–260 (2025).10.1038/s41570-025-00695-6 ↗
45. Zhang, Q. H., Deng, K. F., Wilkens, L., Reith, H. & Nielsch, K. Micro-thermoelectric devices. Nat. Electron. 5, 333–347 (2022).10.1038/s41928-022-00776-0 ↗
46. Mao, J., Chen, G. & Ren, Z. Thermoelectric cooling materials. Nat. Mater. 20, 454–461 (2021).10.1038/s41563-020-00852-w ↗
47. Zhang, S. et al. Solid-state cooling by elastocaloric polymer with uniform chain-lengths. Nat. Commun. 13, 9 (2022).10.1038/s41467-021-27746-y ↗
48. Ma, R. et al. Highly efficient electrocaloric cooling with electrostatic actuation. Science 357, 1130–1134 (2017).10.1126/science.aan5980 ↗
49. Wang, Y. et al. A high-performance solid-state electrocaloric cooling system. Science 370, 129–133 (2020).10.1126/science.aba2648 ↗
50. Moya, X., Kar-Narayan, S. & Mathur, N. D. Caloric materials near ferroic phase transitions. Nat. Mater. 13, 439–450 (2014).10.1038/nmat3951 ↗
51. Kishore, R. A., Nozariasbmarz, A., Poudel, B., Sanghadasa, M. & Priya, S. Ultra-high performance wearable thermoelectric coolers with less materials. Nat. Commun. 10, 1765 (2019).10.1038/s41467-019-09707-8 ↗
52. Deng, Y. et al. Fast Gelation of Ti(3) C(2) T(x) MXene Initiated by Metal Ions. Adv. Mater. 31, 1902432 (2019).10.1002/adma.201902432 ↗
53. He, H. et al. Salt-induced ductilization and strain-insensitive resistance of an intrinsically conducting polymer. Sci. Adv. 8, eabq8160 (2022).10.1126/sciadv.abq8160 ↗
54. Xu, Y. et al. Phase-separated porous nanocomposite with ultralow percolation threshold for wireless bioelectronics. Nat. Nanotechnol. 19, 1158–1167 (2024).10.1038/s41565-024-01658-6 ↗
55. Hao, S., Fu, Q., Meng, L., Xu, F. & Yang, J. A biomimetic laminated strategy enabled strain-interference free and durable flexible thermistor electronics. Nat. Commun. 13, 6472 (2022).10.1038/s41467-022-34168-x ↗
56. Ma, T. et al. A bioinspired interface design for improving the strength and electrical conductivity of graphene-based fibers. Adv. Mater. 30, 1706435 (2018).10.1002/adma.201706435 ↗
57. Sun, W. B. et al. Nacre-inspired bacterial cellulose/mica nanopaper with excellent mechanical and electrical insulating properties by biosynthesis. Adv. Mater. 35, 2300241 (2023).10.1002/adma.202300241 ↗
58. Zhang, X., Wu, K., Ni, Y. & He, L. Anomalous inapplicability of nacre-like architectures as impact-resistant templates in a wide range of impact velocities. Nat. Commun. 13, 7719 (2022).10.1038/s41467-022-35439-3 ↗
59. Liu, H. et al. Approaching intrinsic dynamics of MXenes hybrid hydrogel for 3D printed multimodal intelligent devices with ultrahigh superelasticity and temperature sensitivity. Nat. Commun. 13, 3420 (2022).10.1038/s41467-022-31051-7 ↗
60. Li, X. et al. MXene chemistry, electrochemistry and energy storage applications. Nat. Rev. Chem. 6, 389–404 (2022).10.1038/s41570-022-00384-8 ↗
61. Huang, X. et al. High-stretchability and low-hysteresis strain sensors using origami-inspired 3D mesostructures. Sci. Adv. 9, eadh9799 (2023).10.1126/sciadv.adh9799 ↗
62. Jiang, Y. et al. Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing. Nat. Biotechnol. 41, 652–662 (2023).10.1038/s41587-022-01528-3 ↗
63. Miao, L. et al. Comfortable wearable thermoelectric generator with high output power. Nat. Commun. 15, 8516 (2024).10.1038/s41467-024-52841-1 ↗
64. Yang, Q. et al. Flexible thermoelectrics based on ductile semiconductors. Science 377, 854–858 (2022).10.1126/science.abq0682 ↗
65. Reeder, J. T. et al. Soft, bioresorbable coolers for reversible conduction block of peripheral nerves. Science 377, 109–115 (2022).10.1126/science.abl8532 ↗
66. Urisarri, A. et al. BMP8 and activated brown adipose tissue in human newborns. Nat. Commun. 12, 5274 (2021).10.1038/s41467-021-25456-z ↗
67. Zhang, X. et al. Flexible temperature sensor with high reproducibility and wireless closed-loop system for decoupled multimodal health monitoring and personalized thermoregulation. Adv. Mater. 36, 2407859 (2024).10.1002/adma.202407859 ↗
68. Madhvapathy, S. R. et al. Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation. Nat. Biomed. Eng. 8, 1040–1052 (2024).10.1038/s41551-024-01183-w ↗
69. Zheng, X. T. et al. Battery-free and AI-enabled multiplexed sensor patches for wound monitoring. Sci. Adv. 9, eadg6670 (2023).10.1126/sciadv.adg6670 ↗
70. Chen, X. et al. Non-invasive activation of intratumoural gene editing for improved adoptive T-cell therapy in solid tumours. Nat. Nanotechnol. 18, 933–944 (2023).10.1038/s41565-023-01378-3 ↗
71. Yang, M. Z. et al. Roll-to-roll fabricated polymer composites filled with subnanosheets exhibiting high energy density and cyclic stability at 200 °C. Nat. Energy 9, 143–153 (2024).10.1038/s41560-023-01416-3 ↗
72. Shao, Y. et al. Room-temperature high-precision printing of flexible wireless electronics based on MXene inks. Nat. Commun. 13, 3223 (2022).10.1038/s41467-022-30648-2 ↗
73. Zou, K. et al. Electronic cooling and energy harvesting using ferroelectric polymer composites. Nat. Commun. 15, 6670 (2024).10.1038/s41467-024-51147-6 ↗
74. Liu, C. et al. Multi-Interface Engineering of MXenes for Self-Powered Wearable Devices. Adv. Mater. 36, 2403791 (2024).10.1002/adma.202403791 ↗
75. Zhang, B. et al. Nature-inspired interfacial engineering for energy harvesting. Nat. Rev. Electr. Eng. 1, 218–233 (2024).10.1038/s44287-024-00029-6 ↗
76. Zhang, B. et al. A three-dimensional liquid diode for soft, integrated permeable electronics. Nature 628, 84–92 (2024).10.1038/s41586-024-07161-1 ↗
77. Joyce, P. et al. A translational framework to DELIVER nanomedicines to the clinic. Nat. Nanotechnol. 19, 1597–1611 (2024).10.1038/s41565-024-01754-7 ↗