A review of sampling, energy supply and intelligent monitoring for long-term sweat sensors
Source abstract
Abstract
Abstract Sweat is a biofluid with rich information that can reflect an individual’s state of health or activity. But the real-time in situ sweat sensors lack the ability of long-term monitoring. Against this background, this article provides a holistic review on the necessary process and methods for sweat sensing, including sweat collection, composition analysis, energy supply, and data processing. The impacts of the environment in stimulating sweat production, providing energy supply, and intelligent health monitoring are discussed. Based on the review of previous endeavors, the future development in material, structure and artificial intelligence application of long-term sweat monitoring is envisioned.
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Research context
OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Tactile and Sensory Interactions · Dielectric materials and actuators
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
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1. Windmiller, J. R. & Wang, J. Wearable Electrochemical Sensors and Biosensors: A Review. Electroanalysis 25, 29–46 (2013).10.1002/elan.201200349 ↗
2. Chen, Y. et al. Flex. Inorg. Bioelectron. npj Flex. Electron. 4, 1–20 (2020).10.1038/s41528-020-0064-2 ↗
3. Wilson, E. K. Wearable Sweat Sensors. Engineering 5, 359–360 (2019).10.1016/j.eng.2019.04.008 ↗
4. Bhide, A., Muthukumar, S. & Prasad, S. CLASP (Continuous lifestyle awareness through sweat platform): A novel sensor for simultaneous detection of alcohol and glucose from passive perspired sweat. Biosens. Bioelectron. 117, 537–545 (2018).10.1016/j.bios.2018.06.065 ↗
5. Nyein, H. Y. Y. et al. A wearable patch for continuous analysis of thermoregulatory sweat at rest. Nat. Commun. 12, 1823 (2021).10.1038/s41467-021-22109-z ↗
6. Lou, Z., Wang, L., Jiang, K., Wei, Z. & Shen, G. Reviews of wearable healthcare systems: Materials, devices and system integration. Mater. Sci. Eng. R. Rep. 140, 100523 (2020).10.1016/j.mser.2019.100523 ↗
7. Burklund, A., Tadimety, A., Nie, Y., Hao, N. & Zhang, J. X. J. Advances in diagnostic microfluidics. in Advances in clinical chemistry 95 1–72 (Elsevier Inc., 2020).10.1016/bs.acc.2019.08.001 ↗
8. Seo, S. E. et al. Smartphone with optical, physical, and electrochemical nanobiosensors. J. Ind. Eng. Chem. 77, 1–11 (2019).10.1016/j.jiec.2019.04.037 ↗
9. Ray, T. R. et al. Bio-integrated wearable systems: A comprehensive review. Chem. Rev. 119, 5461–5533 (2019).10.1021/acs.chemrev.8b00573 ↗
10. Sempionatto, J. R., Jeerapan, I., Krishnan, S. & Wang, J. Wearable Chemical Sensors: Emerging Systems for On-Body Analytical Chemistry. Anal. Chem. 92, 378–396 (2019).10.1021/acs.analchem.9b04668 ↗
11. Chung, M., Fortunato, G. & Radacsi, N. Wearable flexible sweat sensors for healthcare monitoring: A review. J. R. Soc. Interface 16, 20190217 (2019).10.1098/rsif.2019.0217 ↗
12. Li, S., Ma, Z., Cao, Z., Pan, L. & Shi, Y. Advanced Wearable Microfluidic Sensors for Healthcare Monitoring. Small 16, 1903822 (2020).10.1002/smll.201903822 ↗
13. Xu, J., Fang, Y. & Chen, J. Wearable biosensors for non-invasive sweat diagnostics. Biosensors 11, 245 (2021).10.3390/bios11080245 ↗
14. Cuartero, M., Parrilla, M. & Crespo, G. Wearable Potentiometric Sensors for Medical Applications. Sensors 19, 363 (2019).10.3390/s19020363 ↗
15. Liu, Y., Pharr, M. & Salvatore, G. A. Lab-on-Skin: A Review of Flexible and Stretchable Electronics for Wearable Health Monitoring. ACS Nano 11, 9614–9635 (2017).10.1021/acsnano.7b04898 ↗
16. Jo, S., Sung, D., Kim, S. & Koo, J. A review of wearable biosensors for sweat analysis. Biomed. Eng. Lett. 11, 117–129 (2021).10.1007/s13534-021-00191-y ↗
17. Upasham, S., Churcher, N. K. M., Rice, P. & Prasad, S. Sweating out the Circadian Rhythm: A Technical Review. ACS Sens. 6, 659–672 (2021).10.1021/acssensors.0c02622 ↗
18. Klimuntowski, M., Alam, M. M., Singh, G. & Howlader, M. M. R. Electrochemical Sensing of Cannabinoids in Biofluids: A Noninvasive Tool for Drug Detection. ACS Sens. 5, 620–636 (2020).10.1021/acssensors.9b02390 ↗
19. Oktavius, A. K. et al. Fully-Conformable Porous Polyethylene Nanofilm Sweat Sensor for Sports Fatigue. IEEE Sens. J. 21, 8861–8867 (2021).10.1109/JSEN.2021.3054989 ↗
20. Pali, M. et al. Tracking metabolic responses based on macronutrient consumption: A comprehensive study to continuously monitor and quantify dual markers (cortisol and glucose) in human sweat using WATCH sensor. Bioeng. Transl. Med. 6, e10241 (2021).10.1002/btm2.10241 ↗
21. Lee, J. W. et al. Soft, thin skin-mounted power management systems and their use in wireless thermography. Proc. Natl Acad. Sci. USA. 113, 6131–6136 (2016).10.1073/pnas.1605720113 ↗
22. Yeung, K. K. et al. Recent Advances in Electrochemical Sensors for Wearable Sweat Monitoring: A Review. IEEE Sens. J. 21, 14522–14539 (2021).10.1109/JSEN.2021.3074311 ↗
23. Kaya, T. et al. Wearable Sweat Sensors: Background and Current Trends. Electroanalysis 31, 411–421 (2019).10.1002/elan.201800677 ↗
24. Bandodkar, A. J., Jeang, W. J., Ghaffari, R. & Rogers, J. A. Wearable Sensors for Biochemical Sweat Analysis. Annu. Rev. Anal. Chem. 12, 1–22 (2019).10.1146/annurev-anchem-061318-114910 ↗
25. Kwon, J. Y., Park, H. W., Park, Y., Bin & Kim, N. Potentials of additive manufacturing with smart materials for chemical biomarkers in wearable applications. Int. J. Precis. Eng. Manuf. - Green. Technol. 4, 335–347 (2017).10.1007/s40684-017-0039-5 ↗
26. Manjakkal, L., Yin, L., Nathan, A., Wang, J. & Dahiya, R. Energy Autonomous Sweat-Based Wearable Systems. Adv. Mater. 33, 2100899 (2021).10.1002/adma.202100899 ↗
27. Sekar, M. et al. Review—Towards Wearable Sensor Platforms for the Electrochemical Detection of Cortisol. J. Electrochem. Soc. 167, 067508 (2020).10.1149/1945-7111/ab7e24 ↗
28. Matzeu, G., Florea, L. & Diamond, D. Advances in wearable chemical sensor design for monitoring biological fluids. Sensors Actuators. B Chem. 211, 403–418 (2015).
29. McCaul, M., Glennon, T. & Diamond, D. Challenges and opportunities in wearable technology for biochemical analysis in sweat. Curr. Opin. Electrochem 3, 46–50 (2017).10.1016/j.coelec.2017.06.001 ↗
30. Yang, Y. & Gao, W. Wearable and flexible electronics for continuous molecular monitoring. Chem. Soc. Rev. 48, 1465–1491 (2019).10.1039/C7CS00730B ↗
31. Jin, H., Abu-Raya, Y. S. & Haick, H. Advanced Materials for Health Monitoring with Skin-Based Wearable Devices. Adv. Healthc. Mater. 6, 1700024 (2017).10.1002/adhm.201700024 ↗
32. Li, G. & Wen, D. Wearable biochemical sensors for human health monitoring: sensing materials and manufacturing technologies. J. Mater. Chem. B 8, 3423–3436 (2020).10.1039/C9TB02474C ↗
33. Fan, R. & Andrew, T. L. Perspective—Challenges in Developing Wearable Electrochemical Sensors for Longitudinal Health Monitoring. J. Electrochem. Soc. 167, 037542 (2020).10.1149/1945-7111/ab67b0 ↗
34. Gao, W., Brooks, G. A. & Klonoff, D. C. Wearable physiological systems and technologies for metabolic monitoring. J. Appl. Physiol. 124, 548–556 (2018).10.1152/japplphysiol.00407.2017 ↗
35. Yokus, B. M. A. & Daniele, M. A. Integrated non-invasive biochemical and biophysical sensing systems for health and performance monitoring: A systems perspective. Biosens. Bioelectron. 184, 113249 (2021).10.1016/j.bios.2021.113249 ↗
36. Wang, X., Liu, Z. & Zhang, T. Flexible Sensing Electronics for Wearable/Attachable Health Monitoring. Small 13, 1602790 (2017).10.1002/smll.201602790 ↗
37. Hatamie, A. et al. Review—Textile Based Chemical and Physical Sensors for Healthcare Monitoring. J. Electrochem. Soc. 167, 037546 (2020).10.1149/1945-7111/ab6827 ↗
38. Kim, J., Campbell, A. S., de Ávila, B. E. F. & Wang, J. Wearable biosensors for healthcare monitoring. Nat. Biotechnol. 37, 389–406 (2019).10.1038/s41587-019-0045-y ↗
39. Ray, T. et al. Soft, skin-interfaced wearable systems for sports science and analytics. Curr. Opin. Biomed. Eng. 9, 47–56 (2019).10.1016/j.cobme.2019.01.003 ↗
40. Ye, S., Feng, S., Huang, L. & Bian, S. Recent Progress in Wearable Biosensors: From Healthcare Monitoring to Sports Analytics. Biosensors 10, 205 (2020).10.3390/bios10120205 ↗
41. Kim, S. et al. Soft, skin-interfaced microfluidic systems with integrated immunoassays, fluorometric sensors, and impedance measurement capabilities. Proc. Natl Acad. Sci. USA. 117, 27906–27915 (2020).10.1073/pnas.2012700117 ↗
42. Wang, L., Xu, T. & Zhang, X. Multifunctional conductive hydrogel-based flexible wearable sensors. TrAC - Trends Anal. Chem. 134, 116130 (2021).10.1016/j.trac.2020.116130 ↗
43. Rabost-Garcia, G., Farré-Lladós, J. & Casals-Terré, J. Recent Impact of Microfluidics on Skin Models for Perspiration Simulation. Membr. (Basel) 11, 150 (2021).10.3390/met11010150 ↗
44. Yu, H. & Sun, J. Sweat detection theory and fluid driven methods: A review. Nanotechnol. Precis. Eng. 3, 126–140 (2020).10.1016/j.npe.2020.08.003 ↗
45. Kalkal, A. et al. Recent advances in 3D printing technologies for wearable (bio)sensors. Addit. Manuf. 46, 102088 (2021).
46. Sarwar, M., Rodriguez, P. & Li, C. zhong. Sweat-Based in Vitro Diagnostics (IVD): From Sample Collection to Point-of-Care Testing (POCT). J. Anal. Test. 3, 80–88 (2019).10.1007/s41664-019-00097-w ↗
47. Heikenfeld, J. et al. Accessing analytes in biofluids for peripheral biochemical monitoring. Nat. Biotechnol. 37, 407–419 (2019).10.1038/s41587-019-0040-3 ↗
48. Shetti, N. P. et al. Skin-Patchable Electrodes for Biosensor Applications: A Review. ACS Biomater. Sci. Eng. 6, 1823–1835 (2020).10.1021/acsbiomaterials.9b01659 ↗
49. Wen, F. et al. Advances in chemical sensing technology for enabling the next-generation self-sustainable integrated wearable system in the IoT era. Nano Energy 78, 105155 (2020).10.1016/j.nanoen.2020.105155 ↗
50. Shitanda, I. & Tsujimura, S. Toward self-powered real-Time health monitoring of body fluid components based on improved enzymatic biofuel cells. JPhys Energy 3, 032002 (2021).10.1088/2515-7655/abebcb ↗
51. Rao, J. et al. Recent Progress in Self-Powered Skin. Sens. Sens. 19, 2763 (2019).10.3390/s19122763 ↗
52. Jin, X., Liu, C., Xu, T., Su, L. & Zhang, X. Artificial intelligence biosensors: Challenges and prospects. Biosens. Bioelectron. 165, 112412 (2020).10.1016/j.bios.2020.112412 ↗
53. Nguyen, B., Coelho, Y., Bastos, T. & Krishnan, S. Trends in human activity recognition with focus on machine learning and power requirements. Mach. Learn. Appl 5, 100072 (2021).
54. Witt, D. R., Kellogg, R. A., Snyder, M. P. & Dunn, J. Windows into human health through wearables data analytics. Curr. Opin. Biomed. Eng. 9, 28–46 (2019).10.1016/j.cobme.2019.01.001 ↗
55. Morris, D. et al. Bio-sensing textile based patch with integrated optical detection system for sweat monitoring. Sensors Actuators. B Chem. 139, 231–236 (2009).
56. Gao, W. et al. Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. Nature 529, 509–514 (2016).10.1038/nature16521 ↗
57. Heikenfeld, J. Non-invasive Analyte Access and Sensing through Eccrine Sweat: Challenges and Outlook circa 2016. Electroanalysis 28, 1242–1249 (2016).10.1002/elan.201600018 ↗
58. Liu, C., Xu, T., Wang, D. & Zhang, X. The role of sampling in wearable sweat sensors. Talanta 212, 120801 (2020).10.1016/j.talanta.2020.120801 ↗
59. Tankasala, D. & Linnes, J. C. Noninvasive glucose detection in exhaled breath condensate. Transl. Res. 213, 1–22 (2019).10.1016/j.trsl.2019.05.006 ↗
60. Emaminejad, S. et al. Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform. Proc. Natl Acad. Sci. USA. 114, 4625–4630 (2017).10.1073/pnas.1701740114 ↗
61. Kim, J. et al. Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System. ACS Sens. 1, 1011–1019 (2016).10.1021/acssensors.6b00356 ↗
62. Bandodkar, A. J. et al. Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring. Biosens. Bioelectron. 54, 603–609 (2014).10.1016/j.bios.2013.11.039 ↗
63. Son, J. et al. Cactus-Spine-Inspired Sweat-Collecting Patch for Fast and Continuous Monitoring of Sweat. Adv. Mater. 33, 2102740 (2021).10.1002/adma.202102740 ↗
64. Dai, B. et al. Bioinspired Janus Textile with Conical Micropores for Human Body Moisture and Thermal Management. Adv. Mater. 31, 1904113 (2019).10.1002/adma.201904113 ↗
65. He, X. et al. Flexible and Superwettable Bands as a Platform toward Sweat Sampling and Sensing. Anal. Chem. 91, 4296–4300 (2019).10.1021/acs.analchem.8b05875 ↗
66. He, X. et al. Integrated Smart Janus Textile Bands for Self-Pumping Sweat Sampling and Analysis. ACS Sens. 5, 1548–1554 (2020).10.1021/acssensors.0c00563 ↗
67. He, X., Fan, C., Xu, T. & Zhang, X. Biospired Janus Silk E-Textiles with Wet-Thermal Comfort for Highly Efficient Biofluid Monitoring. Nano Lett. 21, 8880–8887 (2021).10.1021/acs.nanolett.1c03426 ↗
68. Choi, J. et al. Soft, skin-mounted microfluidic systems for measuring secretory fluidic pressures generated at the surface of the skin by eccrine sweat glands. Lab Chip 17, 2572–2580 (2017).10.1039/C7LC00525C ↗
69. Choi, J., Kang, D., Han, S., Kim, S. B. & Rogers, J. A. Thin, Soft, Skin-Mounted Microfluidic Networks with Capillary Bursting Valves for Chrono-Sampling of Sweat. Adv. Healthc. Mater. 6, 1601355 (2017).10.1002/adhm.201601355 ↗
70. Samson, C. & Koh, A. Stress Monitoring and Recent Advancements in Wearable Biosensors. Front. Bioeng. Biotechnol. 8, 1037 (2020).10.3389/fbioe.2020.01037 ↗
71. Wang, L., Xu, T., He, X. & Zhang, X. Flexible, self-healable, adhesive and wearable hydrogel patch for colorimetric sweat detection. J. Mater. Chem. C. 9, 14938–14945 (2021).10.1039/D1TC03905A ↗
72. Yang, Y. & Gao, W. Wearable pH sensing beyond the Nernst limit. Nat. Electron. 1, 580–581 (2018).10.1038/s41928-018-0166-1 ↗
73. Nyein, H. Y. Y. et al. A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca2+ and pH. ACS Nano 10, 7216–7224 (2016).10.1021/acsnano.6b04005 ↗
74. Zhai, Q. et al. Vertically Aligned Gold Nanowires as Stretchable and Wearable Epidermal Ion-Selective Electrode for Noninvasive Multiplexed Sweat Analysis. Anal. Chem. 92, 4647–4655 (2020).10.1021/acs.analchem.0c00274 ↗
75. O’Sullivan, B. P. & Freedman, S. D. Cystic fibrosis. Lancet 373, 1891–1904 (2009).10.1016/S0140-6736(09)60327-5 ↗
76. Baker, L. B. Sweating Rate and Sweat Sodium Concentration in Athletes: A Review of Methodology and Intra/Interindividual Variability. Sport. Med. 47, 111–128 (2017).10.1007/s40279-017-0691-5 ↗
77. Parrilla, M., Cuartero, M. & Crespo, G. A. Wearable potentiometric ion sensors. TrAC - Trends Anal. Chem. 110, 303–320 (2019).10.1016/j.trac.2018.11.024 ↗
78. Keene, S. T. et al. Wearable Organic Electrochemical Transistor Patch for Multiplexed Sensing of Calcium and Ammonium Ions from Human Perspiration. Adv. Healthc. Mater. 8, e1901321 (2019).10.1002/adhm.201901321 ↗
79. Jia, W. et al. Electrochemical tattoo biosensors for real-time noninvasive lactate monitoring in human perspiration. Anal. Chem. 85, 6553–6560 (2013).10.1021/ac401573r ↗
80. Alvear-Ordenes, I., García-López, D., De Paz, J. A. & González-Gallego, J. Sweat Lactate, Ammonia, and Urea in Rugby Players. Int. J. Sports Med. 26, 632–637 (2005).10.1055/s-2004-830380 ↗
81. Lamont, L. S. Sweat lactate secretion during exercise in relation to women’s aerobic capacity. J. Appl. Physiol. 62, 194–198 (1987).10.1152/jappl.1987.62.1.194 ↗
82. Wang, R., Zhai, Q., An, T., Gong, S. & Cheng, W. Stretchable gold fiber-based wearable textile electrochemical biosensor for lactate monitoring in sweat. Talanta 222, 121484 (2021).10.1016/j.talanta.2020.121484 ↗
83. Zhou, W. et al. Recent advances in flexible sweat glucose biosensors. J. Phys. D. Appl. Phys. 54, 423001 (2021).10.1088/1361-6463/ac14ef ↗
84. Yunos, M. F. A. M. & Nordin, A. N. Non-invasive glucose monitoring devices: A review. Bull. Electr. Eng. Inform. 9, 2609–2618 (2020).10.11591/eei.v9i6.2628 ↗
85. Zhao, Y. et al. Highly Stretchable and Strain-Insensitive Fiber-Based Wearable Electrochemical Biosensor to Monitor Glucose in the Sweat. Anal. Chem. 91, 6569–6576 (2019).10.1021/acs.analchem.9b00152 ↗
86. Yang, Y. et al. A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat. Nat. Biotechnol. 38, 217–224 (2020).10.1038/s41587-019-0321-x ↗
87. Russell, E., Koren, G., Rieder, M. & Van Uum, S. H. M. The detection of cortisol in human sweat: Implications for measurement of cortisol in hair. Ther. Drug Monit. 36, 30–34 (2014).10.1097/FTD.0b013e31829daa0a ↗
88. Raul, J. S., Cirimele, V., Ludes, B. & Kintz, P. Detection of physiological concentrations of cortisol and cortisone in human hair. Clin. Biochem. 37, 1105–1111 (2004).10.1016/j.clinbiochem.2004.02.010 ↗
89. Torrente-Rodríguez, R. M. et al. Investigation of Cortisol Dynamics in Human Sweat Using a Graphene-Based Wireless mHealth System. Matter 2, 921–937 (2020).10.1016/j.matt.2020.01.021 ↗
90. Tai, L. C. et al. Methylxanthine Drug Monitoring with Wearable Sweat Sensors. Adv. Mater. 30, 1707442 (2018).10.1002/adma.201707442 ↗
91. Gamella, M. et al. A novel non-invasive electrochemical biosensing device for in situ determination of the alcohol content in blood by monitoring ethanol in sweat. Anal. Chim. Acta 806, 1–7 (2014).10.1016/j.aca.2013.09.020 ↗
92. Davis-Martin, R. E., Alessi, S. M. & Boudreaux, E. D. Alcohol Use Disorder in the Age of Technology: A Review of Wearable Biosensors in Alcohol Use Disorder Treatment. Front. Psychiatry 12, 642813 (2021).10.3389/fpsyt.2021.642813 ↗
93. Cao, Z. et al. Near-Field Communication. Sens. Sens. 19, 3947 (2019).10.3390/s19183947 ↗
94. Xu, G. et al. Smartphone-based battery-free and flexible electrochemical patch for calcium and chloride ions detections in biofluids. Sens. Actuators B Chem. 297, 126743 (2019).10.1016/j.snb.2019.126743 ↗
95. Bandodkar, A. J. et al. Soft, stretchable, high power density electronic skin-based biofuel cells for scavenging energy from human sweat. Energy Environ. Sci. 10, 1581–1589 (2017).10.1039/C7EE00865A ↗
96. Reid, R. C. & Mahbub, I. Wearable self-powered biosensors. Curr. Opin. Electrochem 19, 55–62 (2020).10.1016/j.coelec.2019.10.002 ↗
97. Liu, W., Song, M.-S., Kong, B. & Cui, Y. Flexible and Stretchable Energy Storage: Recent Advances and Future Perspectives. Adv. Mater. 29, 1603436 (2017).10.1002/adma.201603436 ↗
98. Wang, Z. et al. Fully transient stretchable fruit‐based battery as safe and environmentally friendly power source for wearable electronics. EcoMat 3, e12073 (2021).10.1002/eom2.12073 ↗
99. He, J. et al. Scalable production of high-performing woven lithium-ion fibre batteries. Nature 597, 57–63 (2021).10.1038/s41586-021-03772-0 ↗
100. Yin, L. et al. A passive perspiration biofuel cell: High energy return on investment. Joule 5, 1888–1904 (2021).10.1016/j.joule.2021.06.004 ↗