Poly(DL-lactide-co-ε-caprolactone) and poly(DL-lactide-co-glycolide) blends for biomedical application: Physical properties, cell compatibility, and in vitro degradation behavior
Source abstract
Abstract
Poly(DL-lactide-co-ε-caprolactone) (PLCL) and poly(DL-lactide-co-glycolide) (PLGA) blends of various compositions were prepared. Fractured sections of PLCL/PLGA blends did not evidence phase separation and blend glass transition temperatures suggested some degree of blend compatibility. The elastic modulus showed a negative deviation from the additive law of mixture. Superior biocompatibility in terms of fibroblast NIH 3T3 cell adhesion and proliferation, better mechanical properties, and a more homogeneous phase were obtained with PLCL/PLGA 25/75 blend. Rapid degradation of PLCL phase (4–8 weeks) in PLCL/PLGA 25/75 blend led to a porous structure, which makes it a potential candidate for drug delivery systems.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: biodegradable polymer synthesis and properties · Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Torino, Italy
Department of Biomedical Engineering, McGill University, Montreal, Quebec, Canada
School of Mechanical and Systems Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom
Funding
This work was supported by the BIO-PATH (MANUNET ERA-NET) and B-BARRIER (MI.S.E.-ICE-CRUI) projects.
References (44)
Show source-provided references
1. 10.1177/10711007970180030310.1177/107110079701800303 ↗
2. Vaquette C. · Biomed. Mater. Eng · 2006 · 16 · S131
3. 10.1016/j.colsurfb.2009.09.00110.1016/j.colsurfb.2009.09.001 ↗
4. 10.1016/j.polymer.2008.09.01410.1016/j.polymer.2008.09.014 ↗
5. 10.1016/S0010-7824(03)00136-710.1016/S0010-7824(03)00136-7 ↗
6. Tonda-Turo C. · Adv. Eng. Mater · 2011 · 13 · B15110.1002/adem.201080099 ↗
7. Yu N. Y. C. · Eur. Cells Mater · 2010 · 20 · 43110.22203/eCM.v020a35 ↗
8. 10.1016/j.biomaterials.2010.02.02810.1016/j.biomaterials.2010.02.028 ↗
9. 10.1016/j.biotechadv.2011.06.01910.1016/j.biotechadv.2011.06.019 ↗
10. 10.1002/polb.2225910.1002/polb.22259 ↗
11. 10.1016/j.polymdegradstab.2012.03.01410.1016/j.polymdegradstab.2012.03.014 ↗
12. 10.1002/adhm.20140042410.1002/adhm.201400424 ↗
13. 10.1007/s10853-009-4080-910.1007/s10853-009-4080-9 ↗
14. 10.1016/j.matchemphys.2007.02.08010.1016/j.matchemphys.2007.02.080 ↗
15. 10.1208/s12249-011-9714-y10.1208/s12249-011-9714-y ↗
16. 10.1016/j.biomaterials.2008.08.03110.1016/j.biomaterials.2008.08.031 ↗
17. 10.1002/jbm.a.1015710.1002/jbm.a.10157 ↗
18. 10.1016/j.actbio.2010.08.01910.1016/j.actbio.2010.08.019 ↗
19. 10.1016/j.dental.2012.04.02210.1016/j.dental.2012.04.022 ↗
20. 10.1002/jbm.82029121510.1002/jbm.820291215 ↗
21. 10.1002/jbm.a.1045310.1002/jbm.a.10453 ↗
22. 10.1089/10763270332206661510.1089/107632703322066615 ↗
23. 10.1002/(SICI)1097-4636(19981205)42:3<417::AID-JBM11>3.0.CO;2-D10.1002/(SICI)1097-4636(19981205)42:3<417::AID-JBM11>3.0.CO;2-D ↗
24. Wu X. S. · 1995
25. 10.1007/s10965-009-9292-910.1007/s10965-009-9292-9 ↗
26. Askeland D. R. · 1996
27. Fox T. · Bull. Am. Phys. Soc · 1956 · 1 · 123
28. 10.1126/science.111699510.1126/science.1116995 ↗
29. 10.1002/cm.2004110.1002/cm.20041 ↗
30. 10.1002/1097-4636(200011)52:2<279::AID-JBM6>3.0.CO;2-810.1002/1097-4636(200011)52:2<279::AID-JBM6>3.0.CO;2-8 ↗
31. 10.1002/jbm.a.3179610.1002/jbm.a.31796 ↗
32. 10.1002/jbm.103810.1002/jbm.1038 ↗
33. 10.1111/j.1600-0757.2005.00141.x10.1111/j.1600-0757.2005.00141.x ↗
34. 10.1016/j.eurpolymj.2007.06.01610.1016/j.eurpolymj.2007.06.016 ↗
35. 10.1002/app.117210.1002/app.1172 ↗
36. 10.1016/0142-9612(91)90014-210.1016/0142-9612(91)90014-2 ↗
37. 10.1016/j.biomaterials.2004.01.05710.1016/j.biomaterials.2004.01.057 ↗
38. 10.1007/978-3-642-77563-5_610.1007/978-3-642-77563-5_6 ↗
39. 10.1002/app.2388810.1002/app.23888 ↗
40. 10.1002/(SICI)1097-4636(199908)46:2<236::AID-JBM13>3.0.CO;2-F10.1002/(SICI)1097-4636(199908)46:2<236::AID-JBM13>3.0.CO;2-F ↗
41. 10.1007/978-1-4899-3176-410.1007/978-1-4899-3176-4 ↗
42. 10.1016/j.jconrel.2005.07.00910.1016/j.jconrel.2005.07.009 ↗
43. 10.1016/j.polymer.2009.05.03510.1016/j.polymer.2009.05.035 ↗
44. 10.1016/j.ejpb.2009.11.01210.1016/j.ejpb.2009.11.012 ↗