Application of stem cells, growth factors, small molecules, and biological macromolecules on nerve regeneration: a review and future direction

Saba Nemati Mahand; Niloofar Niknami; Armaghan Moghaddam; Sogand Nemati Mahand; Abolfazl Salehi Moghaddam; Mohammad Arjmand; Franziska Alt; Benjamin Kruppke; Hossein Ali Khonakdar

doi:10.1080/00914037.2023.2215376

journal article·2024-06-12

Application of stem cells, growth factors, small molecules, and biological macromolecules on nerve regeneration: a review and future direction

Saba Nemati Mahand, Niloofar Niknami, Armaghan Moghaddam, Sogand Nemati Mahand, Abolfazl Salehi Moghaddam, Mohammad Arjmand, Franziska Alt, Benjamin Kruppke, Hossein Ali Khonakdar

International Journal of Polymeric Materials and Polymeric Biomaterials· Volume 73· Issue 9

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Source abstract

Abstract

The nervous system is a vital component of the human body, and its dysfunction can have fatal consequences or severe adverse effects. After significant disabling conditions, the nervous system is not able to recover damaged parts. Schwann cells are needed in a short period to regenerate nerve cells, but they do not support axonal growth-permissive phenotype. In this regard, implanting growth factors, small molecules, stem cells, and biological macromolecules in peripheral nerve injury would promote axonal outgrowth. In this review, the nervous system, related injuries, and essential factors applied for nerve regeneration are systematically highlighted.

Source: openalex_inverted_index · Quality: baseline

Research context

Polymers Biomaterials

OpenAlex topics: Nerve injury and regeneration · Graphene and Nanomaterials Applications · Pluripotent Stem Cells Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Polymer Processing, Iran Polymer and Petrochemical Institute, Tehran 14965-115, Iran

Shahid Beheshti University, Tehran, Iran

Lehigh University, Bethlehem, PA, USA

Nanomaterials and Polymer Nanocomposites Laboratory, School of Engineering, University of British Columbia, Kelowna, Canada

Max Bergmann Center of Biomaterials, Institute of Materials Science, Technische Universität Dresden, 01069 Dresden, Germany

Leibniz Institute of Polymer Research Dresden, Dresden, Germany

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