Assessment of formulation parameters needed for successful vitamin C entrapped polycaprolactone nanoparticles
Source abstract
Abstract
Vitamin C (Vit.C)-entrapped polycaprolactone (PCL) nanoparticles (Vit.C–PCNs) were prepared by encapsulation of Vit.C into PCL-based nanoparticles (PCNs) which were prepared using double emulsion method with two steps. First, the inner aqueous phase (W1) was added to dichloromethane solution containing PCL with homogenization to form primary emulsion (W1/O) which was emulsified with the outer aqueous phase (W2) containing polyvinyl alcohol as stabilizer to attain the double emulsion (W1/O/W2). Versatile parameters were investigated to reach to the most successful formulation for Vit.C–PCNs, such as time, effect of speed of homogenization on drug encapsulation efficiency, etc.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Drug Delivery Systems · Nanoparticle-Based Drug Delivery · Surfactants and Colloidal Systems
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Polymers and Pigments Department, National Research Centre, Giza, Egypt
Pharmaceutical technology Department, National Research Centre, Giza, Egypt
Chemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt
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