Preparation of physically crosslinked PVA/HLC/SA hydrogel and exploration of its effects on full-thickness skin defects
Source abstract
Abstract
In this study, single factor experiments and orthogonal test were designed to fabricate a novel poly(vinyl alcohol) (PVA), human-like collagen (HLC) and sodium alginate (SA) composite hydrogel as wound dressings. The obtained hydrogel dressing was soft, elastic and breathable with uniform macro pores, and it remains soft after lyophilization which restore to the original appearance after absorbing a large amount of water. In vivo full-thickness skin defects treated with the hydrogel dressings in rabbit revealed that the hydrogel promoted wound healing through accelerating reepithelization and the growth of collagen fibers. All the results demonstrated the great potential of the hydrogel as wound dressing.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Wound Healing and Treatments · Electrospun Nanofibers in Biomedical Applications · Surgical Sutures and Adhesives
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi’an, China;
Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi’an, China;
Biotech. & Biomed. Reserch Institute, Northwest University, Xi’an, China
Funding
National Natural Science Foundation of China · Shaanxi Key Laboratory of Degradable Biomedical Materials Program
References (25)
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