journal article·2021-08

Research progress on the biomedical uses of graphene and its derivatives

Yang Liu, Jing Ding, Qi-qi Wang, Mei-ling Wen, Ting-ting Tang, Yong Liu, Rong Yuan, Yong-feng Li, Mei-wen An

New Carbon Materials· Volume 36· Issue 4
Publisher page

Abstract

Graphene (Gr) is a monolayer of carbon atoms in a two-dimensional honeycomb lattice, and has derivatives of graphene oxide and reduced graphene oxide. Gr is widely used in various fields for its good optics, conductivity, mechanical properties, low toxicity, antibacterial properties, biocompatibility and stability. Graphene oxide and reduced graphene oxide have similar properties to Gr, and all three materials have advantages and disadvantages and are often not used alone but are composited with other materials to improve their properties for a particular application. From the perspectives of the toxicity and antibacterial properties of Gr and its derivatives, this paper reviews their uses in treating skin wounds and tumours, promoting the regeneration of skeletal muscle and bone, and facilitating drug loading and diagnosis. The problems associated with these applications are analyzed and solutions are suggested. Future research and development prospects for Gr-based materials are presented.
Source: expertdata · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Graphene and Nanomaterials Applications · Bone Tissue Engineering Materials · Nanoparticles: synthesis and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (100+)

Show source-provided references
1. Graphene toxicity as a double-edged sword of risks and exploitable opportunities: a critical analysis of the most recent trends and developments [J]10.1088/2053-1583/aa5476 ↗
2. Wang · 2012
3. Chen · 2013
4. Cytotoxicity of graphene oxide and graphene in human erythrocytes and skin fibroblasts [J]10.1021/am200428v ↗
5. Microcarbon-based facial creams activate aerial oxygen under light to reactive oxygen species damaging cell [J]10.1007/s13204-017-0604-9 ↗
6. No cytotoxicity or genotoxicity of graphene and graphene oxide in murine lung epithelial FE1 cells in vitro [J]10.1002/em.22017 ↗
7. Comparative in vitro toxicity of a graphene oxide-silver nanocomposite and the pristine counterparts toward macrophages [J]10.1186/s12951-016-0165-1 ↗
8. Synergistic effect of carbon nanotubes and graphene for high performance cellulose acetate membranes in biomedical applications [J]10.1016/j.carbpol.2017.10.095 ↗
9. Functionalization of reduced graphene oxide with polysulfone brushes enhance antibacterial properties and reduce human cytotoxicity [J]10.1016/j.carbon.2016.10.005 ↗
10. The rational designed graphene oxide-Fe2O3 composites with low cytotoxicity [J]10.1016/j.msec.2016.11.130 ↗
11. Toxicity of nanomaterials: exposure, pathways, assessment, and recent advances [J]10.1021/acsbiomaterials.8b00068 ↗
12. One-step green hydrothermal synthesis of biocompatible graphene/TiO2 nanocomposites for non-enzymatic H2O2 detection and their cytotoxicity effects on human keratinocyte and lung fibroblast cells [J]10.1039/C7TB02891A ↗
13. Synthesis and characterization of zinc (II)-loaded zeolite/graphene oxide nanocomposite as a new drug carrier [J]10.1016/j.msec.2016.04.090 ↗
14. Toxicity of a polymer-graphene oxide composite against bacterial planktonic cells, biofilms, and mammalian cells [J]10.1039/c2nr30774j ↗
15. In vitro and in vivo comparison of the immunotoxicity of single- and multi-layered graphene oxides with or without pluronic F-127 [J]10.1038/srep38884 ↗
16. Synergistic antibacterial actions of graphene oxide and antibiotics towards bacteria and the toxicological effects of graphene oxide on human epidermal keratinocytes [J]10.1016/j.ejps.2019.105087 ↗
17. Nano-graphene oxide improved the antibacterial property of antisense yycG RNA on staphylococcus aureus [J]10.1186/s13018-019-1356-x ↗
18. Biocompatibility enhancement of graphene oxide-silver nanocomposite by functionalisation with polyvinylpyrrolidone [J]10.1049/iet-nbt.2018.5321 ↗
19. Reduced graphene oxide/TiO2 nanocomposites coating of cotton fabrics with antibacterial and self-cleaning properties [J]10.1177/1528083718779447 ↗
20. Metal-organic-framework-derived 2D carbon nanosheets for localized multiple bacterial eradication and augmented anti-infective therapy [J]10.1021/acs.nanolett.9b01400 ↗
21. Injectable antimicrobial conductive hydrogels for wound disinfection and infectious wound healing [J]10.1021/acs.biomac.9b01732 ↗
22. Functionalized GO nanovehicles with nitric oxide release and photothermal activity-based hydrogels for bacteria-infected wound healing [J]
23. Polyurethane-modified graphene oxide composite bilayer wound dressing with long-lasting antibacterial effect [J]10.1016/j.msec.2020.110833 ↗
24. Development of antibiofilm nanocomposites: Ag/Cu bimetallic nanoparticles synthesized on the surface of graphene oxide nanosheets [J]10.1021/acsami.0c06054 ↗
25. Thin-film nanocomposite reverse osmosis membranes with enhanced antibacterial resistance by incorporating p-aminophenol-modified graphene oxide [J]10.1016/j.seppur.2019.116017 ↗
26. Graphene decorated zinc oxide and curcumin to disinfect the methicillin-resistant staphylococcus aureus [J]10.3390/nano10051004 ↗
27. Facile synthesis of silver@graphene oxide nanocomposites and their enhanced antibacterial properties [J]10.1039/c0jm03376f ↗
28. In vitro and in vivo antimicrobial evaluation of graphene-polyindole (Gr@PIn) nanocomposite against methicillin-resistant staphylococcus aureus pathogen [J]10.1021/acsomega.8b00326 ↗
29. Preparation of graphene oxide with silver nanowires to enhance antibacterial properties and cell compatibility [J]10.1039/C5RA16371D ↗
30. Flexible nanoholey patches for antibiotic-free treatments of skin infections [J]10.1021/acsami.7b12949 ↗
31. Thermoresponsive in situ forming hydrogel with sol-gel irreversibility for effective methicillin-resistant staphylococcus aureus infected wound healing [J]10.1021/acsnano.9b02845 ↗
32. Daptomycin and AgNP co-loaded rGO nanocomposites for specific treatment of Gram-positive bacterial infection in vitro and in vivo [J]10.1039/C9BM01229J ↗
33. Electrospinning of scaffolds from the polycaprolactone/polyurethane composite with graphene oxide for skin tissue engineering [J]10.1007/s12010-019-03192-x ↗
34. Both tough and soft double network hydrogel nanocomposite based on O‐carboxymethyl chitosan/poly (vinyl alcohol) and graphene oxide: a promising alternative for tissue engineering [J]10.1002/pen.25297 ↗
35. Temporary skin grafts based on hybrid graphene oxide-natural biopolymer nanofibers as effective wound healing substitutes: pre-clinical and pathological studies in animal models [J]
36. Li · 2017
37. N-acetyl cysteine-loaded graphene oxide-collagen hybrid membrane for scarless wound healing [J]10.7150/thno.34480 ↗
38. Mussel-inspired electroactive and antioxidative scaffolds with incorporation of polydopamine-reduced graphene oxide for enhancing skin wound healing [J]10.1021/acsami.8b18931 ↗
39. Graphene-based 2D constructs for enhanced fibroblast support [J]10.1371/journal.pone.0232670 ↗
40. Graphene functionalized decellularized scaffold promotes skin cell proliferation [J]10.1002/cjce.23588 ↗
41. Enhanced physical, mechanical, and cytocompatibility behavior of polyelectrolyte complex hydrogels by reinforcing halloysite nanotubes and graphene oxide [J]10.1016/j.compscitech.2019.03.008 ↗
42. The effects of graphene and mesenchymal stem cells in cutaneous wound healing and their putative action mechanism [J]10.2147/IJN.S190928 ↗
43. Three-dimensional graphene foams loaded with bone marrow derived mesenchymal stem cells promote skin wound healing with reduced scarring [J]10.1016/j.msec.2015.07.062 ↗
44. Use of embryonic fibroblasts associated with graphene quantum dots for burn wound healing in Wistar rats [J]10.1007/s11626-019-00331-w ↗
45. Injectable self-healing supramolecular hydrogels with conductivity and photo-thermal antibacterial activity to enhance complete skin regeneration [J]10.1016/j.cej.2020.125994 ↗
46. Yu · 2019
47. Qian · 2019
48. Effect of graphene oxide nanosheets on the physico-mechanical properties of chitosan/bacterial cellulose nanofibrous composites [J]10.1016/j.compositesa.2016.03.011 ↗
49. Polydimethylsiloxane incorporated with reduced graphene oxide (rGO) sheets for wound dressing application: preparation and characterization [J]10.1016/j.colsurfb.2018.03.008 ↗
50. Adhesive hemostatic conducting injectable composite hydrogels with sustained drug release and photothermal antibacterial activity to promote full-thickness skin regeneration during wound healing [J]10.1002/smll.201900046 ↗
51. Graphene oxide-modified electrospun polyvinyl alcohol nanofibrous scaffolds with potential as skin wound dressings [J]10.1039/C7RA03997B ↗
52. Electro-responsive graphene oxide hydrogels for skin bandages: the outcome of gelatin and trypsin immobilization [J]10.1016/j.ijpharm.2018.05.027 ↗
53. Li · 2017
54. In vitro pro-inflammatory effects of graphene and graphene oxide on human skin keratinocytes and monocytes [J]
55. Keratinocytes are capable of selectively sensing low amounts of graphene-based materials:implications for cutaneous applications [J]10.1016/j.carbon.2019.12.064 ↗
56. Pluronic® F127 stabilized reduced graphene oxide hydrogel for the treatment of psoriasis: in vitro and in vivo studies [J]
57. Antioxidant graphene oxide nanoribbon as a novel whitening agent inhibits microphthalmia-associated transcription factor-related melanogenesis mechanism [J]10.1021/acsomega.9b04316 ↗
58. Optical properties of breast tumor phantoms containing carbon nanotubes and nanohorns [J]10.1117/1.3574762 ↗
59. Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites [J]10.1039/C5RA24662H ↗
60. Near-infrared stimulated hydrogel patch for photothermal therapeutics and thermoresponsive drug delivery [J]10.1016/j.jphotobiol.2020.111960 ↗
61. GO/TiO2 hybrid nanoparticles as a new photosensitizer in photodynamic therapy of A375 melanoma cancer cells [J]
62. Photodynamic therapy using graphene quantum dot derivatives [J]10.1016/j.jssc.2019.121107 ↗
63. Ultralow-intensity near infrared light synchronously activated collaborative chemo/photothermal/photodynamic therapy [J]10.1039/C9BM01607D ↗
64. Current methods for skeletal muscle tissue repair and regeneration [J]
65. Stem cell therapies for muscle disorders [J]10.1097/WCO.0b013e328357f288 ↗
66. Cellular and molecular regulation of muscle regeneration [J]10.1152/physrev.00019.2003 ↗
67. Synthetic scaffolds for musculoskeletal tissue engineering: cellular responses to fiber parameters [J]10.1038/s41536-019-0076-5 ↗
68. 3D graphene scaffolds for skeletal muscle regeneration: future perspectives [J]10.3389/fbioe.2020.00383 ↗
69. Hierarchical graphene-based films with dynamic self-siffening for biomimetic artificial muscle [J]10.1002/adfm.201503917 ↗
70. Graphene foam as a three-dimensional platform for myotube growth [J]10.1021/acsbiomaterials.6b00139 ↗
71. Biomimetic antimicrobial cloak by graphene-oxide agar hydrogel [J]10.1038/s41598-017-00063-5 ↗
72. Micropatterned conductive hydrogels as multifunctional muscle-mimicking biomaterials: graphene-incorporated hydrogels directly patterned with femtosecond laser ablation [J]10.1016/j.actbio.2019.07.044 ↗
73. Biomimetic scaffolds for regeneration of volumetric muscle loss in skeletal muscle injuries [J]10.1016/j.actbio.2015.07.038 ↗
74. Graphene oxide increases the viability of C2C12 myoblasts microencapsulated in alginate [J]10.1016/j.ijpharm.2015.07.062 ↗
75. Graphene oxide enhances alginate encapsulated cells viability and functionalty while not affecting the foreign body response [J]10.1080/10717544.2018.1474966 ↗
76. Anti-oxidant activity reinforced reduced graphene oxide/alginate microgels: mesenchymal stem cell encapsulation and regeneration of infarcted hearts [J]10.1016/j.biomaterials.2019.119513 ↗
77. Three-dimensional graphene oxide-coated polyurethane foams beneficial to myogenesis [J]10.1080/09205063.2017.1348738 ↗
78. Nano-graphene oxide/polyurethane nanofibers: mechanically flexible and myogenic stimulating matrix for skeletal tissue engineering [J]10.1177/2041731419900424 ↗
79. Cardiac cell differentiation of muscle satellite cells on aligned composite electrospun polyurethane with reduced graphene oxide [J]10.1007/s10965-019-1936-9 ↗
80. Stimulated myoblast differentiation on graphene oxide-impregnated PLGA-collagen hybrid fibre matrices [J]10.1186/s12951-015-0081-9 ↗
81. Ternary aligned nanofibers of RGD peptide-displaying M13 bacteriophage/PLGA/graphene oxide for facilitated myogenesis [J]10.7150/ntno.22433 ↗
82. Engineering biomimetic materials for skeletal muscle repair and regeneration [J]10.1002/adhm.201801168 ↗
83. Tissue-engineering scaffolds: characteristics and applications in tissue engineering [J]
84. In vitro and in vivo biocompatibility and osteogenesis of graphene-reinforced nanohydroxyapatite polyamide66 ternary biocomposite as orthopedic implant material [J]10.2147/IJN.S105794 ↗
85. Enhanced bone regeneration using an electrospun nanofibrous membrane – a novel approach [J]10.1016/j.jddst.2019.101163 ↗
86. Nanofilm generated non-pharmacological anabolic bone stimulus [J]10.1002/jbm.a.36807 ↗
87. Biodistribution of a high dose of diamond, graphite, and graphene oxide nanoparticles after multiple intraperitoneal injections in rats [J]10.1186/s11671-015-1107-9 ↗
88. Richard · 2015
89. Reinforcing effect of graphene oxide reinforcement on the properties of poly (vinyl alcohol) and carboxymethyl tamarind gum based phase-separated film [J]10.1016/j.jmbbm.2018.02.021 ↗
90. Green reduced graphene oxide toughened semi-IPN monolith hydrogel as dual responsive drug release system: rheological, physicomechanical, and electrical evaluations [J]10.1021/acs.jpcb.8b02919 ↗
91. Reduced graphene-oxide-embedded polymeric nanofiber mats: an “on-demand” photothermally triggered antibiotic release platform [J]10.1021/acsami.8b14784 ↗
92. Electrothermal patches driving the transdermal delivery of insulin [J]10.1039/C9NH00576E ↗
93. Graphene: a versatile platform for nanotheranostics and tissue engineering [J]10.1016/j.pmatsci.2017.08.004 ↗
94. Hairpin-structured probe conjugated nano-graphene oxide for the cellular detection of connective tissue growth factor mRNA [J]10.1016/j.aca.2018.07.016 ↗
95. New opportunities: second harmonic generation of boron-doped graphene quantum dots for stem cells imaging and ultraprecise tracking in wound healing [J]10.1002/adfm.201902235 ↗
96. “Three-in-one” SERS adhesive tape for rapid sampling, release, and detection of wound infectious pathogens [J]10.1021/acsami.9b12823 ↗
97. Green and mild oxidation: an efficient strategy toward water-dispersible graphene [J]10.1021/acsami.6b13703 ↗
98. Investigation on biophysical properties of hydroxyapatite/graphene oxide (HAp/GO) based binary nanocomposite for biomedical applications [J]10.1016/j.matchemphys.2017.07.001 ↗
99. Ultrasonicated graphene oxide enhances bone and skin wound regeneration [J]10.1016/j.msec.2018.09.051 ↗
100. Bioinspired multifunctional biomaterials with hierarchical microstructure for wound dressing [J]10.1016/j.actbio.2019.10.012 ↗