A magnetic patch robot with photothermal-activated multi-modality for targeted anti-postoperative adhesion
Source abstract
Abstract
Abstract Adhesive patches offer an effective approach for wound closure, making them highly suitable for biomedical applications. However, conventional patches often face limitations such as dual-sided adhesion, lack of shape adaptability, and limited maneuverability, which restrict their applications in deeper tissues. In this paper, we develop a magnetic patch robot (PatchBot), for targeted Janus adhesion with tissues. The PatchBot features a unique triple-layer structure, with adhesive, shape-morphing, and anti-adhesive layers, each fulfilling roles to support targeted attachment, enable shape transformation, and prevent unwanted adhesion to surrounding tissues. The Janus adhesion of the PatchBot was extensively demonstrated across a variety of tissues. A localized near-infrared (NIR) laser irradiation was used to induce programmable shape transformations. Magnetic actuation of the PatchBot for targeted adhesion was successfully demonstrated in ex vivo porcine stomach tissue. NIR light-activated shape-morphing and multimodal magnetic actuation significantly enhance its maneuverability and adaptability in confined in vivo environments while ensuring the structural integrity of the adhesive surface during deployment. This proof-of-concept study demonstrates the feasibility of using PatchBot for targeted wound adhesion, showing its potential for minimally invasive, precision therapies in complex in vivo environments.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Intestinal and Peritoneal Adhesions · Minimally Invasive Surgical Techniques · Hernia repair and management
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (49)
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1. Bioadhesive technology platforms10.1021/acs.chemrev.3c00380 ↗
2. Hydrogel adhesion: a supramolecular synergy of chemistry, topology, and mechanics10.1002/adfm.201901693 ↗
3. A conformable and tough janus adhesive patch with limited 1D swelling behavior for internal bioadhesion10.1002/adfm.202303836 ↗
4. Hydrogel bioadhesives harnessing nanoscale phase separation for Achilles tendon repairing10.1007/s12274-023-5918-1 ↗
5. Smart skin-adhesive patches: from design to biomedical applications10.1002/adfm.202213560 ↗
6. In situ sensing physiological properties of biological tissues using wireless miniature soft robots10.1126/sciadv.adg3988 ↗
7. Adhesive hemostatic hydrogel with ultrafast gelation arrests acute upper gastrointestinal hemorrhage in pigs10.1002/adfm.202109332 ↗
8. An adhesive/anti-adhesive Janus tissue patch for efficient closure of bleeding tissue with inhibited postoperative adhesion10.1002/advs.202301427 ↗
9. Modular stimuli-responsive hydrogel sealants for early gastrointestinal leak detection and containment10.1038/s41467-022-34272-y ↗
10. Formulation and pharmacokinetic evaluation of a drug-in-adhesive patch for transdermal delivery of koumine10.1208/s12249-020-01793-y ↗
11. Adhesive hydrogel patch-mediated combination drug therapy induces regenerative wound healing through reconstruction of regenerative microenvironment10.1002/adhm.202203094 ↗
12. An off-the-shelf bioadhesive patch for sutureless repair of gastrointestinal defects10.1126/scitranslmed.abh2857 ↗
13. Hydrogel-functionalized bandages with Janus wettability for efficient unidirectional drug delivery and wound care10.1021/acsnano.3c10766 ↗
14. Bioorthogonal catalytic patch10.1038/s41565-021-00910-7 ↗
15. A strain-programmed patch for the healing of diabetic wounds10.1038/s41551-022-00905-2 ↗
16. Multifunctional smart skin adhesive patches for advanced health care10.1002/adhm.201800275 ↗
17. Dry double-sided tape for adhesion of wet tissues and devices10.1038/s41586-019-1710-5 ↗
18. Hydrogel tapes for fault-tolerant strong wet adhesion10.1038/s41467-021-27529-5 ↗
19. A sandwiched patch toward leakage-free and anti-postoperative tissue adhesion sealing of intestinal injuries10.1016/j.bioactmat.2022.12.003 ↗
20. A tissue adhesion-controllable and biocompatible small-scale hydrogel adhesive robot10.1002/adma.202109325 ↗
21. Hydrogel bioadhesives with extreme acid-tolerance for gastric perforation repairing10.1002/adfm.202202285 ↗
22. Magnetic living hydrogels for intestinal localization, retention, and diagnosis10.1002/adfm.202010918 ↗
23. Microrobots for targeted delivery and therapy in digestive system10.1021/acsnano.2c04716 ↗
24. A magnetic multi-layer soft robot for on-demand targeted adhesion10.1038/s41467-024-44995-9 ↗
25. Clinical translation of wireless soft robotic medical devices10.1038/s44222-024-00156-7 ↗
26. Multimodal soft robotic actuation and locomotion10.1002/adma.202308829 ↗
27. Soft-bodied adaptive multimodal locomotion strategies in fluid-filled confined spaces10.1126/sciadv.abh2022 ↗
28. Wireless soft millirobots for climbing three-dimensional surfaces in confined spaces10.1126/sciadv.abn3431 ↗
29. A multifunctional origami patch for minimally invasive tissue sealing10.1002/adma.202007667 ↗
30. A bioinspired multilegged soft millirobot that functions in both dry and wet conditions10.1038/s41467-018-06491-9 ↗
31. Soft micromachines with programmable motility and morphology10.1038/ncomms12263 ↗
32. A shape-programmable hierarchical fibrous membrane composite system to promote wound healing in diabetic patients10.1002/smll.202107544 ↗
33. Stiffness-tunable velvet worm–inspired soft adhesive robot10.1126/sciadv.adp8260 ↗
34. Magnetically actuated microrobots as a platform for stem cell transplantation10.1126/scirobotics.aav4317 ↗
35. Sperm-hybrid micromotor for targeted drug delivery10.1021/acsnano.7b06398 ↗
36. Structured light enables biomimetic swimming and versatile locomotion of photoresponsive soft microrobots10.1038/nmat4569 ↗
37. Dual-responsive biohybrid neutrobots for active target delivery10.1126/scirobotics.aaz9519 ↗
38. Multifunctional ferrofluid-infused surfaces with reconfigurable multiscale topography10.1038/s41586-018-0250-8 ↗
39. Ultra-extensible ribbon-like magnetic microswarm10.1038/s41467-018-05749-6 ↗
40. Biodegradable untethered magnetic hydrogel milli-grippers10.1002/adfm.202004975 ↗
41. Voxelated three-dimensional miniature magnetic soft machines via multimaterial heterogeneous assembly10.1126/scirobotics.abf0112 ↗
42. Environmentally adaptive shape-morphing microrobots for localized cancer cell treatment10.1021/acsnano.1c06651 ↗
43. Inside-out 3D reversible ion-triggered shape-morphing hydrogels10.34133/2019/6398296 ↗
44. Small-scale soft-bodied robot with multimodal locomotion10.1038/nature25443 ↗
45. Magnetic helical micromachines: fabrication, controlled swimming, and cargo transport10.1002/adma.201103818 ↗
46. Biomimetic natural biopolymer-based wet-tissue adhesive for tough adhesion, seamless sealed, emergency/nonpressing hemostasis, and promoted wound healing10.1002/adfm.202211340 ↗
47. Injectable, self-healing hydrogel adhesives with firm tissue adhesion and on-demand biodegradation for sutureless wound closure10.1126/sciadv.adh4327 ↗
48. A nonswelling hydrogel with regenerable high wet tissue adhesion for bioelectronics10.1002/adma.202212302 ↗
49. Hydrophobic cross-linked chains regulate high wet tissue adhesion hydrogel with toughness, anti-hydration for dynamic tissue repair10.1002/adma.202310164 ↗