journal article·2025-03Open access

Effect of solvent pretreatments on intraradicular bond strength of bioactive cements

Ikram Aqel Salim, Anas Aaqel Salim, Thiago Henrique Scarabello Stape, Mustafa Murat Mutluay, Arzu Tezvergil-Mutluay

Abstract

Bioactive materials are gaining interest in dentistry due to their ability to interact with dental tissues promoting healing and regeneration; albeit their ability to bond to root dentin remains unclear. This study investigated the effect of solvent-containing pretreatments on intraradicular bond strengths of bioactive cements. Sound premolars were decoronated, root canals were instrumented and irrigated using sodium hypochlorite and water. Roots were randomly divided into eighteen groups (n = 7/group) based on dentin pretreatments (no treatment, dimethyl sulfoxide (DMSO), ethanol (EtOH), EtOH/H 2 O, DMSO/H 2 O and DMSO/EtOH) and bioactive cements; a light-curable calcium silicate (Theracal LC, Bisco, Chicago, Illinois, USA), a mineral trioxide aggregate (Orbis MTA, P.L. Superior Dental Materials GmbH, Hamburg, Germany), and an experimental surface pre-reacted glass ionomer root canal material (S-PRG, Shofu Inc, Higashiyama-ku, Kyoto, Japan). Root canals were filled with bioactive cements and stored for 7 days at 37 °C. Filled roots were sectioned perpendicular to their longitudinal axis to obtain 1-mm thick slices. Intraradicular bond strengths were measured by the push-out bond strength test (0.5 mm/min). Analysis of failure mode was performed using a stereomicroscope. Characterization of bonded interfaces was performed via SEM. Bond strength data was analyzed by Kruskal Wallis test and ANOVA on ranks (α = 0.05). Bond strengths varied according to bioactive cements, Theracal > MTA > S-PRG, and root thirds ( p < 0.05). Aqueous (DMSO/H 2 O) or ethanolic (DMSO/EtOH) dilutions of DMSO increased Theracal bond strengths to apical root segments ( p < 0.05). While MTA bond strengths were not affected by pretreatments, undiluted ethanol reduced bond strengths of S-PRG to apical root segments ( p < 0.05). Intraradicular bonding of bioactive cements may vary according to root canal depth and material composition. Solvent-based pretreatments containing DMSO might improve intraradicular bonding of resin-modified bioactive cements in a concentration-dependent manner.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Endodontics and Root Canal Treatments · Dental materials and restorations · Dental Radiography and Imaging

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (56)

Show source-provided references
1. Root end filling materials: a review10.1111/j.1600-9657.1996.tb00510.x ↗
2. Do endodontic compounds induce genetic damage? A comprehensive review10.1016/j.tripleo.2007.07.045 ↗
3. Apical adaptation, sealing ability and push-out bond strength of five root-end filling materials10.1590/1807-3107BOR-2014.vol28.0043 ↗
4. Bioactivity, cytocompatibility and thermal properties of experimental Bioglass-reinforced composites as potential root-canal filling materials10.1016/j.jmbbm.2017.01.022 ↗
5. Innovative root-end filling materials based on calcium-silicates and calcium-phosphates10.1007/s10856-017-5847-1 ↗
6. Torabinejad
7. Sealing ability of mineral trioxide aggregate, calcium phosphate and polymethylmethacrylate bone cements on root ends prepared using an Erbium: yttriumaluminium garnet laser and ultrasonics evaluated by confocal laser scanning microscopy10.4103/0972-0707.114355 ↗
8. Effect of medicaments used in endodontic regeneration technique on push-out bond strength of MTA and Biodentine10.1080/13102818.2015.1109477 ↗
9. Antimicrobial activity of ProRoot MTA in contact with blood10.1038/srep41359 ↗
10. Evaluation of the tissue reaction to fast endodontic cement (CER) and angelus MTA10.1016/j.joen.2009.06.010 ↗
11. Physical and chemical properties of new-generation endodontic materials10.1016/j.joen.2009.11.012 ↗
12. Physical and chemical properties of a new root-end filling material10.1016/S0099-2399(06)80967-2 ↗
13. Biocompatibility and sealing ability of mineral trioxide aggregate and biodentine as root-end filling material: a systematic review
14. Chemical-physical properties of TheraCal, a novel light-curable MTA-like material for pulp capping10.1111/j.1365-2591.2012.02013.x ↗
15. A confocal laser scanning microscopic study evaluating the sealing ability of mineral trioxide aggregate, biodentine and anew pulp capping agent-theracal10.1055/s-0038-1672009 ↗
16. Polymerizable dental pulp healing, capping, and lining material and method for use
17. A review of chemical-approach and ultramorphological studies on the development of fluoride-releasing dental adhesives comprising new pre-reacted glass ionomer (PRG) fillers10.4012/dmj.27.315 ↗
18. Antibacterial activity of composite resin with glass-ionomer filler particles10.4012/dmj.2009-050 ↗
19. Evaluation of the ion-releasing and recharging abilities of a resin-based fissure sealant containing S-PRG filler10.4012/dmj.2011-124 ↗
20. Effect of ammonium hexafluorosilicate application for arresting caries treatment on demineralized primary tooth enamel10.2334/josnusd.55.115 ↗
21. Detection of ions released from S-PRG fillers and their modulation effect10.4012/dmj.2010-015 ↗
22. Effects of surface pre-reacted glass-ionomer fillers on mineral induction by phosphoprotein10.1016/j.jdent.2010.10.011 ↗
23. Effects of immersion in solution of an experimental toothpaste containing S-PRG filler on like-remineralizing ability of etched enamel10.4012/dmj.2013-224 ↗
24. A novel dry-bonding approach to reduce collagen degradation and optimize resin-dentin interfaces10.1038/s41598-018-34726-8 ↗
25. Optimization of the etch-and-rinse technique: new perspectives to improve resin–dentin bonding and hybrid layer integrity by reducing residual water using dimethyl sulfoxide pretreatments10.1016/j.dental.2018.03.010 ↗
26. Effect of various dimethyl sulfoxide concentrations on the durability of dentin bonding and hybrid layer quality10.4012/dmj.2017-213 ↗
27. Influence of dimethyl sulfoxide used as a solvent on the physical properties and long-term dentin bonding of hydrophilic resins10.1016/j.jmbbm.2016.07.003 ↗
28. Dentin bond optimization using the dimethyl sulfoxide-wet bonding strategy: a 2-year in vitro study10.1016/j.dental.2016.09.015 ↗
29. Effect of dimethyl sulfoxide wet-bonding technique on hybrid layer quality and dentin bond strength10.1016/j.dental.2015.03.008 ↗
30. Effect of ethanol application on post-luting to intraradicular dentine10.1111/j.1365-2591.2008.01491.x ↗
31. Concentration effect of DMSO-dry bonding on the stability of etch-and-rinse bonds10.1016/j.dental.2023.09.013 ↗
32. The effect of dimethyl sulfoxide (DMSO) on dentin bonding and nanoleakage of etch-and-rinse adhesives10.1016/j.dental.2013.07.014 ↗
33. Dentin permeability: the basis for understanding pulp reactions and adhesive technology10.1590/S0103-64402009000100001 ↗
34. Dry bonding to dentin: broadening the moisture spectrum and increasing wettability of etch-and-rinse adhesives10.1016/j.dental.2021.08.021 ↗
35. The effect of smear layer on the push-out bond strength of root canal calcium silicate cements10.1016/j.dental.2013.04.020 ↗
36. Evaluation of selected properties of a new root repair cement containing surface pre-reacted glass ionomer fillers10.1007/s00784-016-1715-5 ↗
37. An in vitro comparison of the intraradicular dentin bond strength of resilon and gutta-percha10.1016/j.joen.2006.03.020 ↗
38. The adhesion between fibre posts and root canal walls: comparison between microtensile and push-out bond strength measurements10.1111/j.1600-0722.2004.00146.x ↗
39. The influence of methodological variables on the push-out resistance to dislodgement of root filling materials: a meta-regression analysis10.1111/iej.12539 ↗
40. Physical-mechanical properties of a resin-modified calcium silicate material for pulp capping10.1590/0103-6440202003079 ↗
41. The biomineralization ability of mineral trioxide aggregate and portland cement on dentin enhances the push-out strength10.1016/j.joen.2009.10.009 ↗
42. Push-out strength of modified Portland cements and resins
43. Dentin bond strength of calcium silicate-based materials: a systematic review of in vitro studies
44. Evaluation of the ions release/incorporation of the prototype S-PRG fller-containing endodontic sealer10.4012/dmj.2011-101 ↗
45. Performance of two blue light-emitting-diode dental light curing units with distance and irradiation-time10.1016/S0109-5641(03)00070-8 ↗
46. Bonding to root canal: structural characteristics of the substrate
47. Density of dentinal tubules affects the tensile strength of root dentin10.1016/S0109-5641(03)00106-4 ↗
48. Tubular sclerosis rather than the smear layer impedes dye penetration into the dentine of endodontically instrumented root canals10.1111/j.1365-2591.2005.01042.x ↗
49. Biomineralization ability and interaction of mineral trioxide aggregate and white portland cement with dentin in a phosphate-containing fluid10.1016/j.joen.2009.02.011 ↗
50. Dislodgement resistance of calcium silicate-based materials from root canals with varying thickness of dentine10.1111/iej.12573 ↗
51. MTA - an hydraulic silicate cement: review update and setting reaction10.1016/j.dental.2011.02.001 ↗
52. The pursuit of resin-dentin bond durability: simultaneous enhancement of collagen structure and polymer network formation in hybrid layers10.1016/j.dental.2021.03.010 ↗
53. Role of dimethyl sulfoxide as a solvent for vinyl polymerization10.1002/pol.1970.150080614 ↗
54. Limitations in bonding to dentin and experimental strategies to prevent bond degradation10.1177/0022034510391799 ↗
55. Mineral trioxide aggregate: present and future developments10.1111/etp.12073 ↗
56. Calcium silicate-based cements: composition, properties, and clinical applications10.1111/jicd.12195 ↗