Use of the adhesive layer as a controlled release platform for doxycycline, as promising advancement for longer durability of dentin adhesion
Source abstract
Abstract
Abstract The loss of dentin adhesive efficiency can put at risk the durability of dental restorations. This loss of stability is a result of the combination of hydrolysis and the activity of metalloproteinases. The use of enzyme inhibitors can obtain higher adhesive stabilities. In this sense, the present paper aimed to evaluate the efficiency of doxycycline releasing adhesive systems using clay particles as a release modulator. The adhesive systems were based on BisGMA, UDMA, HEMA, and TEGDMA, including camphorquinone (photoinitiator) and ethanol (solvent). Different amounts of doxycycline (1–4%) were added to these systems in the presence or absence of 0.2% clay. The systems were evaluated by X-ray diffraction, infrared spectroscopy, flexural strength (and elastic modulus), doxycycline release, dentin MMP-2 inhibition capacity, and dentin adhesion. The results indicated that the addition of clays reinforces the adhesive systems mechanically, generating greater adhesive strengths. These nanoparticles also contribute to obtaining more controlled release profiles allowing a longer effective period of MMP-2 inhibition. The use of 1 and 2% of doxycycline, when combined with the clays, was able to elevate the adhesive stability after 18 months, indicating that clays in these systems represent a highly promising alternative to increasing the stability of dentin adhesion.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Dental materials and restorations · Endodontics and Root Canal Treatments · Dental Erosion and Treatment
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (52)
Show source-provided references
1. Influence of acid etching and universal adhesives on the bond strength to dentin10.1590/0103-6440202002884 ↗
2. Santiagoe SL effect of metalloproteinase inhibitors on bond strength of a self-etching adhesive on erosively demineralized dentin
3. Influence of dentin biomodification with epigallocatechin-3-gallate on the bond strength of self-etch adhesive: twelve-month results10.1016/j.ijadhadh.2016.08.007 ↗
4. Inhibition of matrix metalloproteinases: a troubleshooting for dentin adhesion10.5395/rde.2020.45.e31 ↗
5. Mechanical stability of resin–dentin bond components10.1016/j.dental.2004.06.001 ↗
6. Bond stability of conventional adhesive system with MMP inhibitors to superficial and deep dentin10.1016/j.jmbbm.2019.103402 ↗
7. Parsaie · 2019 · 866129
8. Biodegradation of resin–dentin interfaces is dependent on the restorative material, mode of adhesion, esterase or MMP inhibition10.1016/j.dental.2018.05.008 ↗
9. Effectiveness of pre-treatment with chlorhexidine in restoration retention: a 36-month follow-up randomized clinical trial10.1016/j.jdent.2017.02.014 ↗
10. Five-year effects of chlorhexidine on the in vitro durability of resin/dentin interfaces
11. Long-term bond strength and endogenous enzymatic activity of a chlorhexidine-containing commercially available adhesive10.1016/j.jdent.2019.03.004 ↗
12. Doxycycline-encapsulated nanotube-modified dentin adhesives10.1177/0022034514549997 ↗
13. Chlorhexidine-modified nanotubes and their effects on the polymerization and bonding performance of a dental adhesive10.1016/j.dental.2020.03.007 ↗
14. Correction to: the use of clays for chlorhexidine controlled release as a new perspective for longer durability of dentin adhesion10.1007/s10856-019-6344-5 ↗
15. Doxycycline as a dentin pretreatment agent for MMP-2 inhibition and maintaining hybrid layer stability over time10.1016/j.ijadhadh.2019.102510 ↗
16. Effect of organo-smectite clays on the mechanical properties and thermal stability of EVA nanocomposites10.1016/j.clay.2020.105750 ↗
17. The use of montmorillonite clays as reinforcing fillers for dental adhesives10.1590/1980-5373-MR-2015-0375 ↗
18. Poly(acrylic acid) grafted montmorillonite as novel fillers for dental adhesives: synthesis, characterization and properties of the adhesive10.1016/j.dental.2011.11.010 ↗
19. Impact of solvent evaporation and curing protocol on degree of conversion of etch-and-rinse and multimode adhesives systems10.1155/2019/5496784 ↗
20. Resins-based denture soft lining materials modified by chlorhexidine salt incorporation: an in vitro analysis of antifungal activity, drug release and hardness10.1016/j.dental.2014.05.004 ↗
21. Adhesive performance of a multi-mode adhesive system: 1-Year in vitro study10.1016/j.jdent.2013.12.008 ↗
22. Carbodiimide inactivation of MMPs and effect on dentin bonding10.1177/0022034513516465 ↗
23. Chlorhexidine stabilizes the adhesive interface: a 2-year in vitro study10.1016/j.dental.2009.11.153 ↗
24. Fabrication of doxycycline-loaded electrospun PCL/PEO membranes for a potential drug delivery system10.1016/j.ijpharm.2019.04.073 ↗
25. Physiochemical characterization and release rate studies of solid dispersions of ketoconazole with Pluronic F127 and PVP K-30
26. Obtaining and characterizing dental hybrid composites with clay or silica nanoparticles and boron-aluminum-silicate glass microparticles10.1590/0104-1428.01416 ↗
27. New silyl-functionalized BisGMA provides autonomous strengthening without leaching for dental adhesives10.1016/j.actbio.2018.10.033 ↗
28. The effect of light intensity on double bond conversion and flexural strength of a model, unfilled dental resin10.1016/S0109-5641(02)00090-8 ↗
29. Short-term and long-term release of monomers from newly developed resin-modified ceramics and composite resin CAD-CAM blocks10.1016/j.prosdent.2019.01.012 ↗
30. Degree of conversion and polymerization shrinkage of low shrinkage bulk fill resin composites
31. Effect of monomer type on the C C degree of conversion, water sorption and solubility, and color stability of model dental composites10.1016/j.dental.2017.01.010 ↗
32. Rechargeable anti-microbial adhesive formulation containing cetylpyridinium chloride montmorillonite10.1016/j.actbio.2019.09.045 ↗
33. Effect of adding Matrix Metallo proteinase inhibitors on the degree of conversion of monomers to polymer an experimental bonding agent
34. Controlled release of chlorhexidine diacetate from a Porous methacrylate system: supercritical fluid assisted foaming and impregnation10.1002/jps.20850 ↗
35. Chlorhexidine release and water sorption characteristics of chlorhexidine-incorporated hydrophobic/hydrophilic resins10.1016/j.dental.2008.03.011 ↗
36. Synthesis of novel chlorhexidine spheres with controlled release from a UDMA–HEMA resin using ultrasound10.1016/j.dental.2017.04.003 ↗
37. Influence of chlorhexidine on the degree of conversion and E-modulus of experimental adhesive blends10.1016/j.dental.2009.05.008 ↗
38. Physical and mechanical properties of linear low-density polyethylene/cycloolefin copolymer/layered silicate nanocomposite10.1002/pc.23514 ↗
39. Formulation of drug-Cyclodextrin10.1007/978-3-662-45013-0_14 ↗
40. Chlorhexidine release and water sorption characteristics of chlorhexidine-incorporated hydrophobic/hydrophilic resins10.1016/j.dental.2008.03.011 ↗
41. Smectite as ciprofloxacin delivery system: intercalation and temperature-controlled release properties10.1016/j.clay.2016.02.006 ↗
42. Gallic acid-loaded montmorillonite nanostructure as a new controlled release system10.1016/j.clay.2015.10.020 ↗
43. Drug release characteristics from nanoclay hybrids and their dispersions in organic polymers10.1016/j.ijpharm.2011.05.028 ↗
44. Ianchis · 2020 · vol. 27 · 919
45. Synthesis and characterization of a Chitosan/PVA antimicrobial hydrogel nanocomposite for responsive wound management materials10.4172/1948-5948.1000264 ↗
46. Doxycycline as a dentin pretreatment agent for MMP-2 inhibition and maintaining hybrid layer stability over time10.1016/j.ijadhadh.2019.102510 ↗
47. Doxycycline-loaded nanotube-modified adhesives inhibit MMP in a dose-dependent fashion10.1007/s00784-017-2215-y ↗
48. A novel dentin bonding system containing poly(methacrylic acid) grafted nanoclay: synthesis, characterization and properties10.1016/j.dental.2012.06.004 ↗
49. Multifunctional monomer acts as co-initiator and crosslinker to provide autonomous strengthening with enhanced hydrolytic stability in dental adhesives10.1016/j.dental.2019.11.007 ↗
50. Multifunctional monomer acts as co-initiator and crosslinker to provide autonomous strengthening with enhanced hydrolytic stability in dental adhesives10.1016/j.dental.2019.11.007 ↗
51. Effects of storage media on mechanical properties of adhesive systems
52. PLGA nanoparticles as chlorhexidine-delivery carrier to resin-dentin adhesive interface10.1016/j.dental.2017.04.015 ↗