journal article·2023-07

Bonding of thermoplastic microfluidic device by water assistance

Chia-Wen Tsao, Chang-Yen Chang, Wei-Wen Hu, Yun-Shan Tian

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Abstract

We present a water-assisted microwave bonding (H 2 O-μWave bonding) process for sealing thermoplastic microfluidic devices. We use water as the bonding reagent to assist the formation of covalent bonds after surface activation and water evaporation procedures. In surface activation step, we exam UV/Ozone and O 2 plasma surface treatments and their effects of the surface wettability, optical transmissivity, surface morphology, and surface chemistry on a polymethyl methacrylate (PMMA) substrate in H 2 O-μWave bonding. After surface activation, water evaporation step was performed to form the bonds. The bonding can be simply formed by leaving the surface-activated pair in the room environment after water application. We examined the bonding strength and coverage of PMMA by both room temperature drying and microwave annealing approaches in H 2O-μWave bonding. Finally, stability and multilayer bonding were also tested to evaluate the quality of H 2O-μWave bonding.
Source: expertdata · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Microfluidic and Capillary Electrophoresis Applications · Nanofabrication and Lithography Techniques · Innovative Microfluidic and Catalytic Techniques Innovation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (38)

Show source-provided references
1. 30 years of microfluidics10.1016/j.mne.2019.01.003 ↗
2. The origins and the future of microfluidics10.1038/nature05058 ↗
3. Organ/body-on-a-chip based on microfluidic technology for drug discovery10.1016/j.dmpk.2017.11.003 ↗
4. Advances in organ-on-a-chip engineering10.1038/s41578-018-0034-7 ↗
5. Towards practical sample preparation in point-of-care testing: user-friendly microfluidic devices10.1039/D0LC00047G ↗
6. Microfluidics and point-of-care testing10.1039/b817915h ↗
7. Microfluidic-based approaches for COVID-19 diagnosis10.1063/5.0031406 ↗
8. A high-throughput multiplexed microfluidic device for COVID-19 serology assays10.1039/D0LC01068E ↗
9. Polymer microfluidic devices10.1016/S0039-9140(01)00594-X ↗
10. Interplay between materials and microfluidics
11. Materials for microfluidic immunoassays: a review10.1002/adhm.201601403 ↗
12. Polymer microfluidics: simple, low-cost fabrication process bridging academic lab research to commercialized production10.3390/mi7120225 ↗
13. Polymer microfabrication technologies for microfluidic systems10.1007/s00216-007-1692-2 ↗
14. Recent advances in thermoplastic microfluidic bonding10.3390/mi13030486 ↗
15. Micromilling: a method for ultra-rapid prototyping of plastic microfluidic devices10.1039/C5LC00234F ↗
16. Inexpensive, rapid prototyping of microfluidic devices using overhead transparencies and a laser print, cut and laminate fabrication method10.1038/nprot.2015.051 ↗
17. 3D printing of inertial microfluidic devices10.1038/s41598-020-62569-9 ↗
18. Micro hot embossing of thermoplastic polymers: a review
19. Rapid polymer microchannel fabrication by hot roller embossing process10.1007/s00542-012-1513-1 ↗
20. Fundamentals of rapid injection molding for microfluidic cell-based assays10.1039/C7LC01052D ↗
21. Bonding of thermoplastic polymer microfluidics10.1007/s10404-008-0361-x ↗
22. Bonding of thermoplastic microfluidics by using dry adhesive tape10.1039/D0RA05876A ↗
23. The identification and screening of lower toxicity solvents for contact adhesives10.1016/j.ijadhadh.2017.06.022 ↗
24. Fabrication of a microfluidic system for capillary electrophoresis using a two-stage embossing technique and solvent welding on poly(methyl methacrylate) with water as a sacrificial layer10.1021/ac7021647 ↗
25. Thermal bonding of polymeric capillary electrophoresis microdevices in water10.1021/ac0262964 ↗
26. A method of water pretreatment to improve the thermal bonding rate of PMMA microfluidic chip10.1007/s00542-012-1466-4 ↗
27. Bonding PMMA microfluidics using commercial microwave ovens10.1088/0960-1317/25/8/085008 ↗
28. Microwave bonding of poly(methylmethacrylate) microfluidic devices using a conductive polymer10.1016/j.jpcs.2011.02.005 ↗
29. A microfluidic chip microwave bonding method based on the PMMA10.4028/www.scientific.net/KEM.562-565.561 ↗
30. Microwave-induced, thermally assisted solvent bonding for low-cost PMMA microfluidic devices10.1088/0960-1317/20/1/015026 ↗
31. Dielectric parameters relevant to microwave dielectric heating10.1039/a827213z ↗
32. The regulation of osteogenesis using electroactive polypyrrole films10.3390/polym8070258 ↗
33. Mechanical and chemical analysis of plasma and ultraviolet–ozone surface treatments for thermal bonding of polymeric microfluidic devices10.1039/B700442G ↗
34. Wavelength sensitivity of the photodegradation of poly (methyl methacrylate)10.1002/app.1993.070470609 ↗
35. Photochemical stability and photostabilizing efficiency of poly (methyl methacrylate) based on 2-(6-methoxynaphthalen-2-yl) propanoate metal ion complexes10.3390/polym7061005 ↗
36. Wettability interpretation of oxygen plasma modified poly (methyl methacrylate)10.1021/la048947s ↗
37. Plasma modification of polymer surfaces for adhesion improvement10.1147/rd.384.0423 ↗
38. The influence of UV-irradiation and support type on surface properties of poly (methyl methacrylate) thin films10.1016/j.apsusc.2005.10.037 ↗