The effect of vitamin C in the formulation of pectin/thiolated alginate buccal adhesive patches: In vitro and Ex vivo evaluation
Source abstract
Abstract
The present study outlines the prospect of a pectin (Pec)/modified alginate (Alg) buccal patch as drug delivery device in the localized treatment of oral cavity diseases. Firstly, Alg was modified with acrylic acid, and thiolated with cystein to enhance its mucoadhesive properties. Then modified Alg was characterized with Fourier transform infrared (FTIR) and proton nuclear magnetic resonance (1HNMR) spectroscopy. As a proof of concept, Pec/modified Alg buccal patches were formed via the conventional solvent casting technique. Then the patches were characterized by FTIR and differential scanning calorimetry/thermal gravimetric analysis (DSC/TGA). Vitamin C (Vit C) was used for in vitro drug release assay, and the release amount was 2.10 mg/g polymer in simulated salivary pH 6.8. Ex vivo mucoadhesion assays of Vit C loaded Pec/modified Alg patch did not have a negative effect on the mucoadhesion feature of the material. The cytotoxicity study indicated that Pec/modified Alg buccal patches did not exhibit apparent cytotoxicity against NIH/3T3 cell lines. Notably, it was found that Vit C in the patch formulation has an accelerating effect on wound healing. According to all results, Vit C loaded Pec/modified Alg buccal patch might be a promising candidate for localized buccal drug release systems.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Wound Healing and Treatments · Advanced Drug Delivery Systems · Corneal Surgery and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (62)
Show source-provided references
1. Role of physicochemical properties of some grades of hydroxypropyl methylcellulose on in vitro mucoadhesion10.1016/j.ijpharm.2021.121218 ↗
2. Comprehensive mucoadhesive study of anionic polymers and their derivate10.1016/j.eurpolymj.2017.06.012 ↗
3. Thiolated pectins: in vitro and ex vivo evaluation of three generations of thiomers10.1016/j.actbio.2021.08.016 ↗
4. Preparation and characterization of mucoadhesive gels containing pentoxifylline loaded nanoparticles for vaginal delivery of genital ulcer10.1007/s13726-021-00913-0 ↗
5. Mucoadhesive hydrogels for buccal drug delivery: in vitro-in vivo correlation study10.1016/j.ejpb.2019.07.019 ↗
6. A gellan gum derivative as in-situ gelling cationic polymer for nasal drug delivery10.1016/j.ijbiomac.2020.04.114 ↗
7. Thiolated cyclodextrins: mucoadhesive and permeation enhancing excipients for ocular drug delivery10.1016/j.ijpharm.2021.120451 ↗
8. Bacterial cellulose adhesive composites for oral cavity applications10.1016/j.carbpol.2021.118403 ↗
9. A critical review about methodologies for the analysis of mucoadhesive properties of drug delivery systems10.1080/03639045.2017.1294600 ↗
10. Development of mucoadhesive modified kappa-carrageenan/pectin patches for controlled delivery of drug in the buccal cavity10.1002/jbm.b.34958 ↗
11. Evaluation of modified pectin/alginate buccal patches with enhanced mucoadhesive properties for drug release systems: in-vitro and ex-vivo study
12. Formulation and in vitro evaluation of xanthan gum-based bilayered mucoadhesive buccal patches of zolmitriptan10.1016/j.carbpol.2013.10.072 ↗
13. Chitosan based sustained release mucoadhesive buccal patches containing verapamil HCl
14. Formulation and evaluation of buccal patches of terbutaline sulphate
15. Characterization of ionic cross-linked composite foams with different blend ratios of alginate/pectin on the synergistic effects for wound dressing application10.1016/j.ijbiomac.2019.11.206 ↗
16. Pectin-chitosan physical hydrogel as potential drug delivery vehicles10.1016/j.ijbiomac.2017.03.167 ↗
17. Mucoadhesion of pectin as evidence by wettability and chain interpenetration10.1016/j.carbpol.2008.03.022 ↗
18. Mucoadhesive properties of various pectins on gastrointestinal mucosa: an in vitro evaluation using texture analyzer10.1016/j.ejpb.2007.01.010 ↗
19. Mucoadhesive polymers and their mode of action: a recent update
20. Mucoadhesive alginate pastes with embedded liposomes for local oral drug delivery10.1016/j.ijbiomac.2017.12.137 ↗
21. Cationic dye removal using novel magnetic/activated charcoal/β-cyclodextrin/alginate polymer nanocomposite10.3390/nano10010170 ↗
22. Synthesis and characterization of pH- and temperature-sensitive materials based on alginate and poly(N-isopropylacrylamide/acrylic acid) for drug delivery10.1007/s00289-015-1550-x ↗
23. Formulation and optimization of sodium alginate polymer film as a buccal mucoadhesive drug delivery system containing cetirizine dihydrochloride10.3390/pharmaceutics13050619 ↗
24. Development of mucoadhesive microbeads using thiolated sodium alginate for intrapocket delivery of resveratrol10.1016/j.ijpharm.2015.04.010 ↗
25. Thiolated sodium alginate conjugates for mucoadhesive and controlled release behavior of metformin microspheres10.1016/j.ijbiomac.2020.08.116 ↗
26. Encapsulation and controlled release of vitamin C in modified cellulose nanocrystal/chitosan nanocapsules10.1016/j.crfs.2021.03.010 ↗
27. Effect of gelatin content and oral processing ability on vitamin C release in gummy jelly10.1007/s13197-021-05061-0 ↗
28. Role of vitamin C in wound healing after dental implant surgery in patient treated with bone grafts and patients with chronic periodontitis10.1111/cid.12647 ↗
29. Polysaccharide-based film loaded with vitamin C and propolis: a promising device to accelerate diabetic wound healing10.1016/j.ijpharm.2018.10.009 ↗
30. Enhancement of Pb(II) adsorption and antibacterial performances of sodium alginate/acrylic acid composite hydrogels via snowflake-like ZnO modification
31. Evaluation of hyaluronic acid nanoparticle embedded chitosan-gelatin hydrogels for antibiotics release10.1002/ddr.21747 ↗
32. Sponge-like chitosan-based nanostructured antibacterial material as a topical hemostat10.1002/app.47522 ↗
33. Characterization and antibacterial activity of gelatin-gellan gum bilayer wound dressing
34. Evaluation of hyaluronic acid nanoparticle embedded chitosan-gelatin hydrogels for antibiotics release10.1002/ddr.21747 ↗
35. A novel wound dressing material: pullulan grafted copolymer hydrogel via UV copolymerization and crosslinking
36. Chitosan/collagen composite films as wound dressings encapsulating allantoin and lidocaine hydrochloride10.1080/00914037.2020.1740993 ↗
37. İpek fibroin/polivinil alkol esaslı ilaç taşıyıcı yara örtüleri
38. Photocurable silk fibroin-based tissue sealants with enhanced adhesive property for the treatment of corneal perforations10.1039/D1TB02502C ↗
39. Dielectric, thermal, and swelling properties of calcium ion-crosslinked sodium alginate film10.1002/pen.23678 ↗
40. Synthesis, characterization and bending behavior of electroresponsive sodium alginate/poly(acrylic acid) interpenetrating network films under an electric field stimulus10.1016/j.snb.2014.06.051 ↗
41. Self-aggregation behavior of hydrophobic sodium alginate derivatives in aqueous solution and their application in the nanoencapsulation of acetamiprid10.1016/j.ijbiomac.2017.08.038 ↗
42. Photopolymerisation and characterization of maleylatedcellulose-g-poly(acrylic acid) superabsorbent polymer10.1016/j.carbpol.2013.09.054 ↗
43. Inulin and poly(acrylic acid) grafted inulin for dissolution enhancement and preliminary controlled release of poorly water-soluble Irbesartan drug10.1016/j.ijpharm.2011.03.029 ↗
44. Preparation, characterization, and in vitro drug release behavior of thiolated alginate nanoparticles loaded budesonide as a potential drug delivery system toward inflammatory bowel diseases10.1080/09205063.2020.1803034 ↗
45. Development of pH sensitive polyacrylamide grafted pectin hydrogel for controlled drug delivery system10.1007/s10856-007-3162-y ↗
46. Development and characterization of pectin/gelatin hydrogel membranes for wound dressing10.1007/s12588-011-9016-y ↗
47. Design of pectin-sodium alginate based films for potential healthcare application: study of chemico-physical interactions between the components of films and assessment of their antimicrobial activity10.1016/j.carbpol.2016.10.054 ↗
48. Safely dissolvable and healable active packaging films based on alginate and pectin10.3390/polym11101594 ↗
49. Drug–polymer interaction between glucosamine sulfate and alginate nanoparticles: FTIR, DSC and dielectric spectroscopy studies10.1088/2043-6262/7/2/025014 ↗
50. Modified cellulose nanocrystal for vitamin C delivery10.1208/s12249-014-0218-4 ↗
51. Facile mechanochemical approach to synthesizing edible food preservation coatings based on alginate/ascorbic acid-layered double hydroxide bio-nanohybrids10.1021/acs.jafc.0c01879 ↗
52. Alginate/pectin aerogel microspheres for controlled release of proanthocyanidins10.1016/j.ijbiomac.2019.06.138 ↗
53. A composite hydrogels of chitosan/heparin/poly(γ-glutamic acid) loaded with superoxide dismutase for wound healing10.1016/j.carbpol.2017.10.036 ↗
54. Development of chitosan/poly(vinly alcohol)/graphene oxide loaded with vanadium doped titanium dioxide patch for visible light driven antibacterial activity and accelerated wound healing application10.1016/j.ijbiomac.2021.10.207 ↗
55. Drug release, cell adhesion and wound healing evaluations of electrospun carboxymethyl chitosan/polyethylene oxide nanofibers containing phenytoin sodium and vitamin C10.1049/iet-nbt.2014.0030 ↗
56. Immune modulatory and antioxidant effects of locally administrated vitamin C in experimental periodontitis in rats10.1080/00016357.2020.1734656 ↗
57. Mucoadhesive gellan gum hydrogel containing diphenyl diselenide-loaded nanocapsules presents improved anti-candida action in a mouse model of vulvovaginal candidiasis10.1016/j.ejps.2021.106011 ↗
58. Wound repair and regeneration: mechanisms, signaling, and translation10.1126/scitranslmed.3009337 ↗
59. In vitro and in vivo assessments of a 3-(3, 4-dihydroxyphenyl)-2-propenoic acid bioconjugated gelatin-based injectable hydrogel for biomedical applications10.1039/C4TB01196A ↗
60. Titanium nanorods loaded PCL meshes with enhanced blood vessel formation and cell migration for wound dressing applications10.1002/mabi.201900058 ↗
61. The effect of thiol functional groups on bovine serum albumin/chitosan buccal mucoadhesive patches
62. Cellular response to vitamin C-enriched chitosan/agarose film with potential application as artificial skin substitute for chronic wound treatment10.3390/cells9051185 ↗