Mushrooms to brushes: Tackling the PEG dilemma in mRNA lipid nanoparticles with complex polymers
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: RNA Interference and Gene Delivery · Nanoparticle-Based Drug Delivery · Nanopore and Nanochannel Transport Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (10)
Show source-provided references
1. Effect of pegylation on pharmaceuticals10.1038/nrd1033 ↗
2. Current landscape of mRNA technologies and delivery systems for new modality therapeutics10.1186/s12929-024-01080-z ↗
3. PEGylated therapeutics in the clinic10.1002/btm2.10600 ↗
4. Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals10.1016/j.addr.2020.07.024 ↗
5. Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products10.1016/j.jconrel.2022.09.031 ↗
6. Implications of Anaphylaxis Following mRNA-LNP Vaccines: It Is Urgent to Eliminate PEG and Find Alternatives10.3390/pharmaceutics17060798 ↗
7. Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine10.1021/acsnano.2c04543 ↗
8. Antibodies against Poly(ethylene glycol) Activate Innate Immune Cells and Induce Hypersensitivity Reactions to PEGylated Nanomedicines10.1021/acsnano.2c12193 ↗
9. Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine10.1021/acsnano.2c04543 ↗
10. High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics