Direct Design of Pharmaceutical Antisolvent Crystallization through Concentration Control
Source abstract
Abstract
Recent advances in in situ measurement technology and automation of batch crystallizers have enabled the development of batch crystallization recipes in which the desired supersaturation profile is followed by feedback control. This paper describes a new approach for following supersaturation setpoints for antisolvent crystallizations that is easy to implement for the tried crystallization. Simulations and application to a proprietary drug compound demonstrate how this combination of automation and in process measurements enables the rapid development of batch crystallization processes in the pharmaceutical industry.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Crystallization and Solubility Studies · Analytical Chemistry and Chromatography · Chemical and Physical Properties in Aqueous Solutions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Merck & Co., Inc., 126 East Lincoln Ave., P.O. Box 2000, Rahway, New Jersey 07065, Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana−Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, and Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576
References (30)
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