A Survey of Cocrystals Reported Prior to 2000

A history of cocrystals reported in the literature prior to the year 2000 is presented. Concentration is on cocrystals that contain only organic components, not including species commonly referred to as solvates and clathrates. However, brief mention is made of some cocrystals containing both organic and inorganic components. The discovery and early history of cocrystals are discussed, with emphasis on centers of activity. Numerous examples are then utilized to illustrate the structural variety and utility of cocrystals described in the literature.