journal article·2025-06Open access

Mechanisms of laminar flow controlled in vitro corrosion of a biodegradable Fe-Mn-C steel

Martin Otto, Thomas Hultsch, Viktoriia Shtefan, Volker Hoffmann, Sviatlana V. Lamaka, Thomas Gemming, Annett Gebert, Jochen Fröhlich, Mikhail L. Zheludkevich, Julia Hufenbach

Corrosion Science· Volume 249

Abstract

The in vitro corrosion of Fe-30Mn-1C in a Ca-modified Hanks’ balanced salt solution was investigated for biodegradable cardiovascular stents with a rotating disc electrode. A blood flow-related approach was developed to adjust laminar flow conditions. Electrochemical monitoring revealed that intermediate flow caused maximum corrosion, while static and high flow conditions led to minimal corrosion. Surface analysis indicated the formation of a non-crystalline, nanoscopic degradation layer, whereby thickness, porosity and layer-disrupting defects are strongly affected by flow conditions. The interplay between laminar flow and the degradation layer was crucial for the steel degradation and discussed by employing a hydrodynamics-based corrosion scheme. • Study of laminar flow conditions with a rotating disc electrode setup • Hydrodynamic characteristics of blood flow-related wall shear stress are established • Rapid corrosion of Fe-Mn-C in Ca-modified Hank’s BSS at intermediate flow (550 RPM) • Mass transfer through a porous layer is inhibiting corrosion at high rotation rate • Evidence of mass transfer instead of wall shear stress effect due to laminar flow
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Corrosion Behavior and Inhibition · Magnesium Alloys: Properties and Applications · Hydrogen embrittlement and corrosion behaviors in metals

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (81)

Show source-provided references
1. New insights and perspectives into biodegradable metals in cardiovascular stents: a mini review10.1016/j.jallcom.2024.175313 ↗
2. Safety and performance of the third-generation drug-eluting resorbable coronary magnesium scaffold system in the treatment of subjects with de novo coronary artery lesions: 6-month results of the prospective, multicenter BIOMAG-I first-in-human study10.1016/j.eclinm.2023.101940 ↗
3. First-in-human evaluation of a novel ultrathin sirolimus-eluting iron bioresorbable scaffold: 3-year outcomes of the IBS-FIM trial
4. Twinning-induced plasticity (TWIP) steels10.1016/j.actamat.2017.06.046 ↗
5. Addressing the slow corrosion rate of biodegradable Fe-Mn: current approaches and future trends10.1016/j.cossms.2020.100822 ↗
6. Current status and outlook on the clinical translation of biodegradable metals10.1016/j.mattod.2018.05.018 ↗
7. Cell–material interactions in direct contact culture of endothelial cells on biodegradable iron-based stents fabricated by laser powder bed fusion and impact of ion release10.1021/acsami.1c21901 ↗
8. Remotely controlled electrochemical degradation of metallic implants
9. Fabrication of filigree parts via laser powder bed fusion: from melt spots to stents10.1016/j.optlastec.2024.111485 ↗
10. Strut tissue coverage and endothelial cell coverage: a comparison between bare metal stent platforms and platinum chromium stents with and without everolimus-eluting coating10.4244/EIJV6I5A105 ↗
11. Role of endothelial shear stress in stent restenosis and thrombosis: pathophysiologic mechanisms and implications for clinical translation10.1016/j.jacc.2011.10.903 ↗
12. Comparative studies of Tris-HCl, HEPES and NaHCO3/CO2 buffer systems on the biodegradation behaviour of pure Zn in NaCl and SBF solutions10.1016/j.corsci.2019.05.018 ↗
13. Magnesium degradation under physiological conditions – best practice
14. Selecting medium for corrosion testing of bioabsorbable magnesium and other metals – a critical review10.1016/j.corsci.2020.108722 ↗
15. Blood flow in arteries10.1146/annurev.fluid.29.1.399 ↗
16. Fluid shear stress sensing by the endothelial layer10.3389/fphys.2020.00861 ↗
17. Laminar shear stress: mechanisms by which endothelial cells transduce an atheroprotective force10.1161/01.ATV.18.5.677 ↗
18. Wall shear stress - an important determinant of endothelial cell function and structure - in the arterial system in vivo: discrepancies with theory10.1159/000091648 ↗
19. Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications10.1093/eurheartj/ehz551 ↗
20. Corrosion studies on Fe-30Mn-1C alloy in chloride-containing solutions with view to biomedical application10.1002/maco.201709476 ↗
21. Polarization measurements from a rotating disc electrode for characterization of magnesium corrosion10.1016/j.corsci.2015.10.031 ↗
22. Effect of build orientation on the microstructure, mechanical and corrosion properties of a biodegradable high manganese steel processed by laser powder bed fusion10.3390/met11060944 ↗
23. Development of a bioreactor-coupled flow-cell setup for 3D in situ nanotomography of Mg alloy biodegradation10.1021/acsami.3c04054 ↗
24. In vitro corrosion behavior of biodegradable WE43 alloy under various physiological flow velocities10.1007/s10853-024-09617-1 ↗
25. Flow-induced corrosion of absorbable magnesium alloy: In-situ and real-time electrochemical study10.1016/j.corsci.2015.12.020 ↗
26. Flow-induced corrosion behavior of absorbable magnesium-based stents10.1016/j.actbio.2014.08.034 ↗
27. Degradation performance of biodegradable FeMnC(Pd) alloys10.1016/j.msec.2012.10.013 ↗
28. Effects of alloying elements (Mn, Co, Al, W, Sn, B, C and S) on biodegradability and in vitro biocompatibility of pure iron10.1016/j.actbio.2010.11.001 ↗
29. Polarization behavior of pure magnesium under a controlled flow in a NaCl solution10.2320/matertrans.MRA2008011 ↗
30. Design of a pseudo-physiological test bench specific to the development of biodegradable metallic biomaterials10.1016/j.actbio.2007.09.012 ↗
31. Corrosion behavior of different coatings prepared on the surface of AZ80 magnesium alloy in simulated body fluid10.1007/s11665-020-04682-4 ↗
32. Fluid-induced corrosion behavior of degradable zinc for stent application10.1016/j.jmst.2021.02.050 ↗
33. Comparison of in vascular bioreactors and in vivo models of degradation and cellular response of Mg–Zn–Mn stents10.1007/s10439-020-02699-3 ↗
34. Biodegradable metals10.1016/j.mser.2014.01.001 ↗
35. Developing austenitic high-manganese high-carbon steels for biodegradable stent applications: microstructural and mechanical studies10.1016/j.msea.2023.145998 ↗
36. Ion release from magnesium materials in physiological solutions under different oxygen tensions10.1007/s10856-011-4490-5 ↗
37. Corrosion of high purity Mg, Mg2Zn0.2Mn, ZE41 and AZ91 in Hank’s solution at 37°C10.1016/j.corsci.2011.06.030 ↗
38. S. Schrenk, Abbauverhalten degradierbarer Magnesiumlegierungen in körperähnlichen Elektrolyten, Friedrich-Alexander-Universität Erlangen-Nürnberg, 2011. 〈https://open.fau.de/handle/openfau/1916〉.
39. Preparation of SBF with different HCO3- content and its influence on the composition of biomimetic apatites10.1016/j.actbio.2005.11.001 ↗
40. Uncompensated resistance. 2. The effect of reference electrode nonideality10.1021/ac000154x ↗
41. A standard table for predicting equilibrium dissolved oxygen concentrations in Salt Lakes dominated by sodium chloride10.1007/BF02904948 ↗
42. Bio-Logic, Systems and EIS quality indicators, 2018. 〈https://www.biologic.net/documents/systems-and-eis-quality-indicators-electrochemistry/〉.
43. M.E. Orazem, W. Watson, EIS: Measurement Model Program - Version 1.8, (2023). https://doi.org/10.1149/osf.io/g2fjm.10.1149/osf.io/g2fjm ↗
44. Flows over rotating disks and cones10.1146/annurev-fluid-121021-043651 ↗
45. The flow due to a rotating disc10.1017/S0305004100012561 ↗
46. Über laminare und turbulente Reibung10.1002/zamm.19210010401 ↗
47. Levich · 1962
48. Channel and tubular electrodes10.1016/0022-0728(86)90219-6 ↗
49. Viscosity of Liquid Water in the Range -8 °C to 150 °C10.1063/1.555581 ↗
50. Equations for O2 and CO2 solubilities in saline and plasma: combining temperature and density dependences10.1152/japplphysiol.01124.2016 ↗
51. Determination of the diffusion coefficient of oxygen in sodium chloride solutions with a transient pulse technique10.1016/0003-2670(93)80320-K ↗
52. Coronary stents fracture: an engineering approach (review)
53. In vitro degradation behavior of Fe–20Mn–1.2C alloy in three different pseudo-physiological solutions10.1016/j.msec.2015.12.092 ↗
54. Cornell · 2003
55. The use of multiple pseudo-physiological solutions to simulate the degradation behavior of pure iron as a metallic resorbable implant: a surface-characterization study10.1039/C6CP02451C ↗
56. Long-term in vitro degradation behaviour of Fe and Fe/Mg2Si composites for biodegradable implant applications10.1039/C8RA00404H ↗
57. Biodegradation behaviour of Fe-based alloys in Hanks’ balanced salt solutions: part I. material characterisation and corrosion testing
58. Nucleation and crystallization of ferrous phosphate hydrate via an amorphous intermediate10.1021/jacs.3c01494 ↗
59. Tafel slopes and corrosion rates from polarization resistance measurements10.5006/0010-9312-29.10.397 ↗
60. The role of individual components of simulated body fluid on the corrosion behavior of commercially pure Mg10.1016/j.corsci.2018.11.011 ↗
61. Initial formation of corrosion products on pure zinc in simulated body fluid10.1016/j.jmst.2018.05.005 ↗
62. The characterisation of the coated layer at the interface carbon steel-natural salt water by impedance spectroscopy10.1016/S0010-938X(97)00077-2 ↗
63. Impedance study of the passive film on stainless steel 304 in pH 8 carbonate solution
64. Influence of flow on the corrosion inhibition of St52-3 type steel by potassium hydrogen-phosphate10.1016/j.corsci.2009.05.010 ↗
65. Corrosion behavior of the filmed copper surface in saline water under static and jet impingement conditions10.5006/1.3683224 ↗
66. Hydrodynamic effect on the behaviour of a corrosion inhibitor film: characterization by electrochemical impedance spectroscopy10.1016/j.electacta.2005.11.020 ↗
67. Co2 corrosion inhibition of X-120 pipeline steel by a modified imidazoline under flow conditions10.1016/j.corsci.2011.07.028 ↗
68. EIS study on corrosion and scale processes and their inhibition in cooling system media10.1016/j.electacta.2005.02.104 ↗
69. Microstructure and diffusion coefficient of an old corrosion product layer and impact on steel rebar corrosion in carbonated concrete10.1016/j.corsci.2017.06.002 ↗
70. Mechanism of acceleration of iron corrosion by a polylactide coating10.1021/acsami.8b17125 ↗
71. Impact of flow rate on corrosion of cast iron and quality of re-mineralized seawater reverse osmosis (SWRO) membrane product water10.1016/j.desal.2013.05.001 ↗
72. Calcium phosphate deposition on iron in oxygen-containing neutral aqueous solutions: an electrochemical approach10.1021/la00085a050 ↗
73. The influence of flow rate on corrosion of mild steel in hot tap water10.1016/j.corsci.2015.05.007 ↗
74. Corrosion rates of stainless steel under shear stress measured by a novel parallel-plate flow chamber10.1002/jbm.b.30367 ↗
75. Fundamentals of metallic
76. Aerobic and anaerobic oxidation of ferrous ions in near-neutral solutions10.1016/j.chemosphere.2023.138955 ↗
77. Biodegradation behaviour of Fe-based alloys in Hanks’ balanced salt solutions: part II. The evolution of local pH and dissolved oxygen concentration at metal interface
78. Formation of siderite and vivianite and the pore-water composition of a Recent bog sediment in Denmark10.1016/0009-2541(80)90088-1 ↗
79. Influence of phosphate on corrosion products of iron in chloride-polluted-concrete-simulating solutions: ferrihydrite vs green rust10.5006/1.3277637 ↗
80. Diffusion of ions in sea water and in deep-sea sediments10.1016/0016-7037(74)90145-8 ↗
81. Fe-Mn alloys for metallic biodegradable stents: degradation and cell viability studies10.1016/j.actbio.2009.11.025 ↗