Electrospun graphene oxides reinforced polylactic acid /polycaprolactone shape memory membranes for antibacterial tracheal stents
Source abstract
Abstract
Electrospun shape-memory polymer (SMP) membranes were engineered from polylactic acid/polycaprolactone (PLA/PCL) reinforced with graphene oxide (GO) for potential antibacterial tracheal stent applications. This research integrated shape memory behavior with drug release kinetics to achieve on-demand antibacterial response, specifically tailored for the infection-susceptible tracheal microenvironment. GO served as both a reinforcing nanofiller and a carrier for vancomycin (VAN) and silver nanoparticles (AgNPs). The effects of GO content (0.1, 0.5, and 1 wt%) on fiber morphology, mechanical properties, thermal behavior, hydrophilicity, and shape-memory performance were systematically investigated. The results indicated that the incorporation of 0.1 wt% GO yielded optimal mechanical reinforcement and shape recovery efficiency (100% fixity/recovery ratio, recovery time ∼8 s). Notably, the shape memory effect (SME) actively enhanced membrane hydrophilicity with a decreased contact angle from ∼127° to ∼87° and facilitated a more rapid release of VAN. The drug-loaded membranes exhibited sustained release profiles and potent antibacterial activity against Staphylococcus aureus and Streptococcus pneumoniae. Biocompatibility tests confirmed the enhanced adhesion and viability of rat tracheal epithelial cells on GO-reinforced membranes, with Ag@GO showing better cytocompatibility to VAN@GO. This work demonstrated an antibacterial strategy for advanced tracheal stents.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Tracheal and airway disorders · Electrospun Nanofibers in Biomedical Applications · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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