Functionalization of calcium-deficient nanohydroxyapatite improves the mechanical properties of 3D printed biopolymer nanocomposites
Source abstract
Abstract
Agglomerations of nanoparticles in a polymer matrix can drastically reduce the mechanical properties of a polymer nanocomposite , especially its strength . The grafting of nanoparticle surfaces with suitable functional groups can provide improved dispersion and stronger interfacial bonding, improving the fracture resistance of the nanocomposite. In this study, calcium-deficient nanohydroxyapatite (nHA) particles were functionalized with an amino acid-based urethane methacrylate (lysine urethane methacrylate, LUM) and subsequently reacted with hydroxyethyl methacrylate . We mixed these functionalized nHA particles with resin, composed of methacrylated acrylated epoxidized soybean oil, methacrylated isosorbide , and triethylene glycol dimethacrylate , and 3D-printed nanocomposites using masked stereolithography . We hypothesized that the functionalized nanoparticles would enhance the mechanical performance of the 3D-printed nanocomposites due to the greater dispersion and stronger interface. Flexural, tensile, compression and Mode-I fracture toughness test specimens were fabricated using a mSLA printer and tested following ASTM standards. The LUM functionalization of nHA improved the dispersion and increased the viscosity of the uncured nanocomposite ink. The flexural fracture strength, yield strength, and mode-I fracture toughness values were increased by 10 %, 30 %, and 11 %, respectively. The LUM improved the strength and fracture toughness by providing a stronger, more stable interface, resisting debonding between the matrix and particles, allowing for greater plastic deformation .
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Additive Manufacturing and 3D Printing Technologies · Bone Tissue Engineering Materials · 3D Printing in Biomedical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (54)
Show source-provided references
1. Biocompatibility and osteogenicity of degradable Ca-deficient hydroxyapatite scaffolds from calcium phosphate cement for bone tissue engineering10.1016/j.actbio.2008.07.018 ↗
2. In vivo approach of calcium deficient hydroxyapatite filler as bone induction factor10.1016/j.msec.2019.02.060 ↗
3. In vivo biocompatibility of new nano-calcium-deficient hydroxyapatite/poly-amino acid complex biomaterials10.2147/IJN.S90273 ↗
4. Polymer grafted hydroxyapatite whisker as a filler for dental composite resin with enhanced physical and mechanical properties10.1016/j.msec.2013.08.029 ↗
5. Yudyanto, Physical and mechanical properties of hydroxyapatite/polyethylene glycol nanocomposites10.1016/j.matpr.2020.11.511 ↗
6. Osteoconductive and electroactive carbon nanofibers/hydroxyapatite nanocomposite tailored for bone tissue engineering: in vitro and in vivo studies10.1038/s41598-020-71455-3 ↗
7. Correlation between cell attachment areas after 2h of culture and osteogenic differentiation activity of rat mesenchymal stem cells on hydroxyapatite substrates with various surface properties10.1016/j.bbrc.2012.11.054 ↗
8. The effectiveness of functionalized nano-hydroxyapatite filler on the physical and mechanical properties of novel dental restorative composite10.1080/00914037.2019.1631822 ↗
9. Modification of hydroxyapatite Nanosurfaces for enhanced Colloidal stability and improved interfacial adhesion in nanocomposites10.1021/cm061139x ↗
10. Functionalized calcium orthophosphates (CaPO4) and their biomedical applications10.1039/C9TB01976F ↗
11. Breaking the nanoparticle loading–dispersion Dichotomy in polymer nanocomposites with the Art of Croissant-Making10.1021/acsnano.8b02877 ↗
12. Glass formation and stability of polystyrene–fullerene nanocomposites10.1016/j.molliq.2009.10.003 ↗
13. Understanding the role of cohesive interaction in mechanical behavior of a glassy polymer10.1021/acs.macromol.0c00067 ↗
14. In situ generation of hydroxyapatite on biopolymer particles for fabrication of bone scaffolds owning bioactivity10.1021/acsami.0c13768 ↗
15. Chemical functionalization for improving dispersion and interfacial bonding of halloysite nanotubes in epoxy nanocomposites10.1177/0954008314528226 ↗
16. Effect of hydrogen functionalization on interfacial behavior of defective-graphene/polymer nanocomposites10.1002/pc.25454 ↗
17. Functionalization of MWNTs using polyacryloyl chloride and the properties of CNT–epoxy matrix nanocomposites10.1016/j.compscitech.2008.08.011 ↗
18. Fracture mechanisms of epoxy filled with ozone functionalized multi-wall carbon nanotubes10.1016/j.compscitech.2011.07.016 ↗
19. Comparison to mechanical properties of epoxy nanocomposites reinforced by functionalized carbon nanotubes and graphene nanoplatelets10.1016/j.compositesb.2018.11.011 ↗
20. Surface structure and properties of calcium hydroxyapatite modified by hexamethyldisilazane10.1006/jcis.1998.5634 ↗
21. Surface modification of nano-apatite by grafting organic polymer10.1016/S0142-9612(98)00033-7 ↗
22. Problem of hydroxyapatite dispersion in polymer matrices: a review10.1007/s10856-009-3696-2 ↗
23. Enhanced in vitro mineralization and in vivo osteogenesis of composite scaffolds through controlled surface grafting of l-lactic acid oligomer on nanohydroxyapatite10.1021/acs.biomac.5b01543 ↗
24. A study on grafting and characterization of HMDI-modified calcium hydrogenphosphate10.1016/S0142-9612(01)00070-9 ↗
25. The effect of surface-modified nano-hydroxyapatite on biocompatibility of poly(ε-caprolactone)/hydroxyapatite nanocomposites10.1016/j.eurpolymj.2007.02.030 ↗
26. Effect of n-HA with different surface-modified on the properties of n-HA/PLGA composite10.1016/j.apsusc.2012.06.091 ↗
27. Effect of l-lysine-assisted surface grafting for nano-hydroxyapatite on mechanical properties and in vitro bioactivity of poly(lactic acid-co-glycolic acid)10.1177/0885328215584491 ↗
28. A study on the grafting reaction of isocyanates with hydroxyapatite particles10.1002/(SICI)1097-4636(19980605)40:3<358::AID-JBM3>3.0.CO;2-E ↗
29. Lysineurethanedimethacrylate—a novel generation of amino acid based monomers for bone cements and tissue repair10.1016/S0142-9612(01)00411-2 ↗
30. Resorbable nanocomposites with bone-like strength and enhanced cellular activity10.1039/C7TB00657H ↗
31. Superoxide and bone resorption10.1016/8756-3282(94)90821-4 ↗
32. Oxidative stress, free radicals and bone remodeling10.1515/CCLM.2008.302 ↗
33. Acrylated epoxidized soybean oil/hydroxyapatite-based nanocomposite scaffolds prepared by additive manufacturing for bone tissue engineering10.1016/j.msec.2020.111400 ↗
34. mSLA-based 3D printing of acrylated epoxidized soybean oil - nano-hydroxyapatite composites for bone repair10.1016/j.msec.2021.112456 ↗
35. Extrudable hydroxyapatite/plant oil-based biopolymer nanocomposites for biomedical applications: mechanical testing and modeling10.1016/j.matdes.2019.107790 ↗
36. Mechanical properties of nanocomposite biomaterials improved by extrusion during direct ink writing10.1016/j.jmbbm.2020.103653 ↗
37. Effects of biopolymer functionalization and nanohydroxyapatite heat treatment on the tensile and thermomechanical properties of Bone-Inspired 3D printable nanocomposite biomaterials10.1016/j.matdes.2023.111587 ↗
38. Enhanced mechanical performance of mSLA-printed biopolymer nanocomposites due to phase functionalization10.1016/j.jmbbm.2022.105450 ↗
39. Enhanced mechanical properties of 3D printed nanocomposites composed of functionalized plant-derived biopolymers and calcium-deficient hydroxyapatite nanoparticles10.3389/fmats.2022.833065 ↗
40. Impact of side chain polarity on non-stoichiometric nano-hydroxyapatite surface functionalization with amino acids10.1038/s41598-018-31058-5 ↗
41. Poly(L-lactide) nanocomposites containing poly(D-lactide) grafted nanohydroxyapatite with improved interfacial adhesion via stereocomplexation10.1016/j.jmbbm.2017.10.036 ↗
42. 3D printing with polymers: challenges among expanding options and opportunities10.1016/j.dental.2015.09.018 ↗
43. Digital light processing 3D printing of conductive complex structures
44. Polymers for 3D printing and customized additive manufacturing10.1021/acs.chemrev.7b00074 ↗
45. Development of 3D printable formulations containing CNT with enhanced electrical properties10.1016/j.polymer.2016.12.051 ↗
46. Investigation of the fracture mechanism and mechanical properties of polystyrene/silica nanocomposite in various silica contents10.1007/s10853-011-5513-9 ↗
47. Morphology, tensile and fracture characteristics of epoxy-alumina nanocomposites10.1016/j.msea.2010.05.038 ↗
48. Continuous fibre composites with a nanocomposite matrix: improvement of flexural and compressive strength at elevated temperatures10.1016/j.compositesa.2006.09.010 ↗
49. Nanocomposite matrix for increased fibre composite strength10.1016/j.polymer.2005.08.003 ↗
50. Strength of unidirectional glass/epoxy composite with silica nanoparticle-enhanced matrix10.1016/j.compscitech.2008.02.026 ↗
51. Surface modification of calcium hydroxyapatite with hexyl and decyl phosphates10.1016/S0927-7757(96)03876-9 ↗
52. Surface modification of hydroxyapatite. Part I. Dodecyl alcohol10.1016/S0142-9612(03)00239-4 ↗
53. Water absorption characteristics of dental composites incorporating hydroxyapatite filler10.1016/S0142-9612(01)00331-3 ↗
54. Physical and biological evaluations of sintered hydroxyapatite/silicone composite with covalent bonding for a percutaneous implant material10.1002/jbm.b.10002 ↗