Piezoelectric actuator: Searching inspiration in nature for osteoblast stimulation
Source abstract
Abstract
Bone is a composite with piezoelectric properties. Bone mass and structure are dependent on mechanical stress and adaptive response at cellular and tissue levels, but the role piezoelectricity plays in bone physiology is yet to be understood. Physical activity enhances bone density, through mechanical stimulation. Osteocytes and osteoblasts are essential for mechanosensing and mechanotransduction. Strategies have been tested for mechanical stimulation of cells and tissues in vitro. The aim of this work was to experimentally validate the use of piezoelectric materials as a mean of directly straining bone cells by converse piezoelectric effect. To estimate the magnitude of stress/strain, finite numerical models were applied and theoretical data was complemented by optic experimental data. Osteoblasts were then grown on the surface of the piezoelectric material and cell response studied. © 2010 Elsevier Ltd.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Spaceflight effects on biology · Cellular Mechanics and Interactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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