A novel expandable porous composite based on acetalized polyvinyl alcohol and calcium sulfate used for injectable bone repair materials
Source abstract
Abstract
Abstract Calcium sulfate hemihydrate (CaSO4·1/2H2O; CSH) has been used for filling bone defects because of its excellent biocompatibility and injectability. Researchers have devoted in improving its performance to adapt to various demands. However, up to now, no studies have reported bone cement with expandable ability. In this study, a novel expandable bone cement was prepared with acetalized polyvinyl alchol porous material (APVA-PM) and CSH. By controlling the content of APAV-PM, composite cements with different structures and morphology were obtained and investigated by using SEM, FT-IR, XRD. The physical properties including setting time, porosity and expansion ratio were studied. CSH/APVA-PM bone cement could produce volume expansion in the setting process and form a porous structure after curing. The setting time decreased with the increase of the volume fraction of APVA-PM. APVA-PM improved the toughness of calcium sulfate cement, thus overcoming the present mechanical limitations. In vitro experiments demonstrated the CSH/APVA-PM bone cement did not show cytotoxicity and the porous structure allowed the rat bone marrow stem cells (BMSCs) to grow into the pores. Therefore, CSH/APVA-PM bone cement appeared to be useful for bone tissue engineering and can potentially serve as a new filling material.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty · Dental Implant Techniques and Outcomes
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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