Synergistic reinforcement of polydopamine-coated hydroxyapatite and BMP2 biomimetic peptide on the bioactivity of PMMA-based cement
Source abstract
Abstract
Abstract To be better used as implant materials in bone regeneration, bioactivity and osteogenesis of poly(methyl methacrylate) (PMMA)-based bone cement need to be further enhanced. In this study, bioactive hydroxyapatite (HA) nanoparticle decorated with polydopamine (pDA) and BMP2 mimicking peptide (serine-serine-valine-proline-threonine, SSVPT) was incorporated into PMMA-based cement (p x -HA/PMMA). The presence of pDA layer on HA surface could keep the mechanical property of p x -HA/PMMA cements comply with the requirement of clinical application. More importantly, the p x -HA/PMMA cement exhibited excellent biomechanical property with enhanced interfacial adhesion between cement and swine femur. Biomineralization and cell experiment in vitro showed that the incorporation of pDA-coated HA and SSVPT can synergistically enhance the bioactivity of p x -HA/PMMA cement for regeneration and provide an attractive strategy to reconstruction of load-bearing bone.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Polymer Surface Interaction Studies · Orthopaedic implants and arthroplasty
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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