An in-situ formable and fibrils-reinforced polysaccharide composite hydrogel by self-crosslinking with dual healing ability
Source abstract
Abstract
Abstract Novel in-situ formable and fibrils-reinforced polysaccharide-based composite hydrogels with dual healing ability were prepared by a facile, one-pot approach with maleilated chitosan (CS-MA) and thiol derivatised sodium alginate (SA-SH), via Michael addition reaction and ionic interaction. The unique fibrils network working as reinforcement fillers were attributed to the electrostatic interaction of CS-MA with SA-SH. This CS-MA/SA-SH composite hydrogel can self-heal cracks through dynamic disulfide exchange in 12 h at 37 °C without any external intervention. Noteworthy, fast healing ability inside hydrogels or with porous scaffolds within 1 min can be obtained via the introduction of calcium ions. Moreover, tunable shapes can also be obtained via dual cross-linking, providing advantages to optimize the fibrils-reinforced composite gels system for more biomedical applications. In addition, cell viability and proliferation showed that both of the gels before and after healing with Ca2+ possessed good cytocompatibility.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · 3D Printing in Biomedical Research · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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