Halloysite nanotube nanocomposite hydrogels with tunable mechanical properties and drug release behavior
Source abstract
Abstract
Abstract Nanocomposite hydrogels with tunable mechanical properties and drug release behavior were prepared by halloysite nanotube (HNT), oligo(trimethylene carbonate)–poly(ethylene glycol)–oligo(trimethylene carbonate) diacrylate (TPT), and alginate sodium (AG). The mechanical properties of the hydrogel were greatly enhanced by the addition of small amount of HNT (2 wt%). The drug release behavior of the hydrogels was examined using bovine serum albumin (BSA) as model drug, and TPT hydrogel showed a fickcian diffusion controlled release mechanism, while the BSA transport mechanism in TPT-HNT, TPT-AG, and TPT-AG-HNT hydrogels were anomalous transport. The cytocompatibility of the hydrogel were verified by the MTT assay, and the hydrogel showed comparable cytocompatibility with the widely recognized poly(ethylene glycol) hydrogel.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Clay minerals and soil interactions · Hydrogels: synthesis, properties, applications · Therapeutic Uses of Natural Elements
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (26)
Show source-provided references
1. PEG/clay nanocomposite hydrogel: a mechanically robust tissue engineering scaffold10.1039/c0sm00067a ↗
2. Zach Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release10.1016/j.jconrel.2008.06.008 ↗
3. Design of a self-cleaning thermoresponsive nanocomposite hydrogel membrane for implantable biosensors10.1016/j.actbio.2010.01.039 ↗
4. Guest-molecule-directed assembly of mesostructured nanocomposite polymer/organoclay hydrogels10.1002/adfm.201002138 ↗
5. Polyampholytes superabsorbent nanocomposites with excellent gel strength10.1016/j.compscitech.2007.02.009 ↗
6. Nanocomposite hydrogels: a unique organic-inorganic network structure with extraordinary mechanical, optical, and swelling/de-swelling properties10.1002/1521-4095(20020816)14:16<1120::AID-ADMA1120>3.0.CO;2-9 ↗
7. Halloysite clay nanotubes for controlled release of protective agents10.1021/nn800259q ↗
8. Characterisation of halloysite for use as a microtubular drug delivery system10.1016/S0378-5173(02)00274-0 ↗
9. Surface-engineered nanocontainers for entrapment of corrosion inhibitors10.1002/adfm.200601226 ↗
10. Halloysite nanotubes as biomimetic nanoreactors10.1002/smll.200400120 ↗
11. Novel polyamide nanocomposites based on silicate nanotubes of the mineral halloysite10.1016/j.compscitech.2008.10.011 ↗
12. Mechanical behavior and essential work of fracture of halloysite nanotubes filled polyamide 6 nanocomposites10.1016/j.compscitech.2011.08.019 ↗
13. Enhanced adsorption of ammonium using hydrogel composites based on chitosan and halloysite10.1080/10601320903394421 ↗
14. Novel polymer nanocomposite hydrogel with natural clay nanotubes10.1007/s00396-012-2588-z ↗
15. Structurally enhanced hydrogel nanocomposites with improved swelling and mechanical properties10.1080/10601325.2012.631442 ↗
16. A novel single precursor-based biodegradable hydrogel with enhanced mechanical properties10.1039/b912102a ↗
17. Polymeric protein delivery systems10.1016/j.progpolymsci.2007.04.001 ↗
18. Highly stretchable and tough hydrogels10.1038/nature11409 ↗
19. Hydrogel containing hyaluronan and aliphatic oligo-carbonate moieties with tunable physical properties for potential application in protein release10.1016/j.carbpol.2011.06.048 ↗
20. Preparation and characterization of a biodegradable hydrogel containing oligo(2,2-dimethyltrimethylene carbonate) moieties with tunable properties10.1039/C2RA22622G ↗
21. Mechanism of forming organic/inorganic network structures during in-situ free-radical polymerization in PNIPA-clay nanocomposite hydrogels10.1021/ma047431c ↗
22. A strong bio-inspired layered PNIPAM-clay nanocomposite hydrogel10.1002/anie.201200267 ↗
23. Biodegradable nanocomposite hydrogel structures with enhanced mechanical properties prepared by photo-crosslinking solutions of poly(trimethylene carbonate)–poly(ethylene glycol)-poly(trimethylene carbonate) macromonomers and nanoclay particles10.1016/j.actbio.2012.09.014 ↗
24. Progress in the development of interpenetrating polymer network hydrogels10.1002/pat.1134 ↗
25. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC)10.1016/S0169-409X(01)00112-0 ↗
26. Cytocompatibility and uptake of halloysite clay nanotubes10.1021/bm9014446 ↗