Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property
Source abstract
Abstract
Abstract Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e 6 (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS 2 ) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS 2 –Ir. We observed that MoS 2 -Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.
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Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Graphene and Nanomaterials Applications · Luminescence and Fluorescent Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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