journal article·2016-04

Microstructures: Mechanisms and Microenvironment Investigation of Cellularized High Density Gradient Collagen Matrices via Densification (Adv. Funct. Mater. 16/2016)

Tyler Novak, Benjamin Seelbinder, Celina M. Twitchell, Corrinus C. van Donkelaar, Sherry L. Voytik‐Harbin, Corey P. Neu

Advanced Functional Materials· Volume 26· Issue 16
Publisher page

Abstract

Biomaterials often have characteristic spatial gradients in physical properties that lead to specialized function. On page 2617, C. P. Neu and co-workers form gradient matrices of natural biopolymers using a densification process that exudes fluid from the structure, leading to a reproducible reorganization of collagen and embedded cells. High-density regions show increased fibril packing, mechanical properties, and fibril thickness, on par with values observed in native tissues like articular cartilage.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Collagen: Extraction and Characterization

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Affiliations

Department of Biomedical Engineering Purdue University West Lafayette IN USA

Department of Biomedical Engineering Eindhoven University of Technology Eindhoven The Netherlands

Department of Basic Medical Sciences Purdue University West Lafayette IN USA

Department of Mechanical Engineering University of Colorado Boulder CO USA

References

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