Decorated of silver nanoparticles over Arabic gum modified magnetic nanoparticles: Evaluation of its antioxidant and its therapeutic effects on cervical cancer

In the current work, we report the bio-inspired formulation of silver NPs fabricated over Arabic gum (AG) functionalized magnetic nanocomposite (Fe 3 O 4 @AG/Ag NPs) for the treatment of cervical cancer. In the stepwise modification approach, the pre-synthesized Fe 3 O 4 NPs were encapsulated by the Arabic gum polar organomolecules, followed by the decoration of in-situ green synthesized silver NPs over the composite. The final bio-material was characterized by various analytical techniques such as XRD, EDX, ICP-OES, TEM, FE-SEM, and FT-IR. The FE-SEM findings validate the spherical shape of the Fe 3 O 4 @AG/Ag NPs, which range in size from 20 to 35 nm. An assessment was conducted on the characteristics of Fe 3 O 4 @AG/Ag NPs in relation to prevalent human cervical cancer cells. The DPPH free radical antioxidant assay demonstrates the notable antioxidant characteristics of Fe3O4@AG/Ag NPs. The Fe 3 O 4 @AG/Ag NPs exhibited IC 50 values of 115, 90, 119, and 80 when tested against SiHa, C-33 A, Ca Ski, and LM-MEL-41 cells, respectively. The anti-human cervical cancer effect of Fe 3 O 4 @AG/Ag NPs appears to be a result of their antioxidant properties. According to the findings mentioned above, there is a potential for the newly created Fe 3 O 4 @AG/Ag NPs to be utilized as an innovative chemotherapeutic treatment or supplement for managing cervical cancer after the conclusion of clinical trials with human participants.