Effects of Dynamic Flow Rates on the In Vitro Bio-Corrosion Behavior of Zn-Cu Alloy
Source abstract
Abstract
In the complicated real physiological environment in vivo, body fluids and blood are constantly replenished and move dynamically, and therefore, the dynamic impacts of bodily fluids and blood need to be considered in the evaluation of biodegradable materials. However, little research has been conducted on the impact of dynamic flowing circumstances on the corrosion characteristics of zinc-based alloys, particularly at high flow rates. The effects of various flow rates on the bio-corrosion behavior of the Zn-Cu alloy are thoroughly explored in this study. A model is developed using finite element analysis to investigate the impacts of flow rates and fluid-induced shear stress. The results reveal that the corrosion process of the Zn-Cu alloy is significantly accelerated by a higher flow rate, and a large fluid-induced shear stress caused by the boundary effect is found to promote corrosion. Furthermore, the empirical power function between the average flare rates in Hank’s solution and the corrosion rates of the Zn-Cu alloy is established by numerical simulation. The results provide insightful theoretical and experimental guidance to improve and evaluate the efficacy and lifespan of biomedical zinc-based alloy implants.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Corrosion Behavior and Inhibition · Metallurgy and Material Science
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Materials Science and Engineering, Southeast University, Nanjing 211189, China
Jiangsu Key Laboratory for Advanced Metallic Materials, Southeast University, Nanjing 211189, China
Department of Physics, City University of Hong Kong, Hong Kong, China
Department of Materials Science and Engineering, City University of Hong Kong, Hong Kong, China
Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China
Funding
National Natural Science Foundation of China · State Key Program of the National Natural Science Foundation of China · Suzhou Science and Technology Project · Open Research Fund of Jiangsu Key Laboratory for Advanced Metallic Materials, Southeast University · Postgraduate Research and Practice Innovation Program of Jiangsu Province · City University of Hong Kong Donation Research Grants
References (42)
Show source-provided references
1. Biodegradable synthetic polymer in orthopaedic application: A review10.1016/j.matpr.2022.12.254 ↗
2. Biodegradable metals10.1016/j.mser.2014.01.001 ↗
3. Insight into the Corrosion Behaviour and Degradation Mechanism of Pure Zinc in Simulated Body Fluid10.1016/j.corsci.2020.109071 ↗
4. Design and Characterizations of Novel Biodegradable Ternary Zn-based Alloys with IIA Nutrient Alloying Elements Mg, Ca and Sr10.1016/j.matdes.2015.05.089 ↗
5. Initial Formation of Corrosion Products On Pure Zinc in Simulated Body Fluid10.1016/j.jmst.2018.05.005 ↗
6. Evolution of the Degradation Mechanism of Pure Zinc Stent in the One-Year Study of Rabbit Abdominal Aorta Model10.1016/j.biomaterials.2017.08.022 ↗
7. Current status and perspectives of zinc-based absorbable alloys for biomedical applications10.1016/j.actbio.2019.07.034 ↗
8. Zinc-Based Alloys for Degradable Vascular Stent Applications10.1016/j.actbio.2018.03.005 ↗
9. Zinc Exhibits Ideal Physiological Corrosion Behavior for Bioabsorbable Stents10.1002/adma.201300226 ↗
10. Challenges in the Use of Zinc and its Alloys as Biodegradable Metals: Perspective from Biomechanical Compatibility10.1016/j.actbio.2019.07.038 ↗
11. In Vitro Investigation of Ultra-Pure Zn and its Mini-Tube as Potential Bioabsorbable Stent Material10.1016/j.matlet.2015.06.107 ↗
12. A Study on the Effect of Zinc Oxide and Zinc Peroxide Nanoparticles to Enhance Angiogenesis-Pro-Angiogenic Grafts for Tissue Regeneration Applications10.1016/j.matdes.2017.07.023 ↗
13. Metallic Zinc Exhibits Optimal Biocompatibility for Bioabsorbable Endovascular Stents10.1016/j.msec.2015.07.022 ↗
14. Influence of Thermal Treatment on Microstructure, Mechanical and Degradation Properties of Zn–3Mg Alloy as Potential Biodegradable Implant Material10.1016/j.matdes.2015.06.181 ↗
15. Zn-Mg and Zn-Cu Alloys for Stenting Applications: From Nanoscale Mechanical Characterization to in Vitro Degradation and Biocompatibility
16. Characterization of Nano Precipitate Phase in an As-Extruded Zn-Cu Alloy10.1016/j.scriptamat.2021.113907 ↗
17. Effects of Ag, Cu or Ca Addition on Microstructure and Comprehensive Properties of Biodegradable Zn-0.8Mn Alloy10.1016/j.msec.2019.02.044 ↗
18. Design and Characterizations of Novel Biodegradable Zn-Cu-Mg Alloys for Potential Biodegradable Implants10.1016/j.matdes.2016.12.075 ↗
19. Role of Cu Element in Biomedical Metal Alloy Design10.1007/s12598-019-01245-y ↗
20. Copper-Induced Vascular Endothelial Growth Factor Expression and Wound Healing10.1152/ajpheart.01015.2001 ↗
21. Potential Biodegradable Zn-Cu Binary Alloys Developed for Cardiovascular Implant Applications10.1016/j.jmbbm.2017.05.013 ↗
22. Copper-Containing Mesoporous Bioactive Glass Scaffolds with Multifunctional Properties of Angiogenesis Capacity, Osteostimulation and Antibacterial Activity10.1016/j.biomaterials.2012.09.066 ↗
23. Research on a Zn-Cu Alloy as a Biodegradable Material for Potential Vascular Stents Application10.1016/j.msec.2016.06.082 ↗
24. Alloying design of biodegradable zinc as promising bone implants for load-bearing applications10.1038/s41467-019-14153-7 ↗
25. Investigation of Zinc-Copper Alloys as Potential Materials for Craniomaxillofacial Osteosynthesis Implants10.1016/j.msec.2019.109826 ↗
26. Influence of Model Environment Complexity On Corrosion Mechanism of Biodegradable Zinc Alloys10.1016/j.corsci.2021.109520 ↗
27. Recent Advances On the Mechanical Behavior of Zinc Based Biodegradable Metals Focusing On the Strain Softening Phenomenon10.1016/j.actbio.2022.08.041 ↗
28. Biodegradable Zinc-Iron Alloys: Complex Study of Corrosion Behavior, Mechanical Properties and Hemocompatibility10.1016/j.pnsc.2021.01.002 ↗
29. In Vitro and in Vivo Studies on Zinc-Hydroxyapatite Composites as Novel Biodegradable Metal Matrix Composite for Orthopedic Applications10.1016/j.actbio.2018.03.007 ↗
30. Biocorrosion Behavior of Micro-Arc-Oxidized AZ31 Magnesium Alloy in Different Simulated Dynamic Physiological Environments10.1016/j.surfcoat.2019.01.052 ↗
31. Effect of Flow Velocity on Corrosion Behavior of AZ91D Magnesium Alloy at Elbow of Loop System10.1016/S1003-6326(16)64414-X ↗
32. Effect of High Flow Velocity on Corrosion Behavior of Ni Based and Ni-Fe Based Alloys in Supercritical Water Oxidation Environment10.1016/j.supflu.2020.105126 ↗
33. Effects of Flow Velocity on the Corrosion Behaviour of Super 13Cr Stainless Steel in ultra-HTHP CO2–H2S Coexistence Environment10.1016/j.corsci.2022.110235 ↗
34. Comparative Corrosion Behavior of Zn with Fe and Mg in the Course of Immersion Degradation in Phosphate Buffered Saline10.1016/j.corsci.2016.05.039 ↗
35. Microstructures, Mechanical Properties and in Vitro Corrosion Behavior of Biodegradable Zn Alloys Microalloyed with Al, Mn, Cu, Ag and Li Elements10.1016/j.jmst.2021.06.049 ↗
36. Influences of Albumin On in Vitro Corrosion of Pure Zn in Artificial Plasma10.1016/j.corsci.2019.04.003 ↗
37. The Biological Inorganic Chemistry of Zinc Ions10.1016/j.abb.2016.04.010 ↗
38. Degradation of Zinc in Saline Solutions, Plasma, and Whole Blood10.1002/jbm.b.33458 ↗
39. Ex Vivo Blood Vessel Bioreactor for Analysis of the Biodegradation of Magnesium Stent Models with and without Vessel Wall Integration10.1016/j.actbio.2016.12.039 ↗
40. Absorbable Magnesium-Based Stent: Physiological Factors to Consider for in Vitro Degradation Assessments10.1093/rb/rbu015 ↗
41. Assessing the Corrosion of Biodegradable Magnesium Implants: A Critical Review of Current Methodologies and their Limitations10.1016/j.actbio.2011.11.014 ↗
42. Effects of Different Concentrations of BSA on in Vitro Corrosion Behavior of Pure Zinc in Artificial Plasma10.1021/acsbiomaterials.2c00894 ↗