journal article·2025-05-17Open access

Research Progress of the Coatings Fabricated onto Titanium and/or Titanium Alloy Surfaces in Biomaterials for Medical Applications for Anticorrosive Applications

Qin Rao, Jinshuang Zhang, Yaqing Chen, Yujin Yang, Xu Chen, Donghao Liu, Ruilu Zhu, Ang Li, Yanping Lv, Shunli Zheng

Coatings· Volume 15· Issue 5

Abstract

Titanium (Ti) and its alloys have attracted more interest, as they are widely employed as biomaterials due to their great biocompatibility, excellent strength ratio, and lightweight. However, corrosion occurs slowly due to an electrochemical reaction once the Ti material has been placed in the human body, contributing to infection and failure of implants in medical applications. Thus, the corrosion phenomenon has caused great concern in the biomedical field. It is desirable to make the surface modification to provide better corrosion resistance. The fabrication techniques of the coatings fabricated onto Ti and/or Ti alloy surfaces have been reported, including sol–gel, annealing, plasma spraying, plasma immersion ion implantation, physical vapor deposition, chemical vapor deposition, anodization, and micro-arc oxidation. This review first describes the corrosion types, including localized corrosion (both pitting and crevice corrosion), galvanic corrosion, selective leaching, stress corrosion cracking (SCC), corrosion fatigue (CF), and fretting corrosion. In the second part, the effects of corrosion on the human body were discussed, and the primary cause for clinical failure and allergies has been identified as the excessive release of poisonous and dangerous metal ions (Co, Ni, and Ti) from corroded implants into bodily fluids. The inclusion and exclusion criteria during the selection of literature are described in the third section. In the last section, we emphasized the current research progress of Ti alloy (particularly Ti6Al4V alloy) coatings in biomaterials for medical applications involving dental, orthopedic, and cardiovascular implants for anticorrosive applications. However, there are also several problems to explore and address in future studies, such as the release of excessive metal ions, etc. This review will draw attention to both researchers and clinicians, which could help to increase the coatings fabricated onto Ti and/or Ti alloy surfaces for anticorrosive applications in biomaterials for medical applications.
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Research context

OpenAlex topics: Orthopaedic implants and arthroplasty · Titanium Alloys Microstructure and Properties · Bone Tissue Engineering Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei 230032, China

Funding

National Natural Science Foundation of China · Key Research and Development Program of Anhui Province · College Young and Middle-Aged Teachers Training Action Project of Anhui Education Department · Research Fund of Anhui Institute of Translational Medicine · Natural Science Foundation of Anhui Province · Anhui Medical University Basic and Clinical Collaborative Research Enhancement Program · Anhui Medical University · 2023 Disciplinary Construction Project in the School of Dentistry, Anhui Medical University · 2022 Disciplinary Construction Project in the School of Dentistry, Anhui Medical University · 2021 Disciplinary Construction Project in the School of Dentistry, Anhui Medical University · Research Improvement Program in Stomatologic Hospital and College of Anhui Medical University

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