Poly(Lactide) Nonwoven Fabric with Iron Coating and Its Biological Properties
Source abstract
Abstract
The study investigated the biological properties of a composite material composed of poly(lactide) (PLA) and iron (Fe) produced by sputtering iron onto melt-blown poly(lactide) nonwoven fabrics. The research aimed to thoroughly understand the structure and properties of these materials and their potential applications in biomedicine. We conducted comprehensive chemical and structural analyses using techniques such as microscopic analysis, flame atomic absorption spectrometry (FAAS), and Brunauer–Emmett–Teller (BET) surface area analysis to precisely determine the properties of PLA-Fe materials. Additionally, we evaluated their impact on blood coagulation processes by measuring activated partial thromboplastin time (aPTT) and prothrombin time (PT). We also performed biological analyses on human peripheral blood mononuclear cells (PBM cells) including cell viability and DNA damage. Our results clearly demonstrate that PLA-Fe materials do not significantly influence blood coagulation mechanisms, as they only slightly prolong aPTT time and have no effect on PT. This suggests their potential in biomedical applications. Our results indicate the absence of cyto- and genotoxic properties of PLA-Fe materials against normal blood cells. In conclusion, the research findings suggest that the novel poly(lactide) and iron-sputtered nonwoven fabrics are promising tools in the field of biomedicine, offering potentially innovative therapeutic solutions for the treatment of wounds and injuries.
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Research context
OpenAlex topics: biodegradable polymer synthesis and properties · Bone Tissue Engineering Materials · Additive Manufacturing and 3D Printing Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Łukasiewicz Research Network—Łódź Institute of Technology, Marii Sklodowskiej-Curie 19/27, 90-570 Lodz, Poland
Institute of Polymer and Dye Technology, Faculty of Chemistry, Lodz University of Technology, Stefanowskiego 16, 90-537 Lodz, Poland
Department of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland
Funding
National Science Centre (Poland)
References (84)
Show source-provided references
1. Fabrication of Nanofiber Meltblown Membranes and Their Filtration Properties10.1016/j.memsci.2012.09.050 ↗
2. Karger-Kocsis, J. (1999). Melt Blowing Technology. Polypropylene: An A-Z Reference, Springer.10.1007/978-94-011-4421-6 ↗
3. Nayak, R. (2017). Review of Literature: Meltblowing. Polypropylene Nanofibers: Melt Electrospinning Versus Meltblowing, Springer International Publishing.10.1007/978-3-319-61458-8_6 ↗
4. Meltblown Technology for Production of Polymeric Microfibers/Nanofibers: A Review10.1063/1.5116336 ↗
5. Fabrication and Characterisation of Polypropylene Nanofibres by Meltblowing Process Using Different Fluids10.1007/s10853-012-6742-2 ↗
6. Effects of Poly(ϵ-Caprolactone) on Structure and Properties of Poly(Lactic Acid)/Poly(ϵ-Caprolactone) Meltblown Nonwoven10.1080/03602559.2014.935396 ↗
7. Preparation and Characterization of Magnetic PLA/Fe3O4-g-PLLA Composite Melt Blown Nonwoven Fabric for Air Filtration
8. A Review of Processing Strategies to Generate Melt-Blown Nano/Microfiber Mats for High-Efficiency Filtration Applications10.1177/15280837211019488 ↗
9. Gahan, R., and Zguris, G.C. (2000, January 11–14). A Review of the Melt Blown Process. Proceedings of the Fifteenth Annual Battery Conference on Applications and Advances (Cat. No.00TH8490), Long Beach, CA, USA.
10. Azimi, B., Maleki, H., Zavagna, L., De la Ossa, J.G., Linari, S., Lazzeri, A., and Danti, S. (2020). Bio-Based Electrospun Fibers for Wound Healing. J. Funct. Biomater., 11.10.3390/jfb11030067 ↗
11. Shiffman, M.A., and Low, M. (2021). Electrospun Antimicrobial Wound Dressings: Novel Strategies to Fight Against Wound Infections. Chronic Wounds, Wound Dressings and Wound Healing, Springer International Publishing.10.1007/978-3-030-10698-0 ↗
12. Nonwoven Membranes for Tissue Engineering: An Overview of Cartilage, Epithelium, and Bone Regeneration10.1080/09205063.2019.1620592 ↗
13. The Physico-Chemical Properties of Electrospun Vascular PLLA Scaffolds Modified by the DC Magnetron Sputtering of a Titanium Target10.1088/1742-6596/1115/3/032076 ↗
14. Structural and Surface Compatibility Study of Modified Electrospun Poly(ε-Caprolactone) (PCL) Composites for Skin Tissue Engineering10.1208/s12249-016-0500-8 ↗
15. Mondal, M.I.H. (2022). 20—Nonwoven Materials and Technologies for Medical Applications. Medical Textiles from Natural Resources, Woodhead Publishing.
16. Kubíčková, J., Medek, T., Husby, J., Matonohová, J., Vágnerová, H., Marholdová, L., Velebný, V., and Chmelař, J. (2022). Nonwoven Textiles from Hyaluronan for Wound Healing Applications. Biomolecules, 12.10.3390/biom12010016 ↗
17. Recent Advances in Inorganic Nanomaterials for Wound-Healing Applications10.1039/C9BM00423H ↗
18. A Review on Poly Lactic Acid (PLA) as a Biodegradable Polymer10.1007/s00289-022-04160-y ↗
19. Muller, J., González-Martínez, C., and Chiralt, A. (2017). Combination of Poly(Lactic) Acid and Starch for Biodegradable Food Packaging. Materials, 10.10.3390/ma10080952 ↗
20. Bikiaris, N.D., Koumentakou, I., Samiotaki, C., Meimaroglou, D., Varytimidou, D., Karatza, A., Kalantzis, Z., Roussou, M., Bikiaris, R.D., and Papageorgiou, G.Z. (2023). Recent Advances in the Investigation of Poly(Lactic Acid) (PLA) Nanocomposites: Incorporation of Various Nanofillers and Their Properties and Applications. Polymers, 15.10.3390/polym15051196 ↗
21. Applications of PLA in Modern Medicine
22. Poly(Lactic Acid) Blends in Biomedical Applications10.1016/j.addr.2016.06.014 ↗
23. Kliem, S., Kreutzbruck, M., and Bonten, C. (2020). Review on the Biological Degradation of Polymers in Various Environments. Materials, 13.10.3390/ma13204586 ↗
24. Alam, F., Shukla, V.R., Varadarajan, K.M., and Kumar, S. (2020). Microarchitected 3D Printed Polylactic Acid (PLA) Nanocomposite Scaffolds for Biomedical Applications. J. Mech. Behav. Biomed. Mater., 103.10.1016/j.jmbbm.2019.103576 ↗
25. Sanyang, M.L., and Jawaid, M. (2019). Polylactic Acid (PLA)-Based Nanocomposites: Processing and Properties. Bio-Based Polymers and Nanocomposites: Preparation, Processing, Properties & Performance, Springer International Publishing.10.1007/978-3-030-05825-8 ↗
26. Poly (Lactic Acid) Blends: Processing, Properties and Applications10.1016/j.ijbiomac.2018.12.002 ↗
27. Physical and Mechanical Properties of PLA, and Their Functions in Widespread Applications—A Comprehensive Review10.1016/j.addr.2016.06.012 ↗
28. Auras, R.A., Lim, L.-T., Selke, S.E.M., and Tsuji, H. (2022). Poly(Lactic Acid): Synthesis, Structures, Properties, Processing, Applications, and End of Life, John Wiley & Sons.10.1002/9781119767480 ↗
29. Wound Dressings: Current Advances and Future Directions10.1002/app.47738 ↗
30. Masutani, K., and Kimura, Y. (2014). PLA Synthesis. From the Monomer to the Polymer. Poly(lactic acid) Science and Technology, Royal Society of Chemistry.10.1039/9781782624806-00001 ↗
31. Hu, Y., Daoud, W.A., Cheuk, K.K.L., and Lin, C.S.K. (2016). Newly Developed Techniques on Polycondensation, Ring-Opening Polymerization and Polymer Modification: Focus on Poly(Lactic Acid). Materials, 9.10.3390/ma9030133 ↗
32. Synthesis and Synthetic Mechanism of Polylactic Acid
33. Balla, E., Daniilidis, V., Karlioti, G., Kalamas, T., Stefanidou, M., Bikiaris, N.D., Vlachopoulos, A., Koumentakou, I., and Bikiaris, D.N. (2021). Poly(Lactic Acid): A Versatile Biobased Polymer for the Future with Multifunctional Properties—From Monomer Synthesis, Polymerization Techniques and Molecular Weight Increase to PLA Applications. Polymers, 13.10.3390/polym13111822 ↗
34. Synthesis and Characterization of Poly (Lactic Acid) for Use in Biomedical Field
35. Poly Lactic Acid (PLA) Polymers: From Properties to Biomedical Applications10.1080/00914037.2021.1944140 ↗
36. Polylactic Acid (PLA): Properties, Synthesis, and Biomedical Applications—A Review of the Literature10.1016/j.molstruc.2024.138243 ↗
37. Swetha, T.A., Bora, A., Mohanrasu, K., Balaji, P., Raja, R., Ponnuchamy, K., Muthusamy, G., and Arun, A. (2023). A Comprehensive Review on Polylactic Acid (PLA)—Synthesis, Processing and Application in Food Packaging. Int. J. Biol. Macromol., 234.10.1016/j.ijbiomac.2023.123715 ↗
38. Perspectives of Polylactic Acid from Structure to Applications
39. Environment Friendly, Renewable and Sustainable Poly Lactic Acid (PLA) Based Natural Fiber Reinforced Composites—A Comprehensive Review10.1016/j.jclepro.2021.127483 ↗
40. The Quest for High Glass Transition Temperature Bioplastics10.1039/C8TA00377G ↗
41. Polylactide (PLA)-Based Nanocomposites10.1016/j.progpolymsci.2013.05.014 ↗
42. Polylactic Acid Production from Biotechnological Routes: A Review10.1016/j.ijbiomac.2021.07.074 ↗
43. Current Applications of Poly(Lactic Acid) Composites in Tissue Engineering and Drug Delivery10.1016/j.compositesb.2020.108238 ↗
44. Poly (Lactic Acid)-Based Biomaterials for Orthopaedic Regenerative Engineering10.1016/j.addr.2016.04.015 ↗
45. Poly(Lactic Acid)—Mass Production, Processing, Industrial Applications, and End of Life10.1016/j.addr.2016.03.010 ↗
46. Synthesis, Properties, and Applications of Polylactic Acid-Based Polymers10.1002/pen.26193 ↗
47. Iron and Carbon Monoxide Enhance Coagulation and Attenuate Fibrinolysis by Different Mechanisms10.1097/MBC.0000000000000128 ↗
48. Iron-Enhanced Coagulation Is Attenuated by Chelation A Thrombelastographic and Ultrastructural Analysis10.1097/MBC.0000000000000160 ↗
49. Additive Manufacturing of Biodegradable Iron-Based Particle Reinforced Polylactic Acid Composite Scaffolds for Tissue Engineering10.1016/j.jmatprotec.2020.116952 ↗
50. Core–Shell Fe-Fe3O4 Nanoparticles for Synthesizing PLA Composites with Low Toxicity and High Radiopacity10.1134/S1029959922030079 ↗
51. Microstructural Characterization and Defects Analysis of FDM Based Composite Material (PLA-G-CF)10.1016/j.matpr.2022.04.095 ↗
52. Sonochemical Synthesis of Poly(Lactic Acid) Nanocomposites with ZnO Nanoflowers: Effect of Nanofiller Morphology on Physical Properties10.1021/acsengineeringau.1c00018 ↗
53. Mrozińska, Z., Kudzin, M.H., Ponczek, M.B., Kaczmarek, A., Król, P., Lisiak-Kucińska, A., Żyłła, R., and Walawska, A. (2024). Biochemical Approach to Poly(Lactide)–Copper Composite—Impact on Blood Coagulation Processes. Materials, 17.10.3390/ma17030608 ↗
54. PLLA Scaffold Modification Using Magnetron Sputtering of the Copper Target to Provide Antibacterial Properties
55. Surface Characterization and Properties of Functionalized Nonwoven10.1002/app.26940 ↗
56. Facilitating Complex Thin Film Deposition by Using Magnetron Sputtering: A Review10.1007/s11837-022-05294-0 ↗
57. Investigation of Antibacterial Activity on Cotton Fabrics with Cold Plasma in the Presence of a Magnetic Field10.1002/ppap.200732412 ↗
58. Iron Enhances Generation of Fibrin Fibers in Human Blood: Implications for Pathogenesis of Stroke10.1002/jemt.22047 ↗
59. Oxidation Inhibits Iron-Induced Blood Coagulation10.2174/138945013804806541 ↗
60. Wu, Y., Gao, X., Wu, J., Zhou, T., Nguyen, T.T., and Wang, Y. (2023). Biodegradable Polylactic Acid and Its Composites: Characteristics, Processing, and Sustainable Applications in Sports. Polymers, 15.10.3390/polym15143096 ↗
61. PLA Based Biocomposites for Sustainable Products: A Review
62. (2012). Microbeam Analysis–Selected Instrumental Performance Parameters for the Specification and Checking of Energy-Dispersive X-Ray Spectrometers for Use in Electron Probe Microanalysis (Standard No. ISO 15632:2012).
63. Kaempferol Derivatives Isolated from Lens Culinaris Medik. Reduce DNA Damage Induced by Etoposide in Peripheral Blood Mononuclear Cells10.1039/c9tx00176j ↗
64. Investigation of the Alamar Blue (Resazurin) Fluorescent Dye for the Assessment of Mammalian Cell Cytotoxicity10.1046/j.1432-1327.2000.01606.x ↗
65. Contact Killing of Bacteria on Copper Is Suppressed If Bacterial-Metal Contact Is Prevented and Is Induced on Iron by Copper Ions10.1128/AEM.03608-12 ↗
66. Polylactic Acid (PLA) Melt-Blown Nonwovens with Superior Mechanical Properties10.1021/acssuschemeng.3c00159 ↗
67. Effect of Molecular Weight on the Properties and Structure of Biodegradable Poly-Lactic Acid Melt-Blown Nonwovens10.1007/s10965-024-03927-3 ↗
68. Multifunctional Polylactide Nonwovens with 3D Network of Multiwall Carbon Nanotubes10.1016/j.apsusc.2020.146898 ↗
69. Kudzin, M.H., Mrozińska, Z., Kaczmarek, A., and Lisiak-Kucińska, A. (2020). Deposition of copper on Poly(Lactide) non-woven fabrics by magnetron sputtering-fabrication of new multi-functional, antimicrobial composite materials. Materials, 13.10.3390/ma13183971 ↗
70. Physisorption of Gases, with Special Reference to the Evaluation of Surface Area and Pore Size Distribution (IUPAC Technical Report)10.1515/pac-2014-1117 ↗
71. Pore Characterization of Different Types of Coal from Coal and Gas Outburst Disaster Sites Using Low Temperature Nitrogen Adsorption Approach10.1016/j.ijmst.2017.01.005 ↗
72. Xu, L., Zhang, J., Ding, J., Liu, T., Shi, G., Li, X., Dang, W., Cheng, Y., and Guo, R. (2020). Pore Structure and Fractal Characteristics of Different Shale Lithofacies in the Dalong Formation in the Western Area of the Lower Yangtze Platform. Minerals, 10.10.3390/min10010072 ↗
73. Reporting Physisorption Data for Gas/Solid Systems with Special Reference to the Determination of Surface Area and Porosity (Recommendations 1984)10.1351/pac198557040603 ↗
74. A Review: Fundamental Aspects of Silicate Mesoporous Materials10.3390/ma5122874 ↗
75. Lowell, S., Shields, J.E., Thomas, M.A., and Thommes, M. (2012). Characterization of Porous Solids and Powders: Surface Area, Pore Size and Density, Springer Science & Business Media.
76. Adsorption Surface Area and Porosity10.1149/1.2426447 ↗
77. Systematic Analysis of the Nitrogen Adsorption-Desorption Isotherms Recorded for a Series of Microporous—Mesoporous Amorphous Aluminosilicates Using Classical Methods10.1021/acs.jced.3c00257 ↗
78. Sulfamethoxazole removal and fuel-feedstock biomass production from wastewater in a phyto-Fenton process using duckweed culture10.1016/j.chemosphere.2024.142592 ↗
79. Protective effect of luteolin against oxidative stress-mediated cell injury via enhancing antioxidant systems10.3892/mmr.2024.13244 ↗
80. Disrupting redox homeostasis for tumor therapy based on PDT/chemo/ferroptosis therapeutic hybrid liposomes10.1039/D4RA03361B ↗
81. A Simple Technique for Quantitation of Low Levels of DNA Damage in Individual Cells10.1016/0014-4827(88)90265-0 ↗
82. Lack of cytotoxic and genotoxic effects of mPEG-silane coated iron(III) oxide nanoparticles doped with magnesium despite cellular uptake in cancerous and noncancerous lung cells10.1016/j.tiv.2024.105850 ↗
83. Yue, R., Niu, J., Li, Y., Ke, G., Huang, H., Pei, J., Ding, W., and Yuan, G. (2020). In vitro cytocompatibility, hemocompatibility and antibacterial properties of biodegradable Zn-Cu-Fe alloys for cardiovascular stents applications. Mater. Sci. Eng. C Mater. Biol. Appl., 113.10.1016/j.msec.2020.111007 ↗
84. Application and Development Prospect of Nanoscale Iron Based Metal-Organic Frameworks in Biomedicine10.2147/IJN.S417543 ↗