Characterization of Two Types of Polylactic Acid Coating Loaded with Gentamicin Sulphate Deposed on AZ31 Alloy
Source abstract
Abstract
This paper compares two types of polylactic acid (PLA) coating on AZ31 alloy obtained by dip coating and electrospinning. Both types of coating were loaded with gentamicin sulphate (GS) and the drug-loading efficiency and release were assessed. A higher encapsulation and release efficiency of GS was seen for dip coating (73% and 49.53%, respectively) compared to nanofiber coating (65% and 12.37%, respectively). Furthermore, the antibacterial effect of the samples with and without GS was assessed using Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria, showing that the samples with the drug encapsulated are more resistant to bacteria than the other samples. The electrochemical data reveal a higher stability in the SBF of the surface obtained by dipping than that obtained by electrospinning. The PLA coating shows a porosity of 46% for the sample obtained through dip coating and 32% for nanofibers, which is in accordance with the BET analysis results. Moreover, a higher adhesion strength was obtained for AZ31-PLA-dip (4.99 MPa) than for the AZ31-PLA-nanofibers (1.66 MPa). All samples were structurally, morphologically, and topographically characterized.
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Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Corrosion Behavior and Inhibition · Aluminum Alloys Composites Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of General Chemistry, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania
Department of Pharmaceutical Physics and Informatics, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania
Department of Physical and Colloidal Chemistry, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania
National Institute for Research and Development in Chemistry and Petrochemistry—ICECHIM, Splaiul Independentei No. 202, 6th District, 060021 Bucharest, Romania
Academy of Romanian Scientists, 3 Ilfov Street, 050044 Bucharest, Romania
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