Self-Assembled PHMB Titanium Coating Enables Anti-Fusobacterium nucleatum Strategy
Source abstract
Abstract
Fusobacterium nucleatum (F. nucleatum) is a gram-negative obligate anaerobe bacterium that threatens human periodontal health. It can cause many oral diseases, including periodontitis, gingivitis and peri-implantitis, and even some diseases such as colorectal cancer are related to it. This paper aims to develop a novel and simple surface modification method for anti-Fusobacterium nucleatum on titanium, i.e., the material for implants. In this study, different concentrations (0.0–1.0%) of PHMB were dip-coated on the titanium surface. The surface properties were examined with the aid of Scanning electron microscopy, Energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, and the antibacterial property against F. nucleatum was investigated using colony-forming unit. It was found that the PHMB successfully formed a self-assembled coating on the titanium surface and the PHMB-coated titanium had a strong capability of inhibiting F. nucleatum. Even though differences were found among the several concentrations, PHMB exhibited promising results as a simple coating strategy for dental implants.
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Research context
OpenAlex topics: Dental Implant Techniques and Outcomes · Dental Radiography and Imaging · Oral microbiology and periodontitis research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Dental Materials Science, Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China
Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Monte de Caparica, 2829-511 Almada, Portugal
Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, London NW3 NPF, UK
Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University and Guangdong Research Center for Dental and Cranial Rehabilitation and Material Engineering, Guangzhou 510055, China
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