journal article·2022-02-02Open access

SiC- and Ag-SiC-Doped Hydroxyapatite Coatings Grown Using Magnetron Sputtering on Ti Alloy for Biomedical Application

Iulian Pana, Viorel Braic, Alina Vladescu, Raluca Ion, Anca Constantina Parau, Nicolae Catalin Zoita, Mihaela Dinu, Adrian Emil Kiss, Anisoara Cimpean, Mariana Braic

Coatings· Volume 12· Issue 2

Abstract

SiC- and Ag-SiC-doped hydroxyapatite (HA) coatings were deposited via magnetron sputtering aiming at increased corrosion protection of Ti-10Nb-10Zr-5Ta alloy in simulated body fluid environment and superior mechanical properties compared to plain hydroxyapatite. The coatings had a total thickness of about 350 nm. The X ray diffraction patterns indicate that HA coatings are polycrystalline with a hexagonal structure and the addition of SiC determined the coating amorphization. All coatings presented a lower roughness compared to the Ti alloy and were hydrophilic. Ag-SiC-HA coating presented the best corrosion resistance and tribological parameters. All coatings were biocompatible, as ascertained via indirect cytocompatibility studies conducted on Vero cells.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Metal and Thin Film Mechanics · Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

National Institute of Research and Development for Optoelectronics INOE2000, 409 Atomistilor St., 077125 Magurele, Romania

Materials Science and Composite Materials Centre, Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University, Lenin Avenue 43, 634050 Tomsk, Russia

Department of Biochemistry and Molecular Biology, University of Bucharest, 91–95 Spl. Independentei, 050095 Bucharest, Romania

Funding

Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii

References (81)

Show source-provided references
1. New Ti-alloys and surface modifications to improve the mechanical properties and the biological response to orthopedic and dental implants: A review10.1155/2016/2908570 ↗
2. Surface modification of titanium and titanium alloys: Technologies, developments, and future interests10.1002/adem.201901258 ↗
3. Material science in cervical total disc replacement10.1155/2015/719123 ↗
4. Scaffolds in tissue engineering bone and cartilage10.1016/B978-008045154-1.50021-6 ↗
5. Design and development of three-dimensional scaffolds for tissue engineering10.1205/cherd06196 ↗
6. Recent research and development in titanium alloys for biomedical applications and healthcare goods10.1016/j.stam.2003.09.002 ↗
7. Pignatello, R. (2011). Low modulus titanium alloys for inhibiting bone atrophy. Biomaterials Science and Engineering, IntechOpen.10.5772/1956 ↗
8. Surface and electrochemical characterization of a new ternary titanium based alloy behaviour in electrolytes of varying pH10.1016/j.corsci.2013.07.026 ↗
9. Bonding mechanisms at the interface of ceramic prosthetic materials10.1002/jbm.820050611 ↗
10. Lee, H., Wu, J., Chao, C., Chang, Y., and Du, J. (2020). A study of low Young’s modulus Ti-15Ta-15Nb alloy using TEM analysis. Materials, 13.10.3390/ma13245694 ↗
11. A novel strategy for developing α + β dual-phase titanium alloys with low Young’s modulus and high yield strength10.1016/j.jmst.2020.11.018 ↗
12. XRD and nano-indentation testing of thermo-mechanical processed Ti-29Nb-9Ta-10Zr alloy
13. Characterization of the Ti-10Nb-10Zr-5Ta alloy for biomedical applications. Part 1: Microstructure, mechanical properties, and corrosion resistance10.1007/s11665-013-0517-z ↗
14. Characterization of the Ti-10Nb-10Zr-5Ta alloy for biomedical applications. Part 2: Wettability, tribological performance and biocompatibility10.1007/s11665-013-0738-1 ↗
15. Evaluation of the microstructural, mechanical and anti-corrosive properties of a new ternary Ti-15Zr-5Nb alloy in simulated oral environment10.1002/maco.201307053 ↗
16. Biomechanical behaviours of the bone-implant interface: A review10.1098/rsif.2019.0259 ↗
17. Bonding of bone to apatite-coated implants10.1302/0301-620X.70B1.2828374 ↗
18. Thirumalai, J. (2018). Hydroxyapatite-based coating on biomedical implant. Hydroxyapatite—Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets, IntechOpen.10.5772/intechopen.68820 ↗
19. Mucalo, M. (2015). Hydroxyapatite coatings for metallic implants. Hydroxyapatite (HAp) for Biomedical Applications, Elsevier Ltd.10.1016/B978-1-78242-033-0.00014-6 ↗
20. Charalambous, C.P. (2014). Calcium phosphate ceramics as hard tissue prosthetics. Class. Pap. Orthop., 419–421.10.1007/978-1-4471-5451-8_106 ↗
21. Eliaz, N., and Metoki, N. (2017). Calcium phosphate bioceramics: A review of their history, structure, properties, coating technologies and biomedical applications. Materials, 10.10.3390/ma10040334 ↗
22. Applications of plasma coatings in artificial joints: An overview10.1016/j.vacuum.2003.12.160 ↗
23. Surface properties in titanium with hydroxyapatite coating
24. Hydrothermal preparation and characterization of Zn, Si, Mg, Fe doped hydroxyapatite10.15541/jim20200664 ↗
25. Effect of multi-ions doping on the properties of carbonated hydroxyapatite bioceramic10.1016/j.ceramint.2018.11.003 ↗
26. Substituted hydroxyapatites for bone regeneration: A review of current trends10.1002/jbm.b.33651 ↗
27. Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention10.1016/j.heliyon.2018.e01067 ↗
28. Bratschitsch, G., Puchwein, P., Zollner-Schwetz, I., Sadoghi, P., Radl, R., Leithner, A., and Leitner, L. (2020). Spinal surgery site infection leading to implant loosening is influenced by the number of prior operations. Glob. Spine J., 1–6.10.1177/2192568220957268 ↗
29. A review of the biologic effects of spine implant debris: Fact from fiction10.1016/j.esas.2009.11.005 ↗
30. Insight into biological apatite: Physiochemical properties and preparation approaches10.1155/2013/929748 ↗
31. Sputtered Si and Mg doped hydroxyapatite for biomedical applications10.1088/1748-605X/aa9718 ↗
32. Yang, L., and Mao, Z. (2021). Effect of SiC particle contents and size on the microstructure and dissolution of SiC-hydroxyapatite coatings. Coatings, 11.10.3390/coatings11101166 ↗
33. Structural and physical properties of antibacterial Ag-doped nano-hydroxyapatite synthesized at 100 °C10.1186/1556-276X-6-613 ↗
34. Physics and technology of magnetron sputtering discharges10.1088/1361-6595/abb7bd ↗
35. Production of high silicon-doped hydroxyapatite thin film coatings via magnetron sputtering: Deposition, characterisation, and in vitro biocompatibility10.3390/coatings10020190 ↗
36. Toxicology aspects of topical silver pharmaceuticals10.3109/10408449609012524 ↗
37. In vitro anti-bacterial and biological properties of magnetron co-sputtered silver containing hydroxyapatite coating10.1016/j.biomaterials.2006.07.003 ↗
38. Antibacterial silver10.1155/MBD.1994.467 ↗
39. Neuropathy caused by silver absorption from arthroplasty cement10.1016/S0140-6736(85)92230-5 ↗
40. Effect of the deposition temperature on corrosion resistance and biocompatibility of the hydroxyapatite coatings10.1016/j.apsusc.2015.05.059 ↗
41. Influence of the annealing treatment on the structure, morphology, and corrosion resistance of sputtered Zr-Ti-Si-O coatings used for biomedical applications10.1002/maco.201609200 ↗
42. Influence of the deposition time and temperature on the texture of InN thin films grown by RF-magnetron sputtering
43. Corrosion resistance, mechanical properties and biocompatibility of Hf-containing ZrCN coatings10.1016/j.tsf.2012.12.100 ↗
44. Agarwal, B.K. (1991). X-ray Spectroscopy—An Introduction, Springer. [2nd ed.].10.1007/978-3-540-38668-1 ↗
45. Goldstein, J.I., Newbury, D.E., Echlin, P., Joy, D.C., Lyman, C.E., Lifshin, E., Sawyer, L., and Michael, J.R. (2003). Scanning Electron Microscopy and X-ray Microanalysis, Springer. [3rd ed.].10.1007/978-1-4615-0215-9 ↗
46. International Organization for Standardization (1999). ISO 10993-5 Biological Evaluation of Medical Devices—Part 5: Tests for In Vitro Cytotoxicity, ISO.
47. Mitran, V., Ion, R., Miculescu, F., Necula, M.G., Mocanu, A.C., Stan, G.E., Antoniac, I.V., and Cimpean, A. (2018). Osteoblast cell response to naturally derived calcium phosphate-based materials. Materials, 11.10.3390/ma11071097 ↗
48. Synthesis of silicon-substituted hydroxyapatite using hydrothermal process10.1016/j.bsecv.2019.07.001 ↗
49. Substituted hydroxyapatites for biomedical applications: A review10.1016/j.ceramint.2015.03.316 ↗
50. Bestimmung der Grosse und der Inneren Struktur von Kolloidteilchen Mittels Rontgenstrahlen
51. Mechanical and corrosion resistance of a new nanostructured Ti-Zr-Ta-Nb alloy10.1016/j.jmbbm.2011.05.012 ↗
52. Nanostructured b-phase Ti-39.3Nb-13.3Zr-10.7Ta alloys for biomedical applications: Microstructure benefits on the mechanical and corrosion performances10.1016/j.msec.2012.07.016 ↗
53. Osseointegration of sputtered SiC-added hydroxyapatite for orthopaedic applications10.1016/j.ceramint.2016.03.114 ↗
54. Preparation and characterisation of monoclinic hydroxyapatite and its precipitated carbonate apatite intermediate10.1016/S0142-9612(99)00225-2 ↗
55. Monoclinic hydroxyapatite10.1126/science.180.4090.1055 ↗
56. Elliott, J.C. (1994). Structure and Chemistry of the Apatites and Other Calcium Orthophosphates, Elsevier Science. [1st ed.].
57. Characterization of hydroxyapatite and carbonated apatite by photo acoustic FTIR spectroscopy10.1023/A:1018570213546 ↗
58. Enhancement of the mechanical properties of hydroxyapatite by SiC addition10.1016/j.jmbbm.2014.08.025 ↗
59. Si-rich a-Si 1-x C x thin films by d.c. magnetron co-sputtering of silicon and silicon carbide: Structural and optical properties10.1016/j.apsusc.2012.10.129 ↗
60. Synthesis and characterization of silver doped hydroxyapatite nanocomposite coatings and evaluation of their antibacterial and corrosion resistance properties in simulated body fluid10.1016/j.msec.2016.07.057 ↗
61. Influence of Ag content on the antibacterial properties of SiC doped hydroxyapatite coatings10.1016/j.ceramint.2015.09.143 ↗
62. Nanostructured Si-substituted hydroxyapatite coatings for biomedical applications10.1016/j.tsf.2012.12.113 ↗
63. Synthesis and characterization of silicon-doped hydroxyapatite10.2320/matertrans.MC200808 ↗
64. Mechanical properties and biocompatibility of the sputtered Ti doped hydroxyapatite10.1016/j.jmbbm.2016.06.025 ↗
65. Study on a hydrophobic Ti-doped hydroxyapatite coating for corrosion protection of a titanium based alloy10.1039/C6RA03397K ↗
66. A review of protein adsorption on bioceramics10.1098/rsfs.2012.0012 ↗
67. Rodriguez-Merchan, E.C., Ortega-Andreu, M., and Alonso-Carro, G. (2008). Total hip arthroplasty. Musculoskeletal Aspects of Haemophilia, Blackwell Science.
68. Corrosion behaviour of Ti–10Nb–10Zr–5Ta alloys in artificial saliva solution with fluoride content10.1002/maco.201508382 ↗
69. Defining the transfer coefficient in electrochemistry: An assessment (IUPAC Technical Report)10.1515/pac-2014-5026 ↗
70. Definition of the transfer coefficient in electrochemistry (IUPAC Recommendations 2014)10.1515/pac-2014-5025 ↗
71. Comparison of the corrosion of bulk amorphous steel with conventional steel10.1016/j.corsci.2009.09.016 ↗
72. Electrochemical polarization: I. A theoritical analysis of the shape of polarization curves10.1149/1.2428496 ↗
73. Impedance study on the corrosion of PVD and CVD titanium nitride coatings10.4028/www.scientific.net/MSF.44-45.29 ↗
74. Protective performance of Zr and Cr based silico-oxynitrides used for dental applications by means of potentiodynamic polarization and odd random phase multisine electrochemical impedance spectroscopy10.1016/j.corsci.2016.11.018 ↗
75. Effect of porosity defects on the long-term corrosion behaviour of Fe-based amorphous alloy coated mild steel10.1016/j.corsci.2016.04.021 ↗
76. Influence of the electrolyte’s pH on the properties of electrochemically deposited hydroxyapatite coating on additively manufactured Ti64 alloy10.1038/s41598-017-16985-z ↗
77. Gegener, J. (2013). Introduction of the ratio of the hardness to the reduced elastic modulus for abrasion. Tribology—Fundamentals to Advancements, IntechOpen.10.5772/3427 ↗
78. Effects of Ag-doping on microstructure and mechanical properties of hydroxyapatite films10.4028/www.scientific.net/KEM.277-279.113 ↗
79. The use of silver in self-lubricating coatings for extreme temperatures10.1080/05698198608981698 ↗
80. On the significance of the H/E ratio in wear control: A nanocomposite coating approach to optimised tribological behaviour10.1016/S0043-1648(00)00488-9 ↗
81. The relationship between hardness and scratch adhession10.1016/0040-6090(87)90382-8 ↗