Next-Generation Biomaterials: Advanced Coatings and Smart Interfaces for Implant Technology: A Narrative Review
Source abstract
Abstract
Contemporary advances in bioengineering and materials science have substantially improved the viability of medical implants. The demand for optimized implant technologies has led to the development of advanced coatings that enhance biocompatibility, antimicrobial activity, and durability. Implant manufacturers and surgeons must anticipate both biological and mechanical challenges when implementing devices for patient use. Key areas of concern include infection, corrosion, wear, immune response, and implant rejection; regulatory and economic considerations must also be addressed. Materials science developments are optimizing the integration of established materials such as biometrics, composites, and nanomaterials, while also advancing fabrication-based innovations including plasma functionalization, anodization, and self-assembled monolayers. Emerging smart and stimuli-responsive surface technologies enable controlled drug delivery and real-time implant status communication. These innovations enhance osseointegration, antimicrobial performance, and overall device functionality across orthopedic, dental, and cardiovascular applications. As implant design continues to shift toward personalized, responsive systems, advanced coating technologies are poised to deliver significantly improved long-term clinical outcomes for patients.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Graphene and Nanomaterials Applications · Nanotechnology research and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Department of Orthopaedic Surgery, School of Medicine, Duke University, Durham, NC 27710, USA
References (100+)
Show source-provided references
1. Ratner, B.D., Hoffman, A.S., Schoen, F.J., and Lemons, J.E. (2013). Biomaterials Science, Academic Press. Available online: https://www.sciencedirect.com/book/9780123746269/biomaterials-science.
2. Application of PVD Coatings in Medical Implantology for Enhanced Performance, Biocompatibility, and Quality of Life10.1016/j.heliyon.2024.e35541 ↗
3. Antimicrobial Approaches for Medical Implants Coating to Prevent Implants Associated Infections: Insights to Develop Durable Antimicrobial Implants10.1016/j.apsadv.2023.100532 ↗
4. Recent Developments in Multifunctional Antimicrobial Surfaces and Applications toward Advanced Nitric Oxide-Based Biomaterials10.1021/acsmaterialsau.2c00040 ↗
5. Anti-Fouling Coatings of Poly(Dimethylsiloxane) Devices for Biological and Biomedical Applications10.1007/s40846-015-0029-4 ↗
6. Construction of Nonbiofouling Surfaces by Polymeric Self-Assembled Monolayers10.1021/la034839e ↗
7. Recent Advances in Bone Tissue Engineering Scaffolds10.1016/j.tibtech.2012.07.005 ↗
8. Metallic Implant Biomaterials10.1016/j.mser.2014.10.001 ↗
9. Multifunctional Coatings to Simultaneously Promote Osseointegration and Prevent Infection of Orthopaedic Implants10.1016/j.biomaterials.2016.01.016 ↗
10. Recent Advances in Nanotechnology-Based Functional Coatings for the Built Environment10.1016/j.mtadv.2022.100270 ↗
11. Boopathy, G., Gurusami, K., Vijayakumar, K.R., and Kumar, M.H. (2024). Nanocoatings in Medicine: Revolutionizing Healthcare Through Precision and Potential. Sustainable Approach to Protective Nanocoatings, IGI Global Scientific Publishing.10.4018/979-8-3693-3136-1.ch009 ↗
12. Advancements in 3D Printing Techniques for Biomedical Applications: A Comprehensive Review of Materials Consideration, Post Processing, Applications, and Challenges10.1007/s43939-024-00115-4 ↗
13. Additive Manufacturing in Biomedical: Applications, Challenges, and Prospects10.1016/j.hybadv.2025.100467 ↗
14. Li, J., Fan, H., Li, H., Hua, L., Du, J., He, Y., and Jin, Y. (2025). Recent Advancements in the Surface Modification of Additively Manufactured Metallic Bone Implants. Addit. Manuf. Front., 4.10.1016/j.amf.2025.200195 ↗
15. Advances in Implant Surface Modifications to Improve Osseointegration10.1039/D1MA00675D ↗
16. Surface Coating of Orthopedic Implant to Enhance the Osseointegration and Reduction of Bacterial Colonization: A review10.1186/s40824-022-00269-3 ↗
17. Hussain, M., Askari Rizvi, S.H., Abbas, N., Sajjad, U., Shad, M.R., Badshah, M.A., and Malik, A.I. (2021). Recent Developments in Coatings for Orthopedic Metallic Implants. Coatings, 11.10.3390/coatings11070791 ↗
18. Mosas, K.K.A., Chandrasekar, A.R., Dasan, A., Pakseresht, A., and Galusek, D. (2022). Recent Advancements in Materials and Coatings for Biomedical Implants. Gels, 8.10.3390/gels8050323 ↗
19. Mitra, K., Movva, A.K., Sohn, M.O., Tennyson, J.M., Talaski, G.M., Adams, S.B., and Anastasio, A.T. (2025). Alloy Selection and Manufacturing Technologies for Total Ankle Arthroplasty: A Narrative Review. Materials, 18.10.3390/ma18163770 ↗
20. Ceramics and Ceramic Coatings in Orthopaedics10.1016/j.jeurceramsoc.2015.07.034 ↗
21. Advancements of Bioceramics in Biomedical Applications10.1016/j.nxmate.2025.101010 ↗
22. Evaluation of Highly Carbonated Hydroxyapatite Bioceramic Implant Coatings with Hierarchical Micro-/Nanorod Topography Optimized for Osseointegration10.2147/IJN.S159989 ↗
23. Yang, C.-W., Wang, G.-K., Yang, C.-W., and Wang, G.-K. (2020). Effect of Hydrothermal (Sr)-Hydroxyapatite Coatings on the Corrosion Resistance and Mg2+ Ion Release to Enhance Osteoblastic Cell Responses of AZ91D Alloy. Materials, 13.10.3390/ma13030591 ↗
24. Graziani, G., Boi, M., and Bianchi, M. (2018). A Review on Ionic Substitutions in Hydroxyapatite Thin Films: Towards Complete Biomimetism. Coatings, 8.10.3390/coatings8080269 ↗
25. Si, Sr, Ag Co-Doped Hydroxyapatite/TiO 2 Coating: Enhancement of Its Antibacterial Activity and Osteoinductivity10.1039/C9RA01168D ↗
26. In Vitro Evaluation of Ag Doped Hydroxyapatite Coatings in Acellular Media10.1016/j.ceramint.2019.02.191 ↗
27. Iron Ion-Doped Tricalcium Phosphate Coatings Improve the Properties of Biodegradable Magnesium Alloys for Biomedical Implant Application10.1002/admi.202000531 ↗
28. Ungureanu, E., Vranceanu, D.M., Vladescu, A., Parau, A.C., Tarcolea, M., Cotrut, C.M., Ungureanu, E., Vranceanu, D.M., Vladescu, A., and Parau, A.C. (2021). Effect of Doping Element and Electrolyte’s pH on the Properties of Hydroxyapatite Coatings Obtained by Pulsed Galvanostatic Technique. Coatings, 11.10.3390/coatings11121522 ↗
29. Vranceanu, D.M., Ungureanu, E., Ionescu, I.C., Parau, A.C., Kiss, A.E., Vladescu, A., Cotrut, C.M., Vranceanu, D.M., Ungureanu, E., and Ionescu, I.C. (2022). Electrochemical Surface Biofunctionalization of Titanium through Growth of TiO2 Nanotubes and Deposition of Zn Doped Hydroxyapatite. Coatings, 12.10.3390/coatings12010069 ↗
30. Ungureanu, E., Vladescu, A., Parau, A.C., Mitran, V., Cimpean, A., Tarcolea, M., Vranceanu, D.M., and Cotrut, C.M. (2023). In Vitro Evaluation of Ag- and Sr-Doped Hydroxyapatite Coatings for Medical Applications. Materials, 16.10.3390/ma16155428 ↗
31. Vranceanu, D.M., Ungureanu, E., Ionescu, I.C., Parau, A.C., Pruna, V., Titorencu, I., Badea, M., Gălbău, C.-Ș., Idomir, M., and Dinu, M. (2024). In Vitro Characterization of Hydroxyapatite-Based Coatings Doped with Mg or Zn Electrochemically Deposited on Nanostructured Titanium. Biomimetics, 9.10.3390/biomimetics9040244 ↗
32. Silicon Substitution in the Calcium Phosphate Bioceramics10.1016/j.biomaterials.2007.05.003 ↗
33. Ciobanu, C.S., Predoi, D., Iconaru, S.L., Predoi, M.V., Rokosz, K., Raaen, S., Negrila, C.C., Buton, N., Ghegoiu, L., and Badea, M.L. (2024). Physico-Chemical and Biological Features of Fluorine-Substituted Hydroxyapatite Suspensions. Materials, 17.10.3390/ma17143404 ↗
34. Bioactivity and Biocompatibility of Porous Gradient Bioceramic Coating Prepared via Laser Cladding Process10.1016/j.surfcoat.2021.127800 ↗
35. Bioactivity and Biocompatibility of Hydroxyapatite-Based Bioceramic Coatings on Zirconium by Plasma Electrolytic Oxidation10.1016/j.msec.2016.11.012 ↗
36. Biomedical Applications of Polymer and Ceramic Coatings: A Review of Recent Developments10.1080/00202967.2021.2004744 ↗
37. Flexible Coatings Based on Hydrogel to Enhance the Biointerface of Biomedical Implants10.1016/j.cis.2024.103358 ↗
38. Negut, I., Bita, B., and Groza, A. (2022). Polymeric Coatings and Antimicrobial Peptides as Efficient Systems for Treating Implantable Medical Devices Associated-Infections. Polymers, 14.10.3390/polym14081611 ↗
39. Carbon Materials and Their Metal Composites for Biomedical Applications: A short Review10.1039/D4NR02059F ↗
40. Polymeric Nanocomposites-Based Advanced Coatings for Antimicrobial and Antiviral Applications: A Comprehensive Overview10.1016/j.rsurfi.2025.100497 ↗
41. Silane Coatings of Metallic Biomaterials for Biomedical Implants: A Preliminary Review10.1002/jbm.b.34151 ↗
42. Plasma Surface Functionalization: A Comprehensive Review of Advances in the Quest for Bioinstructive Materials and Interfaces10.1063/5.0130829 ↗
43. Nunes, D., Andrade, S., Ramalho, M.J., Loureiro, J.A., and Pereira, M.C. (2022). Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on In Vivo Findings. Polymers, 14.10.3390/polym14051010 ↗
44. Stetsyshyn, Y., Ohar, H., Budkowski, A., and Lazzara, G. (2025). Molecular Design and Role of the Dynamic Hydrogen Bonds and Hydrophobic Interactions in Temperature-Switchable Polymers: From Understanding to Applications. Polymers, 17.10.3390/polym17111580 ↗
45. Reagent-Free Biomolecule Functionalization of Atmospheric Pressure Plasma-Activated Polymers for Biomedical Applications: Pathways for Covalent Attachment10.1016/j.apsusc.2024.160101 ↗
46. Tan, F., and Al-Rubeai, M. (2019). Customizable Implant-Specific and Tissue-Specific Extracellular Matrix Protein Coatings Fabricated Using Atmospheric Plasma. Front. Bioeng. Biotechnol., 7.10.3389/fbioe.2019.00247 ↗
47. Plasma Treatment in Air at Atmospheric Pressure that Enables Reagent-Free Covalent Immobilization of Biomolecules on Polytetrafluoroethylene (PTFE)10.1016/j.apsusc.2020.146128 ↗
48. Al-Shalawi, F.D., Mohamed Ariff, A.H., Jung, D.-W., Mohd Ariffin, M.K.A., Seng Kim, C.L., Brabazon, D., and Al-Osaimi, M.O. (2023). Biomaterials as Implants in the Orthopedic Field for Regenerative Medicine: Metal versus Synthetic Polymers. Polymers, 15.10.3390/polym15122601 ↗
49. Plasma-based biofunctionalization of vascular implants10.2217/nnm.12.161 ↗
50. Tennyson, J.M., Sohn, M.O., Movva, A.K., Mitra, K., O’Neill, C.N., Anastasio, A.T., and Adams, S.B. (2025). Porous Structures, Surface Modifications, and Smart Technologies for Total Ankle Arthroplasty: A Narrative Review. Bioengineering, 12.10.3390/bioengineering12090955 ↗
51. Stem Cell Fate Dictated Solely by Altered Nanotube Dimension10.1073/pnas.0813200106 ↗
52. Evaluation of Surface Modification Techniques on the Ability of Apatite Formation and Corrosion Behavior in Synthetic Body Fluid: An In Vitro Study10.1016/j.surfin.2020.100866 ↗
53. Mussano, F., Genova, T., Serra, F.G., Carossa, M., Munaron, L., and Carossa, S. (2018). Nano-Pore Size of Alumina Affects Osteoblastic Response. Int. J. Mol. Sci., 19.10.3390/ijms19020528 ↗
54. Anodized Nanostructured 316L Stainless Steel Enhances Osteoblast Functions and Exhibits Anti-Fouling Properties10.1021/acsbiomaterials.2c01072 ↗
55. Nanotubular Surface Modification of Metallic Implants via Electrochemical Anodization Technique10.2147/IJN.S65866 ↗
56. Balcerak-Woźniak, A., Dzwonkowska-Zarzycka, M., and Kabatc-Borcz, J. (2024). A Comprehensive Review of Stimuli-Responsive Smart Polymer Materials—Recent Advances and Future Perspectives. Materials, 17.10.3390/ma17174255 ↗
57. Nanofeature Size and Morphology of Tantalum Oxide Surfaces Control Osteoblast Functions10.1021/acsabm.0c01354 ↗
58. Gardin, C., Ferroni, L., Erdoğan, Y.K., Zanotti, F., De Francesco, F., Trentini, M., Brunello, G., Ercan, B., and Zavan, B. (2021). Nanostructured Modifications of Titanium Surfaces Improve Vascular Regenerative Properties of Exosomes Derived from Mesenchymal Stem Cells: Preliminary In Vitro Results. Nanomaterials, 11.10.3390/nano11123452 ↗
59. Understanding Improved Osteoblast Behavior on Select Nanoporous Anodic Alumina10.2147/IJN.S60346 ↗
60. Surface Modifications of Biomaterials in Different Applied Fields10.1039/D3RA02248J ↗
61. Peptide-Based Self-Assembled Monolayers (SAMs): What Peptides Can Do for SAMs and Vice Versa10.1039/D3CS00921A ↗
62. Thakur, A., Kumar, A., Kaya, S., Marzouki, R., Zhang, F., and Guo, L. (2022). Recent Advancements in Surface Modification, Characterization and Functionalization for Enhancing the Biocompatibility and Corrosion Resistance of Biomedical Implants. Coatings, 12.10.3390/coatings12101459 ↗
63. Precise Surface Engineering: Leveraging Chemical Vapor Deposition for Enhanced Biocompatibility and Durability in Biomedical Implants10.1016/j.heliyon.2024.e37976 ↗
64. Jaafar, A., Hecker, C., Árki, P., and Joseph, Y. (2020). Sol-Gel Derived Hydroxyapatite Coatings for Titanium Implants: A Review. Bioengineering, 7.10.3390/bioengineering7040127 ↗
65. Electrophoretic Deposition of Silica and Its Composite Coatings on Ti-6Al-4V, and Its In Vitro Corrosion Behaviour for Biomedical Applications10.1016/j.msec.2016.10.075 ↗
66. Mechanical Behavior and Corrosion Resistance of Sol-Gel Derived 45S5 Bioactive Glass Coating on Ti6Al4V Synthesized by Electrophoretic Deposition10.1016/j.jmbbm.2022.105352 ↗
67. Abdulghafor, M.A., Mahmood, M.K., Tassery, H., Tardivo, D., Falguiere, A., and Lan, R. (2023). Biomimetic Coatings in Implant Dentistry: A Quick Update. J. Funct. Biomater., 15.10.3390/jfb15010015 ↗
68. Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants10.1002/advs.202207603 ↗
69. Udriște, A.S., Burdușel, A.C., Niculescu, A.-G., Rădulescu, M., and Grumezescu, A.M. (2024). Coatings for Cardiovascular Stents—An Up-to-Date Review. Int. J. Mol. Sci., 25.10.3390/ijms25021078 ↗
70. Słota, D., Jampilek, J., and Sobczak-Kupiec, A. (2024). Hybrid Coatings Based on Polyvinylpyrrolidone/Polyethylene Glycol Enriched with Collagen and Hydroxyapatite: Incubation Studies and Evaluation of Mechanical and Physiochemical Properties. J. Funct. Biomater., 15.10.3390/jfb15030062 ↗
71. Hydroxyapatite Coating on Titanium Alloy TNTZ for Increasing Osseointegration and Reducing Inflammatory Response In Vivo on Rattus norvegicus Wistar Rats10.1016/j.ceramint.2021.02.184 ↗
72. Nanotechnology and Prosthetic Devices: Integrating Biomedicine and Materials Science for Enhanced Performance and Adaptability10.57197/JDR-2024-0019 ↗
73. Recent Advances on Stimuli-Responsive Biopolymer-Based Nanocomposites for Drug Delivery10.1016/j.compositesb.2023.111018 ↗
74. Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery10.1007/s10439-016-1583-9 ↗
75. Wang, Y., and Sun, H. (2021). Polymeric Nanomaterials for Efficient Delivery of Antimicrobial Agents. Pharmaceutics, 13.10.3390/pharmaceutics13122108 ↗
76. 3D Bioactive Composite Scaffolds for Bone Tissue Engineering
77. Smart Scaffolds in Tissue Regeneration10.1093/rb/rby007 ↗
78. A Smart Coating with Integrated Physical Antimicrobial and Strain-Mapping Functionalities for Orthopedic Implants10.1126/sciadv.adg7397 ↗
79. A Review on Biomedical Implant Materials and the Effect of Friction Stir Based Techniques on Their Mechanical and Tribological Properties10.1016/j.jmrt.2022.01.050 ↗
80. Antony Jose, S., Lapierre, Z., Williams, T., Hope, C., Jardin, T., Rodriguez, R., and Menezes, P.L. (2025). Wear- and Corrosion-Resistant Coatings for Extreme Environments: Advances, Challenges, and Future Perspectives. Coatings, 15.10.3390/coatings15080878 ↗
81. Domesticating the Foreign Body Response: Recent Advances and Applications10.1016/j.addr.2019.08.010 ↗
82. DLC Coatings in Biomedical Applications—Review on Current Advantages, Existing Challenges, and Future Directions10.1016/j.surfcoat.2024.131006 ↗
83. Prospects and Challenges of Thin Film Coating Materials and Their Applications10.1016/j.inoche.2025.114117 ↗
84. The Challenges in the Regulatory Approval of Additive-Manufactured Medical Devices: A Quantitative Survey10.1007/s43441-025-00812-z ↗
85. Center for Devices and Radiological Health (2025, September 20). Technical Considerations for Additive Manufactured Medical Devices, Available online: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/technical-considerations-additive-manufactured-medical-devices.
86. Comparison of the Regulatory Requirements for Custom-Made Medical Devices Using 3D Printing in Europe, the United States, and Australia10.1515/bmt-2021-0266 ↗
87. Kadkhodapour, J., Schmauder, S., and Sajadi, F. (2023). Chapter One—Standards for Metal Additive Manufacturing: Quality and Quality Control Procedures. Quality Analysis of Additively Manufactured Metals, Elsevier.
88. Temperature-Responsive Properties of pH-Sensitive Poly(Methacrylic Acid)-Grafted Brush Coatings with Controlled Wettability for Cell Culture10.1039/D4TB02217C ↗
89. Synthesis and Postpolymerization Modification of Thermoresponsive Coatings Based on Pentaerythritol Monomethacrylate: Surface Analysis, Wettability, and Protein Adsorption10.1021/acs.langmuir.5b02285 ↗
90. Cell Sheet Engineering Platforms Integrating Antibacterial and Thermo-Responsive Functionalities: Cu-nanoparticle-Loaded P4VP Brushes for Retinal Cell Sheet Harvesting10.1016/j.cej.2025.162985 ↗
91. ‘Smart’ Polymer Sandwiches From Hydrogel Nanocoatings Attached to Stimuli-Responsive Grafted Brush Coatings: Changing the Cell Behavior10.1002/jbm.b.35631 ↗
92. Highly Efficient Photoswitchable Smart Polymeric Nanovehicle for Gene and Anticancer Drug Delivery in Triple-Negative Breast Cancer10.1021/acsbiomaterials.4c00115 ↗
93. Advances and Applications of Biomimetic Biomaterials for Endogenous Skin Regeneration
94. Nanomaterial Advanced Smart Coatings: Emerging Trends Shaping the Future10.1016/j.apmt.2024.102574 ↗
95. Recent Advances in Surface-Mounted Metal–Organic Framework Thin Film Coatings for Biomaterials and Medical Applications: A Review10.1186/s40824-023-00454-y ↗
96. S53P4 Bioactive Glass Scaffolds Induce BMP Expression and Integrative Bone Formation in a Critical-Sized Diaphysis Defect Treated with a Single-Staged Induced Membrane Technique10.1016/j.actbio.2021.03.035 ↗
97. Recent Advances in Biodegradable Metals for Implant Applications: Exploring In Vivo and In Vitro Responses10.1016/j.rineng.2023.101526 ↗
98. Calais, G.B., Garcia, G.D., de Moura Júnior, C.F., Soares, J.D.M., Lona, L.M.F., Beppu, M.M., Hernandez-Montelongo, J., and Rocha Neto, J.B.M. (2025). Therapeutic Functions of Medical Implants from Various Material Categories with Integrated Biomacromolecular Systems. Front. Bioeng. Biotechnol., 12.10.3389/fbioe.2024.1509397 ↗
99. Surface Engineering of Biodegradable Implants: Emerging Trends in Bioactive Ceramic Coatings and Mechanical Treatments10.1039/D1MA00733E ↗
100. Surface Nanocrystallization and Biomedical Performance of Ti-Ta Laminated Composite Processed by Surface Mechanical Grinding Treatment10.1016/j.apsusc.2023.157051 ↗