journal article·2024-10-28Open access

Novel Antibacterial Resin Coating for Dental Provisional Crowns to Suppress Biofilms and Inhibit Secondary Caries

Ibrahim Ba-Armah, Mohammad Alenizy, Nader Almutairi, Heba Alqarni, Abdullah Alhussein, Radi Masri, Gary D. Hack, Thomas W. Oates, Jirun Sun, Michael D. Weir, Hockin H. K. Xu

Coatings· Volume 14· Issue 11

Abstract

Provisional crowns are often used in dentistry for prolonged periods, but bacterial attachment and dental plaque often lead to gingival inflammation and secondary caries. The aims of this research were to develop a novel resin-based antibacterial provisional crown coating to prevent secondary caries and investigate the physical properties and antibacterial efficacy. The resin-based coating was prepared by addition of triethylene glycoldivinylbenzyl ether and urethane dimethacrylate, with the antibacterial monomer dimethylaminododecyl methacrylate (DMADDM) incorporated at different mass fractions. Surface characteristics including surface roughness and contact angle were assessed. The antibacterial effects were evaluated by 48 h biofilms of Streptococcus mutans (S. mutans) on provisional crowns coated with the resin-based coating. No statistically significant difference was observed in surface roughness across all groups (p > 0.05), showing that adding DMADDM did not have a negative impact on surface roughness. The contact angle results revealed a significant difference in hydrophilicity between different concentrations of DMADDM (p < 0.01), but overall hydrophilicity did not negatively affect the performance of the coating. The incorporation of 5% DMADDM demonstrated a significant antibiofilm effect on S. mutans biofilm CFU with a 4-log reduction compared to controls (p < 0.01). Significant reductions of 4–5 folds were observed in biofilm metabolic activity and lactic acid production (p < 0.01). The findings suggest that the novel coating material could enhance the long-term performance and clinical outcomes of provisional crowns, contributing to better patient oral health.
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Research context

OpenAlex topics: Dental materials and restorations · Dental Erosion and Treatment · Oral microbiology and periodontitis research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Dental Biomedical Sciences PhD Program, Graduate School, University of Maryland, Baltimore, MD 21201, USA

Department of Biomaterials and Regenerative Dental Medicine, University Maryland School of Dentistry, Baltimore, MD 21201, USA

Department of Restorative Dental Science, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia

Department of Restorative Dental Sciences, College of Dentistry, University of Hail, Hail 55475, Saudi Arabia

Department of Conservative Dental Sciences, College of Dentistry, Prince Sattam bin Abdulaziz University, Alkharj 16245, Saudi Arabia

Department of Pediatric Dentistry and Orthodontics Sciences, College of Dentistry, King Khalid University, Abha 61421, Saudi Arabia

Department of Restorative Dental Science, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia

Department of Advanced Oral Sciences and Therapeutics, University Maryland School of Dentistry, Baltimore, MD 21201, USA

The ADA Forsyth Institute, Cambridge, MA 02142, USA

Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA

Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA

Funding

NIH 1R01DE033442-01A1 (Sun, Xu)

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