Comprehensive Evaluation of 45S5 Bioactive Glass Doped with Samarium: From Synthesis and Physical Properties to Biocompatibility and Antimicrobial Activity
Source abstract
Abstract
This paper describes the synthesis and evaluation of samarium-doped 45S5 bioactive glass in various ratios. The bioactive glass samples were prepared using the sol–gel method and subjected to a heat treatment at 700 °C in normal atmosphere. The obtained samples were analyzed by thermogravimetric analysis (TGA) before and after the heat treatment to assess their thermal stability and compositional changes. The bioactivity of the samples was tested in vitro by immersion in simulated body fluid (SBF) at 36.5 ± 0.5 °C (normal human body temperature) and pH 7.4 (the pH of the human blood plasma), for several time periods. During the test, the pH and conductivity of the SBF solutions were monitored to track ion migration. After the in vitro test, the mass loss was evaluated and the formation of hydroxycarbonate apatite (HCA) was analyzed by FTIR spectroscopy. The microstructure of the bioactive glasses was examined using scanning electron microscopy (SEM) and the density of bioactive glass was also determined using Archimedes’ principle. This study also investigated the antimicrobial and anti-biofilm properties of both undoped and samarium-doped 45S5 bioactive glass through qualitative and quantitative assays against a range of microorganisms, including Gram-negative, Gram-positive, and yeast reference strains. The results were compared with literature data on melt-derived bioactive glass to evaluate the effects of Sm doping and the sol–gel synthesis method on bioactive glass performance.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Laser-Ablation Synthesis of Nanoparticles · Dental materials and restorations
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnology, National University of Science and Technology POLITEHNICA Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania
Microsin, Pericle Papahagi st., No 51-63, 032364 Bucharest, Romania
National Research Center for Food Safety, National University of Science and Technology POLITEHNICA Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania
National Center for Micro and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania
Academy of Romanian Scientists, Ilfov Street 3, 050044 Bucharest, Romania
CAMPUS Centre, National University of Science and Technology POLITEHNICA Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Chemical Engineering and Biotechnology, National University of Science and Technology POLITEHNICA Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania
Department of Biochemistry and Molecular Biology, University of Bucharest, 050095 Bucharest, Romania
Department of Botany and Microbiology, Faculty of Biology, University of Bucharest, Intr. Portocalelor No. 1–3, 060101 Bucharest, Romania
Department of Genetics, Faculty of Biology, University of Bucharest, Intr. Portocalelor No. 1–3, 060101 Bucharest, Romania
The Research Institute of the University of Bucharest (ICUB), B.P Hasdeu No. 7, 050095 Bucharest, Romania
Department of Materials Science, Faculty of Materials Science and Engineering, Transilvania University of Brasov, 29 Eroilor Blvd., 500036 Brasov, Romania
National Institute for Research & Development in Chemistry and Petrochemistry-ICECHIM Bucharest, 202 Spl. Independentei, 6th District, 060021 Bucharest, Romania
Funding
Ministry of Research, Innovation, and Digitization
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