A Titanium-Based Superhydrophobic Coating with Enhanced Antibacterial, Anticoagulant, and Anticorrosive Properties for Dental Applications
Source abstract
Abstract
Titanium and its alloys have been widely employed as dental implant materials. However, polymicrobial infection is still one of the most common reasons for implant failure, which has already become a worldwide problem and poses a threat to human health. In this study, a titanium-based (Ti-based) superhydrophobic coating was effectively created by anodization followed by hydrophobic modification of 1H,1H,2H,2H-perfluorodecyltriethoxysilane (FAS), which shows a high water contact angle (WCA) of 159.9 ± 5.8° and a low water sliding angle (WSA) of 2.7 ± 2.2°. The thickness of the anodized samples is from 500 nm to 4 µm as the anodizing voltage increases. The Ti-based superhydrophobic coating demonstrated the existence of Ti, O, C, F, and Si elements, and the corresponding phase compositions are Ti and anatase. The results showed that the Ti-based superhydrophobic coating has good biocompatibility to co-culture with L929 cells for 1, 3, and 5 days. It was also proven that the as-prepared Ti-based superhydrophobic coating has enhanced antibacterial abilities against Staphylococcus aureus (S. aureus) and Porphyromonas gingivalis (P. gingivalis, P.g) after 4, 12, and 24 h. Moreover, the Ti-based superhydrophobic coating can significantly reduce platelet adhesion and activation. In addition, the Ti-based superhydrophobic coating also exhibits a considerable positive shift in the corrosion potential (Ecorr) and a decline of one order of magnitude in the corrosion current density (Jcorr), showing good anticorrosive properties. It was also found that the capsule around the Ti-based superhydrophobic coating was thinner than that of bare Ti after implantation for 7, 15, and 28 days, indicating its good biosafety. Therefore, the as-prepared Ti-based superhydrophobic coating can be a suitable candidate for Ti-based implants in dental applications.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental materials and restorations · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei 230032, China
Funding
National Natural Science Foundation of China · Key Research and Development Program of Anhui Province · College Young and Middle-Aged Teachers Training Action Project of Anhui Education Department · Anhui Province Translational Medical College Research Fund Project · Natural Science Foundation of Anhui Province · Anhui Medical University Basic and Clinical Collaborative Research Enhancement Program · Anhui Medical University · 2022 Disciplinary Construction Project in the School of Dentistry, Anhui Medical University · 2021 Disciplinary Construction Project in the School of Dentistry, Anhui Medical University · Stomatologic Hospital & College of Anhui Medical University
References (73)
Show source-provided references
1. A critical review of multifunctional titanium surfaces: New frontiers for improving osseointegration and host response, avoiding bacteria contamination10.1016/j.actbio.2018.08.013 ↗
2. Review on titanium and titanium based alloys as biomaterials for orthopaedic applications10.1016/j.msec.2019.04.064 ↗
3. Nanostructured Titanium for Biomedical Applications10.1002/adem.200800026 ↗
4. Development and characterization of Ni-free Ti-base shape memory and superelastic alloys10.1016/j.msea.2006.02.054 ↗
5. Structural, physical, chemical, and biological surface characterization of thermomechanically treated Ti-Nb-based alloys for bone implants
6. Ti based biomaterials, the ultimate choice for orthopaedic implants—A review10.1016/j.pmatsci.2008.06.004 ↗
7. Natural products as platforms to overcome antibiotic resistance10.1021/acs.chemrev.7b00283 ↗
8. Antibiotic resistance-the need for global solutions10.1016/S1473-3099(13)70318-9 ↗
9. Supramolecular antibacterial materials for combatting antibiotic resistance10.1002/adma.201805092 ↗
10. New strategies in the development of antimicrobial coatings: The example of increasing usage of silver and silver nanoparticles10.3390/polym3010340 ↗
11. Antibacterial metals and alloys for potential biomedical implants
12. Rao, Q., Weng, L., Zhang, J., Liu, D., Zhang, W., Chen, S., Chen, J., Li, X., Qiu, H., and Cao, Y. (2023). Research progress in superhydrophobic titanium-based implants for antibacterial applications. Coatings, 13.10.3390/coatings13020419 ↗
13. Biomaterials approaches to treating implant-associated osteomyelitis10.1016/j.biomaterials.2015.12.012 ↗
14. Superhydrophobic blood-repellent surfaces10.1002/adma.201705104 ↗
15. Zhang, X., Wan, Y., Ren, B., Wang, H., Yu, M., Liu, A., and Liu, Z. (2020). Preparation of superhydrophobic surface on titanium alloy via micro-milling, anodic oxidation and fluorination. Micromachines, 11.10.3390/mi11030316 ↗
16. Biomaterial-associated thrombosis: Roles of coagulation factors, complement, platelets and leukocytes10.1016/j.biomaterials.2004.01.023 ↗
17. Mystkowska, J., Niemirowicz-Laskowska, K., Łysik, D., Tokajuk, G., Dąbrowski, J., and Bucki, R. (2018). The role of oral cavity biofilm on metallic biomaterial surface destruction–corrosion and friction aspects. Int. J. Mol. Sci., 19.10.3390/ijms19030743 ↗
18. Evaluation of oral microbial corrosion on the surface degradation of dental implant materials10.1002/JPER.18-0110 ↗
19. Microstructural development and corrosion behavior of self-organized TiO2 nanotubes coated on Ti–6Al–7Nb10.1016/j.ceramint.2015.05.025 ↗
20. Spontaneous droplet trampolining on rigid superhydrophobic surfaces10.1038/nature15738 ↗
21. All-organic superhydrophobic coatings with mechanochemical robustness and liquid impalement resistance10.1038/s41563-018-0044-2 ↗
22. Zheng, S., Li, C., Zhang, Y., Xiang, T., Cao, Y., Li, Q., and Chen, Z. (2021). A general strategy towards superhydrophobic self-cleaning and anti-corrosion metallic surfaces: An example with aluminum alloy. Coatings, 11.10.3390/coatings11070788 ↗
23. Mechanically robust hydrophobic bio-based epoxy coatings for anti-corrosion application10.1016/j.surfcoat.2019.02.020 ↗
24. Robust anti-icing performance of a flexible superhydrophobic surface10.1002/adma.201602480 ↗
25. Anti-icing performance of superhydrophobic texture surfaces depending on reference environments10.1002/admi.201700836 ↗
26. Rational construction of highly transparent superhydrophobic coatings based on a non-particle, fluorine-free and water-rich system for versatile oil-water separation10.1016/j.cej.2017.10.006 ↗
27. Development of sol-gel icephobic coatings: Effect of surface roughness and surface energy10.1021/am504348x ↗
28. Preparation and rapid analysis of antibacterial silver, copper and zinc doped sol-gel surfaces10.1016/j.colsurfb.2012.01.035 ↗
29. Facile fabrication of a superhydrophobic titanium surface with mechanical durability by chemical etching10.1039/C5RA15293C ↗
30. Fabrication of superhydrophobic Cu surfaces with tunable regular micro and random nano-scale structures by hybrid laser texture and chemical etching10.1016/j.jmatprotec.2011.02.007 ↗
31. From Cassie state to Gecko state: A facile hydrothermal process for the fabrication of superhydrophobic surfaces with controlled sliding angles on zinc substrates10.1016/j.surfcoat.2014.07.047 ↗
32. Surface modification of titanium implants by silk fibroin/Ag co-functionalized strontium titanate nanotubes for inhibition of bacterial-associated infection and enhancement of in vivo osseointegration10.1016/j.surfcoat.2020.126700 ↗
33. Superhydrophobic fluorinated POSS–PVDF-HFP nanocomposite coating on glass by electrospinning10.1039/c2jm33088a ↗
34. Induction plasma sprayed nano hydroxyapatite coatings on titanium for orthopaedic and dental implants10.1016/j.surfcoat.2010.10.042 ↗
35. Single-step direct fabrication of pillar-on-pore hybrid nanostructures in anodizing aluminum for superior superhydrophobic efficiency10.1021/am201514n ↗
36. Antibacterial ability and angiogenic activity of Cu-Ti-O nanotube arrays10.1016/j.msec.2016.09.077 ↗
37. Targeting pathogenic biofilms: Newly developed superhydrophobic coating favors a host-compatible microbial profile on the titanium surface10.1021/acsami.9b22741 ↗
38. Effect of superhydrophobic surface of titanium on Staphylococcus aureus adhesion10.1155/2011/178921 ↗
39. Antibacterial activity on superhydrophobic titania nanotube arrays10.1016/j.colsurfb.2018.03.019 ↗
40. Improved hemocompatibility and reduced bacterial adhesion on superhydrophobic titania nanoflower surfaces10.1016/j.msec.2020.111503 ↗
41. In vivo blood-repellent performance of a controllable facile-generated superhydrophobic surface10.1021/acsami.0c21058 ↗
42. The study on the anti-corrosion performance of NiTi alloy in human body solution with the fabricating processes of laser irradiation and PDMS modification10.1007/s42235-021-0011-5 ↗
43. Superhemophobic titania nanotube array surfaces for blood contacting medical devices10.1039/C7RA03373G ↗
44. Interaction of blood plasma proteins with superhemophobic titania nanotube surfaces10.1016/j.nano.2019.102046 ↗
45. An easy and environmentally-friendly approach to superamphiphobicity of aluminum surfaces10.1016/j.apsusc.2017.01.091 ↗
46. Surface Modification of Cotton Fabric Using TiO2 Nanoparticles for Self-Cleaning, Oil–Water Separation, Antistain, Anti-Water Absorption, and Antibacterial Properties10.1021/acsomega.9b04067 ↗
47. Hydrophobicity, Adhesion, and Friction Properties of Nanopatterned Polymers and Scale Dependence for Micro- and Nanoelectromechanical Systems10.1021/nl050861b ↗
48. Superhydrophobic materials for biomedical applications10.1016/j.biomaterials.2016.06.050 ↗
49. Controlled synthesis of mussel-inspired Ag nanoparticle coatings with demonstrated in vitro and in vivo antibacterial properties10.1016/j.matdes.2021.109944 ↗
50. Li, Y., Ma, Y., Yu, J., Li, C., Yu, D., Dai, R., Li, Q., and Cao, C.Y. (2023). A dual functional polypeptide with antibacterial and anti-inflammatory properties for the treatment of periodontitis. Int. J. Biol. Macromol., 242.10.1016/j.ijbiomac.2023.124920 ↗
51. Microbiome and microbial biofilm profiles of peri-implantitis: A systematic review10.1902/jop.2017.170123 ↗
52. Covalent immobilization of phytic acid on Mg by alkaline pre-treatment: Corrosion and degradation behavior in phosphate buffered saline10.1016/j.corsci.2013.06.011 ↗
53. Highly efficient and large-scale fabrication of superhydrophobic alumina surface with strong stability based on self-congregated alumina nanowires10.1021/am4057858 ↗
54. Preparation of Si–Mn/biochar composite and discussions about characterizations, advances in application and adsorption mechanisms10.1016/j.chemosphere.2021.130946 ↗
55. Destruction of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) by ball milling10.1021/es400346n ↗
56. New quercetin-coated titanate nanotubes and their radiosensitization effect on human bladder cancer10.1016/j.msec.2020.110662 ↗
57. Preparation, corrosion resistance and hemocompatibility of the superhydrophobic TiO2 coatings on biomedical Ti-6Al-4V alloys10.1016/j.apsusc.2015.04.075 ↗
58. Controllable wettability and adhesion on bioinspired multifunctional TiO2 nanostructure surfaces for liquid manipulation10.1039/C4TA04090B ↗
59. Titania nanotube arrays as interfaces for neural prostheses10.1016/j.msec.2015.01.077 ↗
60. A sprayable superhydrophobic dental protectant with photo-responsive anti-bacterial, acid-resistant, and anti-fouling functions10.1007/s12274-022-4136-6 ↗
61. Antibacterial effects and biocompatibility of titanium surfaces with graded silver incorporation in titania nanotubes10.1016/j.biomaterials.2014.02.005 ↗
62. Neufeld, B.H., and Reynolds, M.M. (2016). Critical nitric oxide concentration for Pseudomonas aeruginosa biofilm reduction on polyurethane substrates. Biointerphases, 11.10.1116/1.4962266 ↗
63. Bacterial retention on superhydrophobic titanium surfaces fabricated by femtosecond laser ablation10.1021/la104607g ↗
64. Copper-based SURMOFs for nitric oxide generation: Hemocompatibility, vascular cell growth, and tissue response10.1021/acsami.8b22731 ↗
65. Hemocompatibility of Superhemophobic Titania Surfaces10.1002/adhm.201600717 ↗
66. A novel electrochemical strategy for improving blood compatibility of titanium-based biomaterials10.1016/j.colsurfb.2010.04.013 ↗
67. Enhanced anticorrosion and tribological properties of Ti6Al4V alloys with Fe3O4/HA coatings10.1016/j.surfcoat.2022.128118 ↗
68. Fabrication of self-cleaning superhydrophobic surface on aluminum alloys with excellent corrosion resistance10.1016/j.surfcoat.2015.07.002 ↗
69. Corrosion behavior of superhydrophobic surfaces: A review10.1016/j.arabjc.2014.03.006 ↗
70. Endothelium-mimicking surface combats thrombosis and biofouling via synergistic long- and short-distance defense strategy10.1002/smll.202100729 ↗
71. Effect of Extreme Wettability on Platelet Adhesion on Metallic Implants: From Superhydrophilicity to Superhydrophobicity10.1021/acsami.6b03644 ↗
72. Foreign body reaction to biomaterials10.1016/j.smim.2007.11.004 ↗
73. Foreign body response to subcutaneous biomaterial implants in a mast cell-deficient Kitw-Sh murine model10.1016/j.actbio.2013.12.056 ↗