Preparation and Antibacterial Properties of PLA-Based Composite Nanofiber Membrane Material Loaded with Cationic Antibacterial Agent by Electrospinning
Source abstract
Abstract
With the continuous application of antibacterial materials, various problems have emerged, such as expensive prices and the potential development of resistance. Cationic antibacterial agents, due to their high solubility, reactivity, and antibacterial properties, are considered as environmentally friendly and cost-effective antibacterial agents. In addition, the electrospinning technique is recognized as a versatile and high-efficiency method to produce nanofibers with multifunctional properties and adjustable structures. In this work, we prepared a series of nanofiber membranes by electrospinning technology using hexadecyl trimethyl ammonium Bromide (CTAB) and 5-Chloro-8-hydroxyquinoline (5-Cl8Q) as antibacterial agents and polylactic acid (PLA) as substrate. The antimicrobial performance of PLA/CTAB/5-Cl8Q was the highest among the prepared materials, which inhabited S. aureus and E. coli up to 99.9% and 95.9%, respectively, and the antibacterial properties were stable. In general, PLA/CTAB/5-Cl8Q has great development potential, and it can be applied to real life as a cost-effective, biodegradable and highly antibacterial material.
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Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Antimicrobial agents and applications · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Nano-Biotechnology, Hebei Key Laboratory of Heavy Metal Deep-Remediation in Water and Resource Reuse, Yanshan University, Qinhuangdao 066004, China
Qinhuangdao Huaheng Bioengineering Co., Ltd., Qinhuangdao 066200, China
Funding
National Natural Science Foundation of China · Natural Science Foundation of Hebei Province · Science and Technology Project of Hebei Education Department · Central Government of China
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