Tunnel Magnetoresistance-Based Sensor for Biomedical Application: Proof-of-Concept
Source abstract
Abstract
The aim of this work was to investigate and prove the possibility of the real-time detection of magnetic nanoparticles (MNPs) distributed in solid material by using a tunnel magnetoresistance-based (TMR) sensor. Following the detection tests of FeCrNbB magnetic nanoparticles distributed in transparent epoxy resin (EPON 812) and measuring the sensor output voltage changes at different particle concentrations, the detection ability of the sensor was demonstrated. For the proposed TMR sensor, we measured a maximum magnetoresistance ratio of about 53% and a sensitivity of 1.24%/Oe. This type of sensor could facilitate a new path of research in the field of magnetic hyperthermia by locating cancer cells.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Characterization and Applications of Magnetic Nanoparticles · Analytical Chemistry and Sensors · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
National Institute of Research and Development for Technical Physics, 700050 Iasi, Romania
Funding
Ministry of Research, Innovation, and Digitization
References (24)
Show source-provided references
1. Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors10.1063/1.3676212 ↗
2. Investigation of contactless detection using a giant magnetoresistance sensor for detecting prostate specific antigen10.1007/s10544-016-0084-9 ↗
3. Ultralow resistance-area product of 0.4 Ω(Μm)2 and high magnetoresistance above 50% in CoFeB/MgO/CoFeB magnetic tunnel junctions10.1063/1.2352046 ↗
4. Magnetic tunnel junction sensors with pTesla sensitivity10.1007/s00542-013-2035-1 ↗
5. Magnetotransport and electronic noise in superparamagnetic magnetic tunnel junctions10.1063/1.5110715 ↗
6. Reconfigurable spintronics wheatstone bridge sensors with offset voltage compensation at wafer level10.1109/TMAG.2019.2896379 ↗
7. Magnetic nanoparticles: Design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications10.1021/cr300068p ↗
8. Magnetically labeled cells can be detected by MR imaging10.1002/jmri.1880070140 ↗
9. Ahmed, M., and Douek, M. (2013). The role of magnetic nanoparticles in the localization and treatment of breast cancer. Biomed Res. Int., 281230.10.1155/2013/281230 ↗
10. Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: Recent advances10.1016/j.mattod.2015.08.022 ↗
11. Quantitative imaging of magnetic nanoparticles by magnetorelaxometry with multiple excitation coil10.1088/0031-9155/59/21/6607 ↗
12. Tomographic imaging using the nonlinear response of magnetic particles10.1038/nature03808 ↗
13. A novel needle-type SV-GMR sensor for biomedical applications10.1109/JSEN.2007.891929 ↗
14. Magnetoresistive detection of magnetic beads flowing at high speed in microfluidic channels10.1109/TMAG.2009.2026287 ↗
15. Detection of 10-nm superparamagnetic iron oxide nanoparticles using exchange-biased GMR sensors in wheatstone bridge10.1109/TMAG.2013.2237889 ↗
16. Magnetic-based biomolecule detection using giant magnetoresistance sensors10.1063/1.4917244 ↗
17. Micro flow cytometry utilizing a magnetic bead-based immunoassay for rapid virus detection10.1016/j.bios.2008.07.019 ↗
18. Human adipose-derived stem cells loaded with drug-coated magnetic nanoparticles for in-vitro tumor cells targeting10.1016/j.msec.2018.10.019 ↗
19. Low TC Fe-Cr-Nb-B glassy submicron powders for hyperthermia applications10.1063/1.4866840 ↗
20. Influence of Cr on the nanoclusters formation and superferromagnetic behavior of Fe-Cr-Nb-B glassy alloys10.1063/1.4916756 ↗
21. Luz Ventosa, T.L.L. (2017). High Performance Magnetic Tunnel Junctions for Magnetic Scanning. [Master’s Thesis, Instituto Superi-or Tecnico].
22. Measurements of laser light attenuation following cryogen spray cooling spurt termination10.1002/lsm.10151 ↗
23. Epoxy resin based tissue substitutes10.1259/0007-1285-50-599-814 ↗
24. Construction and characterization of materials equivalent to the tissues and organs of the human body for radiotherapy10.1016/j.radphyschem.2019.01.013 ↗