Comparison of Mini-Tablets and Pellets as Multiparticulate Drug Delivery Systems for Controlled Drug Release
Source abstract
Abstract
Mini-tablets made into hard capsules or administered using special dosing units, as well as pellets in hard capsules or compressed into tablets, offer the advantages of multiparticulate drug delivery systems and are suitable for controlled drug release using polymer coatings. Four different kinds of solid drug preparations were manufactured and investigated concerning drug release. Inert pellets were coated with the model drug sodium benzoate and, in a second step, with the insoluble polymer ethylcellulose. The coated pellets were compressed into mini-tablets and into normal tablets. Another kind of mini-tablet was compressed from a sodium benzoate compression mixture and finally coated with ethylcellulose. The coating of the tablets was performed using fluidized bed technology. The sodium benzoate release plots of the coated pellets show a lag time and retarded release according first-order kinetics. The mini-tablets and normal tablets compressed from pellets release sodium benzoate according to first-order kinetics as well, but without the lag time due to distinct ethylcellulose layer destruction during tableting. The release is retarded with increasing ethylcellulose layer thickness on directly compressed mini-tablets. The different formulations of coated pellets, mini-tablets, and normal tablets offer a broad choice for variable drug release kinetics depending on the biopharmaceutical and pharmacological requirements.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Drug Solubulity and Delivery Systems · Pharmaceutical studies and practices · Analytical Methods in Pharmaceuticals
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Applied Biosciences and Process Engineering, Anhalt University of Applied Sciences, Strenzfelder Allee 28, 06406 Bernburg, Germany
IMA S.p.A.—ACTIVE Division, Via 1 Maggio 14-16, 40064 Ozzano dell’Emilia, BO, Italy
Funding
The German Research Foundation (Deutsche Forschungsgemeinschaft DFG) · Open Access Publishing Fund of Anhalt University of Applied Sciences
References (44)
Show source-provided references
1. Minitabletting: Improving the compactability of paracetamol powder mixtures10.1016/S0378-5173(98)00206-3 ↗
2. Development of mini-tablets with 1 mm and 2 mm diameter10.1016/j.ijpharm.2011.06.027 ↗
3. Use of interactive mixtures to obtain mini-tablets with high dose homogeneity for paediatric drug delivery10.1016/j.jddst.2016.03.006 ↗
4. Minitablets: Manufacturing, characterization methods, and future opportunities
5. Feasibility of mini-tablets as a flexible drug delivery tool10.1016/j.ijpharm.2017.04.037 ↗
6. Development of matrix type and coated prolonged release minitablets with carbamazepine10.1016/j.ijpharm.2016.06.071 ↗
7. Compressed mini-tablets as a biphasic delivery system10.1016/j.ijpharm.2006.05.063 ↗
8. Mucoadhesive biphasic minitablets of cefuroxime axetil: Formulation development, characterization and in vivo bioavailability study10.1016/j.jddst.2016.07.003 ↗
9. Modifying mini-tablet dissolution with cellulose ethers
10. Design and evaluation of a specific, bi-phase extended release system based on differently coated mini-tablets10.1016/j.ejps.2015.03.010 ↗
11. Combination of film coating and matrix forming effect of Eudragit® copolymers in controlled release minitablets10.1016/j.ejps.2007.05.086 ↗
12. Controlled release delivery: Effect of coating composition on release characteristics of mini-tablets10.1016/0378-5173(89)90284-6 ↗
13. Development of novel flavored Eudragit® E films for feline minitablet coatings10.1016/j.jddst.2016.03.003 ↗
14. Formulation and in vitro / in vivo evaluation of esomeprazole enteric coated minitablets10.1016/j.jddst.2017.03.025 ↗
15. Mucoadhesive amorphous solid dispersions for sustained release of poorly water soluble drugs10.1016/j.ejpb.2016.12.031 ↗
16. Evaluation of a mucoadhesive tablet for ocular use10.1016/S0168-3659(01)00522-3 ↗
17. Characterization and in vivo evaluation of ocular minitablets prepared with different bioadhesive Carbopol-starch components10.1016/j.ejpb.2005.08.003 ↗
18. Development and evaluation of new multiple-unit levodopa sustained-release floating dosage forms10.1016/j.ijpharm.2006.10.018 ↗
19. New levodopa sustained-release floating minitablets coated with insoluble acrylic polymer10.1016/j.ejpb.2007.06.017 ↗
20. In vitro evaluation of two concepts of sustained release floating minitablets according to the model drug used10.1016/S1773-2247(08)50021-9 ↗
21. N-Trimethyl chitosan chloride as absorption enhancer in oral peptide drug delivery. Development and characterization of minitablets and granule formulations10.1016/S0939-6411(03)00152-8 ↗
22. Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complex10.1016/j.ejpb.2010.12.022 ↗
23. Lean production of taste improved lipidic sodium benzoate formulations10.1016/j.ejpb.2014.05.013 ↗
24. Evaluation of the ability of powdered milk to produce minitablets containing paracetamol for paediatric population10.1016/j.cherd.2016.04.014 ↗
25. Influence of the type of enteric coating suspension, coating layer and process conditions on dissolution profile and stability of coated pellets of diclofenac sodium10.1016/j.powtec.2014.09.016 ↗
26. Optimization and scale-up of a fluid bed tangential spray rotogranulation process10.1016/j.ijpharm.2006.11.022 ↗
27. Evaluation of powder, solution and suspension layering for the preparation of enteric coated pellets10.1016/j.ejps.2016.01.018 ↗
28. Preparation and evaluation of duloxetine hydrochloride enteric-coated pellets with different enteric polymers10.1016/j.ajps.2016.08.007 ↗
29. Effects of polyvinylpyrrolidone both as binder and pore-former on the release of sparingly water-soluble topiramate from ethylcellulose coated pellets10.1016/j.ijpharm.2014.02.021 ↗
30. New insight on how to adjust the release profile from coated pellets by varying the molecular weight of ethyl cellulose in coating films10.1016/j.ijpharm.2013.09.016 ↗
31. Formulation and process strategies to minimize coat damage for compaction of coated pellets in a rotary tablet press: A mechanistic view10.1016/j.ijpharm.2015.12.068 ↗
32. Determination of the release mechanism of theophylline from pellets coated with Surelease®—A water dispersion of ethyl cellulose10.1016/j.ijpharm.2017.05.073 ↗
33. Cellulose-polysaccharide film-coating of cyclodextrin based pellets for controlled drug release10.1016/j.jddst.2017.03.031 ↗
34. Comparison of film-coated retarded release pellets manufactured by layering technique or by bed rotor pelletization10.3109/10837450.2013.879883 ↗
35. Development of high drug loaded pellets by Design of Experiment and population balance model calculation10.1016/j.powtec.2013.03.026 ↗
36. Development of modified release multiple unit dosage forms10.1016/j.ejps.2007.05.020 ↗
37. Mini-tablets versus pellets as promising multiparticulate modified release delivery systems for highly soluble drugs10.1016/j.ijpharm.2015.04.021 ↗
38. Determination of coating thickness of minitablets and pellets by dynamic image analysis10.1016/j.ijpharm.2015.08.102 ↗
39. Ganguly, S., Das, P., and Margel, S. (2022). Micro-and Nano-Containers for Smart Applications, Springer Nature.
40. Patel, D.K., Patil, T.V., Ganguly, K., Dutta, S.D., Luthfikasari, R., and Lim, K.T. (2022). Nanorobotics and Nanodiagnostics in Integrative Biology and Biomedicine, Springer International Publishing.
41. Modeling dissolution of sparingly soluble multisized powders10.1021/js960417w ↗
42. Release kinetics of sodium diclofenac from controlled release device
43. Modeling and comparison of release profiles: Effect of the dissolution method10.1016/j.ejps.2017.06.021 ↗
44. Influence of storage conditions on properties of MCC II-based pellets with theophylline-monohydrate10.1016/j.ejpb.2014.06.006 ↗