Nanomaterials for Anti-Infection in Orthopedic Implants: A Review
Source abstract
Abstract
Postoperative implant infection is a severe complication in orthopedic surgery, often leading to implant failure. Current treatment strategies mainly rely on systemic antibiotic therapies, despite contributing to increasing bacterial resistance. In recent years, nanomaterials have gained attention for their potential in anti-infection methods. They exhibit more substantial bactericidal effects and lower drug resistance than conventional antimicrobial agents. Nanomaterials also possess multiple bactericidal mechanisms, such as physico-mechanical interactions. Additionally, they can serve as carriers for localized antimicrobial delivery. This review explores recent applications of nanomaterials with different morphologies in post-orthopedic surgery infections and categorizes their bactericidal mechanisms.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Orthopedic Infections and Treatments · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Orthopedics, Changhai Hospital, Navy Medical University, Shanghai 200433, China
School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Navy Medical University, Shanghai 200003, China
Department of Spine Surgery, Changhai Hospital, Navy Medical University, Shanghai 200433, China
Funding
the Shanghai Science and Technology Innovation Action Plan
References (100+)
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