Polypyrrole/α-Fe2O3 Hybrids for Enhanced Electrochemical Sensing Performance towards Uric Acid
Source abstract
Abstract
Uric acid, a metabolite formed by the oxidation of purines in the human body, plays a crucial role in disease development when its metabolism is altered. Various techniques have been employed for uric acid analysis, with electrochemical sensing emerging as a sensitive, selective, affordable, rapid, and simple approach. In this study, we developed a polymer-based sensor (PPy/α-Fe2O3) for the accurate determination of uric acid levels. The PPy/α-Fe2O3 hybrids were synthesized using an uncomplicated in situ growth technique. Characterization of the samples was performed using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The electrochemical sensing performance towards uric acid was evaluated through cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The obtained results demonstrated that the sensor exhibited excellent sensitivity towards uric acid detection within a wide range of 5–200 μM with a limit of detection (LOD) as low as 1.349 μM. Furthermore, this work elucidated the underlying sensing mechanism and highlighted the pivotal role played by PPy/α-Fe2O3 hybrids in enabling efficient uric acid sensing applications using electrochemical sensors.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Electrochemical sensors and biosensors · Electrochemical Analysis and Applications · Analytical Chemistry and Sensors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Materials Science & Engineering, Henan University of Technology, Zhengzhou 450001, China
Funding
National Natural Science Foundation of China · Natural Science Foundation of Henan University of Technology · Natural Science Project of the Science and Technology Department of Henan Province · Cultivation Programme for Young Backbone Teachers at the Henan University of Technology
References (55)
Show source-provided references
1. Gender-Specific Association between Uric Acid Level and Chronic Kidney Disease in the Elderly Health Checkup Population in China10.1080/0886022X.2019.1591994 ↗
2. Application of Cyclic Voltammetry to Analyse Uric Acid and Reducing Agents in Commercial Milks10.1016/j.foodchem.2019.04.071 ↗
3. Quantification of Uric Acid, Xanthine and Hypoxanthine in Human Serum by HPLC for Pharmacodynamic Studies10.1016/j.jchromb.2006.02.060 ↗
4. A Microfluidic Paper-Based Colorimetric Device for the Visual Detection of Uric Acid in Human Urine Samples10.1039/D1AY01192H ↗
5. A Highly Selective and Sensitive Colorimetric Detection of Uric Acid in Human Serum Based on MoS2-Catalyzed Oxidation TMB10.1007/s00216-018-1524-6 ↗
6. Enzymatic Determination of Uric Acid Using Water-Soluble CuInS/ZnS Quantum Dots as a Fluorescent Probe10.1007/s00604-018-3030-0 ↗
7. Kim, I., Kim, Y.I., Lee, S.W., Jung, H.G., Lee, G., and Yoon, D.S. (2021). Highly Permselective Uric Acid Detection Using Kidney Cell Membrane–Functionalized Enzymatic Biosensors. Biosens. Bioelectron., 190.10.1016/j.bios.2021.113411 ↗
8. Synthesis and Characterization of MgO/ZnO Composite Nanosheets for Biosensor10.1016/j.matchemphys.2015.09.044 ↗
9. A Highly Sensitive Uric Acid Electrochemical Biosensor Based on a Nano-Cube Cuprous Oxide/Ferrocene/Uricase Modified Glassy Carbon Electrode10.1038/s41598-020-67394-8 ↗
10. Bubble-Template-Assisted Synthesis of Hollow Fullerene-like MoS2 Nanocages as a Lithium Ion Battery Anode Material10.1039/C5TA06869J ↗
11. Graphene Aerogel–Metal–Organic Framework-Based Electrochemical Method for Simultaneous Detection of Multiple Heavy-Metal Ions10.1021/acs.analchem.8b03764 ↗
12. A Ratiometric Electrochemical Sensor for Simultaneous Detection of Multiple Heavy Metal Ions Based on Ferrocene-Functionalized Metal-Organic Framework10.1016/j.snb.2020.127756 ↗
13. Bifunctional MOFs-Based Ratiometric Electrochemical Sensor for Multiplex Heavy Metal Ions10.1021/acsami.0c06291 ↗
14. Simultaneous Electrochemical Detection of Cd (II) and Pb (II) Based on L-Cysteine Functionalized Gold Nanoparticles/Metal-Organic Frameworks-Graphene Oxide Nanocomposites10.1016/j.jelechem.2023.117573 ↗
15. Three-Dimensional Graphene/Amino-Functionalized Metal–Organic Framework for Simultaneous Electrochemical Detection of Cd(II), Pb(II), Cu(II), and Hg(II)10.1007/s00216-021-03779-6 ↗
16. Electrochemical Sensing Based MWCNT-Cobalt Tetra Substituted Sorbaamide Phthalocyanine onto the Glassy Carbon Electrode towards the Determination of 2-Amino Phenol: A Voltammetric Study10.1016/j.snb.2019.127078 ↗
17. Chaudhary, A., Khan, M.Q., Khan, R.A., Alsalme, A., Ahmad, K., and Kim, H. (2022). Fabrication of CeO2/GCE for Electrochemical Sensing of Hydroquinone. Biosensors, 12.10.3390/bios12100846 ↗
18. Performance of Metal–Organic Frameworks in the Electrochemical Sensing of Environmental Pollutants10.1039/D0TA08344E ↗
19. Electrochemical Sensing of Tetracycline Based on Au NPs@MoS2/Ch Hybrid Structures10.1016/j.jelechem.2022.116807 ↗
20. Biomass-Derived Porous Graphene for Electrochemical Sensing of Dopamine10.1039/D1RA00735A ↗
21. Alahmadi, N., and El-Said, W.A. (2023). Electrochemical Sensing of Dopamine Using Polypyrrole/Molybdenum Oxide Bilayer-Modified ITO Electrode. Biosensors, 13.10.3390/bios13060578 ↗
22. Employing the Interfacial Barrier of P-rGO/ZnO Microspheres for Improving the Electrochemical Sensing Performance to Dopamine10.1016/j.snb.2020.127757 ↗
23. Microscale Reactor Embedded with Graphene/Hierarchical Gold Nanostructures for Electrochemical Sensing: Application to the Determination of Dopamine10.1007/s00604-019-4059-4 ↗
24. Sonication-Triggered Rolling of Janus Porous Nanomembranes for Electrochemical Sensing of Dopamine and Ascorbic Acid10.1021/acsanm.0c02019 ↗
25. Ni 3 C/Ni Nanochains for Electrochemical Sensing of Glucose10.1021/acsanm.1c01845 ↗
26. Wang, Q., Jia, Q., Hu, P., and Ji, L. (2023). Tunable Non-Enzymatic Glucose Electrochemical Sensing Based on the Ni/Co Bimetallic MOFs. Molecules, 28.10.3390/molecules28155649 ↗
27. ZIF-8 Derived Ni(OH)2 Hollow Nanocages for Non-Enzymatic Glucose Electrochemical Sensing10.1007/s10853-022-07771-y ↗
28. Scalable Synthesis of Ce-MOF Derived CeO/C Hierarchical: Efficient Electrochemical Sensing of Uric Acid as Potential Biomarker in Acute Myeloid Leukaemia Patients10.1016/j.microc.2022.107808 ↗
29. Laser-Induced Graphene from Paper for Non-Enzymatic Uric Acid Electrochemical Sensing in Urine10.1016/j.carbon.2022.06.013 ↗
30. Synthesis of a Three-Layered SiO2@Au Nanoparticle@polyaniline Nanocomposite and Its Application in Simultaneous Electrochemical Detection of Uric Acid and Ascorbic Acid10.1039/C5TB02765A ↗
31. Tunable Graphene Oxide for the Low-Fouling Electrochemical Sensing of Uric Acid in Human Serum10.1039/D3AN00291H ↗
32. ZnO Nanosheets-Decorated ERGO Layers: An Efficient Electrochemical Sensor for Non-Enzymatic Uric Acid Detection10.1109/JSEN.2022.3150088 ↗
33. Cauliflower-Shaped ZnO Nanomaterials for Electrochemical Sensing and Photocatalytic Applications10.1016/j.electacta.2016.10.199 ↗
34. In-Situ Synthesis of ZnO onto Nanoporous Gold Microelectrode for the Electrochemical Sensing of Arsenic(III) in near-Neutral Conditions10.1016/j.snb.2022.133184 ↗
35. Sundar, S., Venkatachalam, G., and Kwon, S. (2018). Biosynthesis of Copper Oxide (CuO) Nanowires and Their Use for the Electrochemical Sensing of Dopamine. Nanomaterials, 8.10.3390/nano8100823 ↗
36. Bifunctional Hexagonal Ni/NiO Nanostructures: Influence of the Core–Shell Phase on Magnetism, Electrochemical Sensing of Serotonin, and Catalytic Reduction of 4-Nitrophenol10.1039/C8NA00342D ↗
37. Preparation and Characterization of Fe2O3 Nanoparticles by Solid-Phase Method and Its Hydrogen Peroxide Sensing Properties10.1021/acssuschemeng.5b01150 ↗
38. Insights into the Fe Oxidation State of Sphere-like Fe2O3 Nanoparticles for Simultaneous Pb2+ and Cu2+ Detection10.1016/j.jallcom.2022.167863 ↗
39. A Facile Preparation of Au—SiO2 Nanocomposite for Simultaneous Electrochemical Detection of Dopamine and Uric Acid10.1016/j.surfin.2018.11.010 ↗
40. Ag Nanoparticles Anchored onto Porous CuO Nanobelts for the Ultrasensitive Electrochemical Detection of Dopamine in Human Serum10.1016/j.snb.2020.128878 ↗
41. Flexible Electrochemical Sensor with Graphene and Gold Nanoparticles to Detect Dopamine and Uric Acid10.1109/JSEN.2021.3122326 ↗
42. Low Potential Determination of Dopamine in the Presence of Ascorbic Acid Using Phenothiazine Dye–Functionalized Graphite Oxide–Modified Electrode10.1007/s11581-023-05233-2 ↗
43. Husain, A., Al-Zahrani, S.A., Al Otaibi, A., Khan, I., Mujahid Ali Khan, M., Alosaimi, A.M., Khan, A., Hussein, M.A., Asiri, A.M., and Jawaid, M. (2021). Fabrication of Reproducible and Selective Ammonia Vapor Sensor-Pellet of Polypyrrole/Cerium Oxide Nanocomposite for Prompt Detection at Room Temperature. Polymers, 13.10.3390/polym13111829 ↗
44. Synthesis and Characterization of Polypyrrole-Coated Iron Oxide Nanoparticles10.1088/2053-1591/abe253 ↗
45. Development and Characterization of Multifunctional Electrospun Ferric Oxide-Gelatin-Glycerol Nanofibrous Mat for Wound Dressing Applications10.1007/s12221-016-6915-8 ↗
46. Novel TPU/Fe2O3 and TPU/Fe2O3/PPy Nanocomposites Synthesized Using Electrospun Nanofibers Investigated for Analyte Sensing Applications at Room Temperature10.1016/j.snb.2019.127384 ↗
47. One-Step Synthesis of Polypyrrole/Fe2O3 Nanocomposite and the Enhanced Response of NO2 at Low Temperature10.1016/j.jcis.2019.10.076 ↗
48. A Flexible Electrochemical Sensor for Paracetamol Based on Porous Honeycomb-like NiCo-MOF Nanosheets10.1007/s12598-023-02349-2 ↗
49. Preparation of Thiolated Calix [8]Arene/AuNPs/MWCNTs Modified Glassy Carbon Electrode and Its Electrocatalytic Oxidation toward Paracetamol10.1016/j.snb.2018.09.012 ↗
50. Comparison of a 2D/3D Imidazole-Based MOF and Its Application as a Non-Enzymatic Electrochemical Sensor for the Detection of Uric Acid10.1039/D2NJ02664C ↗
51. Ni-MOF Nanocomposites Decorated by Au Nanoparticles: An Electrochemical Sensor for Detection of Uric Acid10.1007/s11581-022-04712-2 ↗
52. Fabrication of Electrochemical Biosensor Using Zinc Oxide Nanoflowers for the Detection of Uric Acid10.1007/s12647-022-00598-7 ↗
53. Selective Electrooxidation of Uric Acid in Presence of Ascorbic Acid at a Room Temperature Ionic Liquid/Nickel Hexacyanoferarrate Nanoparticles Composite Electrode10.1016/j.colsurfb.2011.08.011 ↗
54. Holey MoS2-Based Electrochemical Sensors for Simultaneous Dopamine and Uric Acid Detection10.1039/D3AY00573A ↗
55. Cobalt Doped NiFe2O4 on 3D Nickel Foam Substrate for Electrochemical Detection of Uric Acid10.1016/j.surfin.2023.103629 ↗