Silver and Silver Nanoparticles for the Potential Treatment of COVID-19: A Review
Source abstract
Abstract
COVID-19 is an epizootic and life-threatening outbreak affecting millions of people globally. Coronavirus variants have emerged in different locations since their origin. Silver and its compounds, including silver nanoparticles (AgNPs), have been used in the medical field for a long period, especially in surgical treatments. The anti-microbial and anti-viral properties of silver are well documented. These properties depend on the size of the particles, concentration, precursor, method of preparation, and the presence of other benefiting compounds. Several experiments were conducted by researchers worldwide to prove the anti-bacterial and anti-viral properties of silver (Ag) and AgNPs, emphasizing that silver can be introduced to multiple organs in the human body and exhibit the expected antiviral characteristics. In this review article, use of silver nanoparticles to fight the COVID-19 pandemic according with the current information is discussed. The mechanisms involving antiviral activity and toxicity are discussed in detail. This article concludes that strong binding of AgNPs with SARS-CoV-2 virus prevents binding with the host cell, leading to the death of the virus. However, increased cytotoxic effect of the silver compounds at higher concentrations is a matter of concern.
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Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Healthcare and Environmental Waste Management
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Mechanical Engineering, Mar Baselios College of Engineering and Technology, Trivandrum 695015, India
Department of Mechanical Engineering, Amrita Vishwa Vidyapeetham, Amritapuri 690525, India
Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri 690525, India
Department of Mechanical Engineering, College of Engineering, Qassim University, Buraydah 51452, Saudi Arabia
Funding
Amrita Vishwa Vidyapeetham, Amritapuri, India
References (100+)
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