journal article·2023-04-12Open access

A Review of Vertical Graphene and Its Biomedical Applications

Elena Anghel, Bianca Adiaconita, Ioana Demetrescu, Andrei Avram

Coatings· Volume 13· Issue 4

Abstract

This paper explores the synthesis methods and properties of vertically aligned graphene nanosheets (VG) and their applications. VG is obtained using the plasma-enhanced chemical vapor deposition (PECVD) method, and different VG types with other properties can be obtained by changing the process parameters. VG is part of the graphene family; properties such as excellent electrical conductivity, thermal conductivity, chemical stability, and a large, specific surface area make it suitable for biomedical applications. Examples of biomedical applications in which VG is used are biosensors, electrochemical sensors, modified surfaces for bone growth, regeneration, and for antimicrobial effects. First, VG’s properties are reviewed in this review article, and then the most recent progress in its applications and related sciences and technologies are discussed.
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Research context

OpenAlex topics: Graphene research and applications · Graphene and Nanomaterials Applications · Carbon Nanotubes in Composites

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Extreme Light Infrastructure-Nuclear Physics (ELI-NP), Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH), 30 Reactorului Street, 077125 Magurele, Romania

Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania

National Institute for Research and Development in Microtechnologies–IMT Bucharest, 126A Erou Iancu Nicolae Street, 077190 Bucharest, Romania

Academy of Romanian Scientists, 3 Ilfov Street, 030167 Bucharest, Romania

Funding

Romanian Ministry for Research, Innovation, and Digitalization

References (69)

Show source-provided references
1. Production of petal-like graphite sheets by hydrogen arc discharge10.1016/S0008-6223(96)00139-X ↗
2. Morphology and surface engineering of vertical graphene films for dye photodegradation10.1016/j.ceramint.2021.12.145 ↗
3. Emerging energy and environmental applications of vertically-oriented graphenes10.1039/C4CS00352G ↗
4. Morphology Effect of Vertical Graphene on the High Performance of Supercapacitor Electrode10.1021/acsami.5b12652 ↗
5. Tiwari, A. (2017). Graphene Bioelectronics, Elsevier.
6. Preparation, Raman spectroscopy and Morphological analysis of Vertically aligned graphene nanosheets
7. Single Layer Graphene and Vertical Graphene as a Promising Candidate for Electrochemical Biosensors10.37358/RC.20.5.8109 ↗
8. Insights into the Mechanism for Vertical Graphene Growth by Plasma-Enhanced Chemical Vapor Deposition10.1021/acsami.1c21640 ↗
9. Vertical Graphene Growth on SiO Microparticles for Stable Lithium Ion Battery Anodes10.1021/acs.nanolett.7b00906 ↗
10. Yazdi, G.R., Iakimov, T., and Yakimova, R. (2016). Epitaxial Graphene on SiC: A Review of Growth and Characterization. Crystals, 6.10.3390/cryst6050053 ↗
11. Chemical vapor deposition10.1038/s43586-020-00005-y ↗
12. Abbas, Q., Shinde, P.A., Abdelkareem, M.A., Alami, A.H., Mirzaeian, M., Yadav, A., and Olabi, A.G. (2022). Graphene Synthesis Techniques and Environmental Applications. Materials, 15.10.3390/ma15217804 ↗
13. Chen, J., Bo, Z., and Lu, G. (2015). Vertically-Oriented Graphene, Springer International Publishing.10.1007/978-3-319-15302-5 ↗
14. Influence of substrate on nucleation and growth of vertical graphene nanosheets10.1016/j.apsusc.2015.05.038 ↗
15. Fast and non-catalytic growth of transparent and conductive graphene-like carbon films on glass at low temperature10.1088/0022-3727/47/4/045305 ↗
16. Synthesis of few-layer graphene via microwave plasma-enhanced chemical vapor deposition10.1088/0957-4484/19/30/305604 ↗
17. Synthesis and characterization of carbon nanowalls on different substrates by radio frequency plasma enhanced chemical vapor deposition10.1016/j.carbon.2014.02.025 ↗
18. A high density of vertically oriented graphenes for use in electric double layer capacitors10.1016/j.carbon.2012.07.035 ↗
19. Understanding growth of carbon nanowalls at atmospheric pressure using normal glow discharge plasma-enhanced chemical vapor deposition10.1016/j.carbon.2011.01.007 ↗
20. Hiramatsu, M., Kondo, H., and Hori, M. (2013). New Progress on Graphene Research, InTech.
21. Two-dimensional Carbon Nanostructures: Fundamental Properties, Synthesis, Characterization, and Potential Applications10.1063/1.3460809 ↗
22. Freestanding Carbon Nanowalls by Microwave Plasma-enhanced Chemical Vapour Deposition10.1016/j.diamond.2005.11.004 ↗
23. Synthesis of 3-dimensional Porous Graphene Nanosheets Using Electron Cyclotron Resonance Plasma Enhanced Chemical Vapour Deposition10.1039/C5RA09087C ↗
24. Growth of carbon nanowalls on a SiO2 substrate by microwave plasma-enhanced chemical vapor deposition10.1143/JJAP.44.2074 ↗
25. Synthesis of Carbon Nanosheets by Inductively Coupled Radio-frequency Plasma Enhanced Chemical Vapor Deposition10.1016/j.carbon.2004.06.035 ↗
26. Vertical Graphene Gas- and Bio-sensor Via Catalyst-free, Reactive Plasma Reforming of Natural Honey10.1016/j.carbon.2013.04.015 ↗
27. Synthesis of carbon nanosheets and carbon nanotubes by radio frequency plasma enhanced chemical vapor deposition10.1016/j.diamond.2006.05.007 ↗
28. Hishikawa, T., Hiramatsu, M., and Hori, M. (2007, January 13–14). Growth of carbon nanowalls using inductively coupled plasma-enhanced chemical vapor deposition. Proceedings of the 29th International Symposium on Dry Process, Tokyo, Japan.
29. Inductively coupled remote plasma-enhanced chemical vapor deposition (rPE-CVD) as a versatile route for the deposition of graphene micro- and nanostructures10.1016/j.carbon.2017.02.067 ↗
30. Highly Reliable Growth Process of Carbon Nanowalls Using Radical Injection Plasma-enhanced Chemical Vapor Deposition10.1116/1.2938397 ↗
31. Vertical Growth of Carbon Nanowalls Using RF Plasma Enhanced Chemical Vapor Deposition10.1016/j.diamond.2004.10.021 ↗
32. Chabert, P., and Braithwaite, N. (2001). Physics of Radio-Frequency Plasmas, Cambridge University Press.
33. Lieberman, M.A., and Lichtenberg, A.J. (2005). Principles of Plasma Discharges and Materials Processing, Wiley. [2nd ed.].10.1002/0471724254 ↗
34. Plasma techniques for nanostructured carbon materials synthesis. A case study: Carbon nanowall growth by low pressure expanding RF plasma10.1088/0963-0252/19/3/034016 ↗
35. Combined growth of carbon nanotubes and carbon nanowalls by plasma-enhanced chemical vapor deposition10.1016/j.carbon.2007.10.004 ↗
36. Note: Continuous Synthesis of Uniform Vertical Graphene on Cylindrical Surfaces10.1063/1.3624842 ↗
37. Fabrication of Carbon Nanowalls Using Electron Beam Excited Plasma-enhanced Chemical Vapor Deposition10.1016/j.diamond.2008.01.070 ↗
38. Vertical Graphene Nanosheets Synthesized by Thermal Chemical Vapor Deposition and the Field Emission Properties10.1088/0022-3727/49/38/385301 ↗
39. High Packing Density Unidirectional Arrays of Vertically Aligned Graphene with Enhanced Areal Capacitance for High Power Micro-Supercapacitors10.1021/acsnano.7b00553 ↗
40. DC plasma enhanced growth of oriented carbon nanowall films by HFCVD10.1016/j.diamond.2006.11.073 ↗
41. Direct synthesis of multi-layer graphene film on various substrates by microwave plasma at low temperature10.1016/j.tsf.2015.01.011 ↗
42. Process-specific mechanisms of vertically oriented graphene growth in plasmas10.3762/bjnano.8.166 ↗
43. Vertically-oriented graphene nanowalls: Growth and application in Li-ion batteries10.1016/j.diamond.2018.11.007 ↗
44. Synthesis of carbon nanowalls from a single-source metal-organic precursor10.3762/bjnano.9.181 ↗
45. Constructing in-chip micro-supercapacitors of 3D graphene nanowall/ruthenium oxides electrode through silicon-based microfabrication technique10.1016/j.jpowsour.2018.08.099 ↗
46. Effect of the aromatic precursor flow rate on the morphology and properties of carbon nanostructures in plasma enhanced chemical vapor deposition10.1039/C6RA02999J ↗
47. Nanomaterial-Based Prosthetic Limbs for Disability Mobility Assistance: A Review of Recent Advances10.1155/2022/3425297 ↗
48. Al-Jumaili, A., Alancherry, S., Bazaka, K., and Jacob, M. (2017). Review on the Antimicrobial Properties of Carbon Nanostructures. Materials, 10.10.3390/ma10091066 ↗
49. van der Laan; Kumar, S.; Ostrikov, K. Nanostructured Graphene Surfaces Promote Different Stages of Bone Cell Differentiation10.1007/s40820-018-0198-0 ↗
50. Bactericidal vertically aligned graphene networks derived from renewable precursor10.1016/j.cartre.2022.100157 ↗
51. Electrochemical determination of neurotransmitter serotonin using boron/nitrogen co-doped diamond-graphene nanowall-structured particles10.1016/j.jelechem.2022.116938 ↗
52. Recent advances in graphene-based biosensor technology with applications in life sciences10.1186/s12951-018-0400-z ↗
53. Cho, I.-H., Lee, J., Kim, J., Kang, M.S., Paik, J.K., and Ku, S. (2018). Current technologies of electrochemical immunosensors: Perspective on signal amplification. Sensors, 18.10.3390/s18010207 ↗
54. Development of electrochemical DNA biosensors10.1016/j.trac.2012.03.008 ↗
55. Recent advances in electrochemical biosensors based on graphene two-dimensional nanomaterials10.1016/j.bios.2015.07.002 ↗
56. Toward single-DNA electrochemical biosensing by graphene nanowalls10.1021/nn300261t ↗
57. Triplex signal amplification for electrochemical DNA biosensing by coupling probe-gold nanoparticles–graphene modified electrode with enzyme functionalized carbon sphere as tracer10.1016/j.bios.2012.01.006 ↗
58. Direct Growth of Vertically-oriented Graphene for Field-Effect Transistor Biosensor10.1038/srep01696 ↗
59. Flexible electrochemical biosensors based on graphene nanowalls for the real-time measurement of lactate10.1088/1361-6528/aa78bc ↗
60. Graphene nanowalls for high-performance chemotherapeutic drug sensing and anti-fouling properties10.1016/j.snb.2018.02.036 ↗
61. Tincu, B., Burinaru, T., Enciu, A.M., Preda, P., Chiriac, E., Marculescu, C., Avram, M., and Avram, A. (2022). Vertical Graphene-Based Biosensor for Tumor Cell Dielectric Signature Evaluation. Micromachines, 13.10.3390/mi13101671 ↗
62. Electrochemical impedance spectroscopy based microfluidic biosensor for the detection of circulating tumor cells10.1016/j.mtcomm.2022.104016 ↗
63. Stretchable vertical graphene arrays for electronic skin with multifunctional sensing capabilities10.1016/j.cej.2021.134038 ↗
64. Integrated Strain Sensors with Stretchable Vertical Graphene Networks for Non-invasive Physiological Assessment10.1021/acsaelm.1c01097 ↗
65. A label-free electrochemical immunosensor based on a gold–vertical graphene/TiO2 nanotube electrode for CA125 detection in oxidation/reduction dual channels10.1007/s00604-022-05332-3 ↗
66. Li, Y., Liu, X., Li, M., Liu, Q., and Xu, T. (2022). Portable Vertical Graphene@Au-Based Electrochemical Aptasensing Platform for Point-of-Care Testing of Tau Protein in the Blood. Biosensors, 12.10.3390/bios12080564 ↗
67. Boron and nitrogen co-doped vertical graphene electrodes for scalp electroencephalogram recording10.1016/j.carbon.2021.12.056 ↗
68. Electrochemical immunosensors with AuPt-vertical graphene/glassy carbon electrode for alpha-fetoprotein detection based on label-free and sandwich-type strategies10.1016/j.bios.2019.02.045 ↗
69. Development of an Ultra-Sensitive and Flexible Piezoresistive Flow Sensor Using Vertical Graphene Nanosheets10.1007/s40820-020-00446-w ↗