Effect of the Porosity, Roughness, Wettability, and Charge of Micro-Arc Coatings on the Efficiency of Doxorubicin Delivery and Suppression of Cancer Cells
Source abstract
Abstract
Porous calcium phosphate coatings were formed by the micro-arc oxidation method on the surface of titanium for the loading and controlled release of the anticancer drug doxorubicin. The coatings’ morphology and microstructure were examined by scanning electron microscopy. The phase composition was determined with the help of X-ray diffraction analysis. Studies of the hydrophilic properties of the coatings and their zeta potential were carried out. Data on the kinetics of doxorubicin adsorption-desorption were obtained. In addition, the effect of calcium phosphate coatings impregnated with doxorubicin on the viability of the Neuro-2a cell line was revealed. The coating formed at low voltages of 200–250 V contained a greater number of branched communicating pores, and therefore they were able to adsorb a greater amount of doxorubicin. The surface charge also contributes to the process of the adsorption-desorption of doxorubicin, but this effect is not fully understood and further studies are required to identify it.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Metal and Thin Film Mechanics · Thallium and Germanium Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Laboratory of Physics of Nanostructured Biocomposites, Institute of Strength Physics and Materials Science of SB RAS, 634055 Tomsk, Russia
Research School of High-Energy Physics, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia
Laboratory of Physical Chemistry of Ultrafine Materials, Institute of Strength Physics and Materials Science of SB RAS, 634055 Tomsk, Russia
REC Nanotechnology, School of Engineering Far Eastern Federal University, 690091 Vladivostok, Russia
References (47)
Show source-provided references
1. Albumin loaded PEO coatings on Ti—Potential as drug eluting systems10.1016/j.surfcoat.2015.10.045 ↗
2. Trends in biomedical engineering: Focus on smart bio-materials and drug delivery
3. Mechanism of cell integration on biomaterial implant surfaces in the presence of bacterial contamination10.1002/jbm.a.35502 ↗
4. Antibacterial potential associated with drug-delivery built TiO2 nanotubes in biomedical implants10.1186/s13568-019-0777-6 ↗
5. Recent advances on smart TiO2 nanotube platforms for sustainable drug delivery applications10.2147/IJN.S117498 ↗
6. Porous TiO2 surface formed on nickel–titanium alloy by plasma electrolytic oxidation: A prospective polymer-free reservoir for drug eluting stent applications10.1002/jbm.b.32872 ↗
7. Surface modification of valve metals using plasma electrolytic oxidation for antibacterial applications: A review10.1002/jbm.a.36259 ↗
8. Formation mechanism and adhesive strength of a hydroxyapatite/TiO2 composite coating on a titanium surface prepared by micro-arc oxidation10.1016/j.apsusc.2015.11.086 ↗
9. Biocompatible hydrophilic brushite coatings on AZX310 and AM50 alloys for orthopedic implants
10. Influence of process parameters on electrolytic plasma discharging behavior and aluminum oxide coating microstructure10.1016/j.surfcoat.2010.08.059 ↗
11. Gentamicin coating of plasma chemical oxidized titanium alloy prevents implant-related osteomyelitis in rats10.1016/j.biomaterials.2016.05.039 ↗
12. Sealing the pores of PEO coating with Mg-Al layered double hydroxide: Enhanced corrosion resistance, cytocompatibility and drug delivery ability
13. Husak, Y., Solodovnyk, O., Yanovska, A., Kozik, Y., Liubchak, I., Ivchenko, V., Mishchenko, O., Zinchenko, Y., Kuznetsov, V., and Pogorielov, M. (2018). Degradation and in vivo response of hydroxyapatite-coated Mg alloy. Coatings, 8.10.3390/coatings8110375 ↗
14. Improving the corrosion resistance of ZEK100 magnesium alloy by combining high-pressure torsion technology with hydroxyapatite coating10.1016/j.matdes.2019.107933 ↗
15. A Review of hydroxyapatite-based coating techniques: Sol-gel and electrochemical depositions on biocompatible metals10.1016/j.jmbbm.2015.11.031 ↗
16. Multiphasic calcium orthophosphate (CaPO4) bioceramics and their biomedical applications10.1016/j.ceramint.2016.01.062 ↗
17. A review on the dissolution models of calcium apatites10.1016/S0960-8974(02)00004-9 ↗
18. Setting behavior and drug release from brushite bone cement prepared with granulated hydroxyapatite and β-tricalcium phosphate10.4191/kcers.2019.56.1.06 ↗
19. Corrosion resistance and antibacterial effects of hydroxyapatite coating induced by polyacrylic acid and gentamicin sulfate on magnesium alloy10.1007/s11706-019-0448-1 ↗
20. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries10.3322/caac.21492 ↗
21. Doxorubicin-loaded human serum albumin nanoparticles overcome transporter-mediated drug resistance
22. Evaluation of patients’ adherrence to chemotherapy for breast cancer
23. Factors influencing adherence to cancer treatment in older adults with cancer: A systematic review10.1093/annonc/mdt433 ↗
24. Biodegradable PLGA implants containing doxorubicin-loaded chitosan nanoparticles for treatment of breast tumor-bearing mice10.1016/j.ijbiomac.2019.06.055 ↗
25. Doxorubicin-loaded electrospun poly(L-lactic acid)/mesoporous silica nanoparticles composite nanofibers for potential postsurgical cancer treatment10.1039/c3tb20636j ↗
26. Surface modification of doxorubicin-loaded nanoparticles based on polydopamine with pH-sensitive property for tumor targeting therapy10.1080/10717544.2018.1440447 ↗
27. In vitro and in vivo efficacy of doxorubicin loaded biodegradable semi-interpenetrating hydrogel implants of poly (acrylic acid)/gelatin for post surgical tumor treatment10.1088/1748-6041/8/4/045004 ↗
28. Development and physicochemical characterization of doxorubicin-encapsulated hydroxyapatite–polyvinyl alcohol nanocomposite for repair of osteosarcoma-affected bone tissues10.1016/j.crci.2018.10.005 ↗
29. Modification of titanium surface via Ag-, Sr- and Si-containing micro-arc calcium phosphate coating
30. Sedelnikova, M.B., Komarova, E.G., Sharkeev, Y.P., Tolkacheva, T.V., Sheikin, V.V., Egorkin, V.S., Mashtalyar, D.V., Kazakbaeva, A.A., and Schmidt, J. (2018). Characterization of the Micro-Arc Coatings Containing β-Tricalcium Phosphate Particles on Mg-0.8Ca Alloy. Metals, 8.10.3390/met8040238 ↗
31. Zn-, Cu- or Ag-incorporated micro-arc coatings on titanium alloys: Properties and behavior in synthetic biological media10.1016/j.surfcoat.2019.04.021 ↗
32. ASTM E1382–97 (2015). Standard Test Methods for Determining Average Grain Size Using Semiautomatic and Automatic Image Analysis, ASTM International.
33. (1995). BS DD ENV 1071-5 Advanced Technical Ceramics—Methods of Test for Ceramic Coatings Part 5: Determination of Porosity, British Standards Institution (BSI).
34. Structure and properties of micro-arc calcium phosphate coatings on pure titanium and Ti–40Nb alloy10.1016/S1003-6326(17)60014-1 ↗
35. Analysis for determining surface energy uncertainty by the Owens-Wendt method10.1016/j.ijadhadh.2008.09.008 ↗
36. Sittampalam, G.S., and Grossman, A. (2004). Cell viability assays assay guidance manual. Assay Guidance Manual, Eli Lilly & Company and the National Center for Advancing Translational Sciences.
37. Pilot in vitro study of the parameters of artificial niche for osteogenic differentiation of human stromal stem cell pool10.1007/s10517-011-1184-4 ↗
38. Development of calcium phosphate coatings with regulated porous structure as drug carrier systems10.1088/1742-6596/1281/1/012037 ↗
39. Surface charge and the effect of excess calcium ions on the hydroxyapatite surface10.1016/j.biomaterials.2005.04.060 ↗
40. A Self-setting monetite (CaHPO4) cement for skeletal repair
41. Osteoconductivity of hydrophilic microstructured titanium implants with phosphate ion chemistry10.1016/j.actbio.2009.02.026 ↗
42. The surface energy of various biomaterials coated with adhesion molecules used in cell culture10.1016/j.colsurfb.2006.11.021 ↗
43. Electrically functionalized hydroxyapatite and calcium phosphate surfaces to enhance immobilization and proliferation of osteoblasts in vitro and modulate osteogenesis in vivo10.1007/978-3-642-03900-3_70 ↗
44. The role of surface wettability and surface charge of electrosprayed nanoapatites on the behaviour of osteoblasts10.1016/j.actbio.2009.08.012 ↗
45. Electrostatic inter-actions as a predictor for osteoblast attachment to biomate-rials
46. Manipulation of selective cell adhesion and growth by surface charges of electrically polarized hydroxyapatite10.1002/1097-4636(20011205)57:3<366::AID-JBM1179>3.0.CO;2-X ↗
47. (2002). Masato Ueshima, Satoshi Tanaka, Satoshi Nakamura, Kimihiro Yamashita, Manipulation of bacterial adhesion and proliferation by surface charges of electrically polarized hydroxyapatite. J. Biomed. Mater. Res., 60, 578–584.10.1002/jbm.10113 ↗