Hydrogel Nanoparticle as a Functional Coating Layer in Biosensing, Tissue Engineering, and Drug Delivery
Source abstract
Abstract
The development of functional coating materials has resulted in many breakthroughs in the discovery of energy, environmental, and biomedical applications. Responsive polymeric hydrogels are an example of smart coating materials due to their stimuli-responsive characteristics upon changes in their local environment. This review focuses on the introduction of hydrogel nanoparticles and their applications in functional layers as responsive coating materials. Hydrogels are explained by the composition of cross-links and monomers used for preparation. In particular, an important class of responsive hydrogels, that is, nanosized hydrogel particles (nanogels), are described for thee synthesis, modification, and application in assembly of functional coating layers. Finally, nanogel functional layers for biological applications will be discussed with recent advances in biosensing, tissue engineering, and drug delivery.
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Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · Supramolecular Self-Assembly in Materials · Polymer Surface Interaction Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
R&D Center, Scholar Foxtrot Co., Ltd., Seoul 04626, Korea
Concordia International School Shanghai, Shanghai 201206, China
Cornerstone Collegiate Academy of Seoul, Seoul 06779, Korea
Branksome Hall Asia, Seoqwipo 63644, Korea
Phil-Mount Christian Academy, Erdenheim, PA 19038, USA
References (100+)
Show source-provided references
1. Hydrogels for biomedical applications10.1016/S0169-409X(01)00239-3 ↗
2. Tumor marker-responsive behavior of gels prepared by biomolecular imprinting10.1073/pnas.0506786103 ↗
3. Novel crosslinking methods to design hydrogels10.1016/S0169-409X(01)00240-X ↗
4. Hydrogels—Very versatile materials
5. Hydrogels for tissue engineering: Scaffold design variables and applications10.1016/S0142-9612(03)00340-5 ↗
6. DeRossi, D., Kajiwara, K., Osada, Y., and Yamauchi, A. (1991). Polymer Gels. Fundamentals and Biomedical Applications, Plenum Press.10.1007/978-1-4684-5892-3 ↗
7. Photoswitchable microlens arrays10.1002/anie.200461538 ↗
8. Adaptive liquid microlenses activated by stimuli-responsive hydrogels10.1038/nature05024 ↗
9. Colloidal hydrogel microlenses10.1002/adma.200305675 ↗
10. Hydrogel microparticles as dynamically tunable microlenses10.1021/ja047274x ↗
11. Nanogel nanosecond photonic crystal optical switching10.1021/ja037118a ↗
12. Functional hydrogel structures for autonomous flow control inside microfluidic channels10.1038/35007047 ↗
13. Controlled microfluidic interfaces10.1038/nature04163 ↗
14. Responsive biomimetic hydrogel valve for microfluidics10.1063/1.1367010 ↗
15. Flow control with hydrogels10.1016/j.addr.2003.08.013 ↗
16. Fast pH- and ionic strength-responsive hydrogels in microchannels10.1021/la001709m ↗
17. Application of sensitive hydrogels in flow control10.1002/1099-1581(200008/12)11:8/12<496::AID-PAT996>3.0.CO;2-7 ↗
18. Polymer gels with engineered environmentally responsive surface patterns10.1038/30205 ↗
19. Write-read-erase molecular-switching system trapped in a polymer hydrogel matrix10.1002/adfm.200400274 ↗
20. A novel photoderinable reactive polymer coating and its use for microfabrication of hydrogel elements10.1002/adma.200400101 ↗
21. Polymerized colloidal crystal hydrogel films as intelligent chemical sensing materials10.1038/39834 ↗
22. Molecular recognition in a supramolecular hydrogel to afford a semi-wet sensor chip10.1021/ja045962a ↗
23. Glucose-sensitive holographic sensors for monitoring bacterial growth10.1021/ac049334n ↗
24. Intelligent polymerized crystalline colloidal arrays: Novel chemical sensor materials10.1021/ac970853i ↗
25. Entropic trapping of macromolecules by mesoscopic periodic voids in a polymer hydrogel10.1038/16426 ↗
26. Photonic crystal chemical sensors: pH and ionic strength10.1021/ja002017n ↗
27. Photonic crystal aqueous metal cation sensing materials10.1021/ac026328n ↗
28. Reversible adsorption of calcium ions by imprinted temperature sensitive gels10.1063/1.1339265 ↗
29. Thermomorphic rhodium(I) and palladium(0) catalysts10.1021/ja980136l ↗
30. Poly(N-isopropylacrylamide) soluble polymer supports in catalysis and synthesis10.1021/ma980836a ↗
31. Catalytic properties of enzymes modified with temperature-responsive polymer-chains10.1002/macp.1995.021960216 ↗
32. Photoresponsive polymer-enzyme switches10.1073/pnas.262427799 ↗
33. Electrically erodible polymer gel for controlled release of drugs10.1038/354291a0 ↗
34. Hydrogels: Swelling, drug loading, and release10.1023/A:1015887213431 ↗
35. Biodegradable block copolymers as injectable drug-delivery systems10.1038/42218 ↗
36. Hydrogels and drug delivery10.1016/S1359-0294(97)80103-3 ↗
37. Drug delivery and targeting
38. Temperature modulated protein release from pH/temperature-sensitive hydrogels10.1016/S0142-9612(98)00197-5 ↗
39. Pulsatile drug release control using hydrogels10.1016/S0169-409X(01)00243-5 ↗
40. Thermally modulated insulin release from microgel thin films10.1021/bm049750h ↗
41. Doxorubicin uptake and release from microgel thin films10.1021/bm049455x ↗
42. Matrix metalloprotease triggered delivery of cancer chemotherapeutics from hydrogel matrixes10.1021/bc0501303 ↗
43. Magnetically responsive polymeric microparticles for oral delivery of protein drugs10.1007/s11095-005-9444-5 ↗
44. Small-scale systems for in vivo drug delivery10.1038/nbt876 ↗
45. A novel strategy for encapsulation and release of proteins: Hydrogels and microgels with acid-labile acetal cross-linkers10.1021/ja026925r ↗
46. Hydrogels: From controlled release to pH-responsive drug delivery10.1016/S1359-6446(02)02255-9 ↗
47. Environment-sensitive hydrogels for drug delivery10.1016/S0169-409X(01)00203-4 ↗
48. In vitro studies of the interaction of poly(NIPAm/MAA) nanoparticles with proteins and cells10.1163/156856200743616 ↗
49. Folate-mediated cell targeting and cytotoxicity using thermoresponsive microgels10.1021/ja0474143 ↗
50. Polymeric systems for controlled drug release10.1021/cr940351u ↗
51. A synthetic mimic of the secretory granule for drug delivery10.1038/28822 ↗
52. Electrochemically induced disintegration of layer-by-layer-assembled thin films composed of 2-iminobiotin-labeled poly(ethyleneimine) and avidin10.1021/bm060819q ↗
53. Ligand-functionalized core/shell microgels with permselective shells10.1002/anie.200461090 ↗
54. Smart hydrogels for bioseparation10.1023/A:1008050124949 ↗
55. Smart latexes for bioseparation10.1023/A:1008055211667 ↗
56. The ingrowth of new bone tissue and initial mechanical properties of a degrading polymeric composite scaffold10.1089/ten.1995.1.41 ↗
57. A photolabile hydrogel for guided three-dimensional cell growth and migration10.1038/nmat1092 ↗
58. Cell-responsive synthetic hydrogels10.1002/adma.200304621 ↗
59. Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics10.1073/pnas.0737381100 ↗
60. Galactosylated poly(N-isopropylacrylamide) hydrogel submicrometer particles for specific cellular uptake within hepatocytes10.1006/jcis.2002.8427 ↗
61. Review: Hydrogels for cell immobilization10.1002/(SICI)1097-0290(19960520)50:4<357::AID-BIT2>3.0.CO;2-K ↗
62. Controlled growth factor release from synthetic extracellular matrices10.1038/35050141 ↗
63. Label-free biosensing with hydrogel microlenses10.1002/anie.200503102 ↗
64. Bioresponsive hydrogel microlenses10.1021/ja0519076 ↗
65. Photonic crystal carbohydrate sensors: Low ionic strength sugar sensing10.1021/ja021037h ↗
66. High ionic strength glucose-sensing photonic crystal10.1021/ac030021m ↗
67. Acetylcholinesterase-based organophosphate nerve agent sensing photonic crystal10.1021/ac048562e ↗
68. Fast responsive crystalline colloidal array photonic crystal glucose sensors10.1021/ac060643i ↗
69. Antigen responsive hydrogels based on polymerizable antibody fab’ fragment10.1002/mabi.200390039 ↗
70. Biomolecule-sensitive hydrogels10.1016/S0169-409X(01)00241-1 ↗
71. A reversibly antigen-responsive hydrogel10.1038/21619 ↗
72. Totally synthetic polymer gels responding to external glucose concentration: Their preparation and application to on-off regulation of insulin release10.1021/ja982975d ↗
73. Dynamic behavior of glucose-responsive poly(methacrylic acid-G-ethylene glycol) hydrogels10.1021/ma970117g ↗
74. A general photonic crystal sensing motif: Creatinine in bodily fluids10.1021/ja038187s ↗
75. Controlled association of amphiphilic polymers in water: Thermosensitive nanoparticles formed by self-assembly of hydrophobically modified pullulans and poly(N-isopropylacrylamides)10.1021/ma991798d ↗
76. Thermally and photochemically triggered self-assembly of peptide hydrogels10.1021/ja011535a ↗
77. Complexation between polyoxyethylene and poly(methacrylic acid). The importance of the molar mass of polyoxyethylene10.1016/0014-3057(94)90003-5 ↗
78. Equilibrium swelling of poly(methacrylic acid-G-ethylene glycol) hydrogels effect of swelling medium and synthesis conditions10.1016/S0168-3659(97)00186-7 ↗
79. NMR studies on water and polymer diffusion in dextran gels. Influence of potassium ions on microstructure formation and gelation mechanism10.1002/mrm.1910350511 ↗
80. Alginates10.1016/0144-8617(88)90001-X ↗
81. Protein release from alginate matrixes10.1016/S0169-409X(97)00124-5 ↗
82. Optimization of microencapsulation parameters: Semipermeable microcapsules as a bioartificial pancreas10.1002/bit.260270207 ↗
83. Solution properties of poly(N-isopropylacrylamide)10.1080/10601326808051910 ↗
84. Collapse of gels and the critical endpoint10.1103/PhysRevLett.40.820 ↗
85. Kinetics of swelling of gels10.1063/1.437602 ↗
86. Phase transition in ionic gels10.1103/PhysRevLett.45.1636 ↗
87. Collapse of gels in an electric-field10.1126/science.218.4571.467 ↗
88. Critical kinetics of volume phase transition of gels10.1103/PhysRevLett.55.2455 ↗
89. Kinetics of phase transition in polymer gels10.1016/0378-4371(86)90230-X ↗
90. Kinetics of discontinuous volume-phase transition of gels10.1063/1.455115 ↗
91. Phase transition of N-substituted acrylamide gels10.1021/ma00224a023 ↗
92. Kinetics of swelling and shrinking of gels10.1063/1.458148 ↗
93. Phase-transition in polymer gels induced by visible-light10.1038/346345a0 ↗
94. Laser light scattering study of the phase transition of poly(N-isopropylacrylamide) in water. 1. Single Chain10.1021/ma00128a056 ↗
95. Temperature-sensitive aqueous microgels10.1016/S0001-8686(99)00023-8 ↗
96. Temperature-jump investigations of the kinetics of hydrogel nanoparticle volume phase transitions10.1021/ja016610w ↗
97. Photothermal patterning of microgel/gold nanoparticle composite colloidal crystals10.1021/ja027431x ↗
98. Microlens formation in microgel/gold colloid composite materials via photothermal patterning10.1021/ja034076h ↗
99. Investigations into the deswelling dynamics and thermodynamics of thermoresponsive microgel composite films10.1021/la034390p ↗
100. Photoinduced phase transitions in poly(N-isopropylacrylamide) microgels10.1021/cm049650i ↗