An In Vitro Study of the Antifungal Efficacy of Zinc Oxide Nanoparticles against Saccharomyces cerevisiae
Source abstract
Abstract
Zinc oxide nanoparticles (ZnO NPs) are widely used in biomedical applications due to their antimicrobial and antioxidant properties. The objective of the present study was to determine the antifungal activity of ZnO NPs against the yeast Saccharomyces cerevisiae. The turbidity test results showed a significant (p < 0.05) dose-dependent growth inhibitory effect of ZnO NPs on S. cerevisiae as the growth inhibition increased from 7.04 ± 0.64 to 70.30 ± 3.19% as the concentration of ZnO NPs increased from 5 to 150 μg/mL. The scanning microscopy images evidenced the morphological alterations such as regional invagination, pitting, cracks, wrinkles, and cell wall rupture in the yeast cells treated with ZnO NPs. In addition, the FTIR spectrum revealed the possible involvement of hydroxyl, alkene, amides, carbonyl, and phosphate groups from polysaccharides, polypeptides, phospholipids, and ergosterol of the yeast cells wall for binding of ZnO NPs on the cell surface. The present study has demonstrated the antifungal activity of ZnO NPs on S. cerevisiae through growth inhibition and the morphological damages resulting from the treatment of ZnO NPs.
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Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Nanocomposite Films for Food Packaging · Quantum Dots Synthesis And Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar 31900, Malaysia
Life Science Division, Faculty of Health and Life Sciences, INTI International University, Nilai 71800, Malaysia
Viyen Biotech LLP, Coimbatore 641031, India
Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar 31900, Malaysia
Centre for Materials Engineering and Regenerative Medicine, Bharath Institute of Higher Education and Research, Chennai 600126, India
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, USCI University, Kuala Lumpur 56000, Malaysia
Centre for Photonics and Advanced Materials Research (CPAMR), Universiti Tunku Abdul Rahman (UTAR), Sungai Long Campus, Kajang 43000, Malaysia
Faculty of Medicine, Bioscience and Nursing, MAHSA University, Kuala Lumpur 42610, Malaysia
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh 30450, Malaysia
Faculty of Dentistry, AIMST University, Bedong 08100, Malaysia
Funding
Universiti Tunku Abdul Rahman Research Fund · Ministry of Education, Malaysia
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