Innovative Coatings of Metallic Alloys Used as Bioactive Surfaces in Implantology: A Review
Source abstract
Abstract
Metallic implants are widely used in the field of implantology, but there are still problems leading to implant failures due to weak osseointegration, low mechanical strength for the implant, inadequate antibacterial properties, and low patient satisfaction. Implant failure can be caused by bacterial infections and poor osteointegration. To improve the implant functionalization, many researchers focus on surface modifications to prepare the proper physical and chemical conditions able to increase biocompatibility and osteointegration between implant and bone. Improving the antibacterial performance is also a key factor to avoid the inflammation in the human body. This paper is a brief review for the types of coatings used to increase osseointegration and biocompatibility for the successful use of metal alloys in the field of implantology.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty · Titanium Alloys Microstructure and Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of General Chemistry, Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania
Clinical Department of Orthopedics and Traumatology II, Clinical Emergency Hospital, Calea Floreasca 8, 014461 Bucharest, Romania
References (100+)
Show source-provided references
1. Scaffolds for bone regeneration: State of the art10.2174/1381612822666160203114902 ↗
2. Biofunctionalization of metallic implants by calcium phosphate coatings
3. Understanding and controlling the bone-implant interface10.1016/S0142-9612(99)00160-X ↗
4. Review of metallic biomaterials in dental applications10.4103/jpbs.JPBS_88_20 ↗
5. Bio-functionalization of biomedical metals10.1016/j.msec.2016.06.067 ↗
6. Dehghanghadikolaei, A., and Fotovvati, B. (2019). Coating techniques for functional enhancement of metal implants for bone replacement: A review. Materials, 12.10.3390/ma12111795 ↗
7. Biocompatibility assessments for medical devices—evolving regulatory considerations10.1080/17434440.2017.1280392 ↗
8. Morphological studies on machined implants of commercially pure titanium and titanium alloy (Ti6Al4V) in the rabbit10.1002/jbm.b.31404 ↗
9. Bioactive coating as a surface modification technique for biocompatible metallic implants: A review10.1080/21870764.2019.1669861 ↗
10. Enhanced wear and corrosion in modular tapers in total hip replacement is associated with the contact area and surface topography10.1002/jor.22461 ↗
11. Omar, M.A., Baharudin, B.-H., and Sulaiman, S. (2016, January 28–29). Stent manufacturing using cobalt chromium molybdenum (CoCrMo) by selective laser melting technology. Proceedings of the 3rd Advanced Materials Conference, Kedah, Malaysia.10.1063/1.5010539 ↗
12. Recent metallic materials for biomedical applications10.1007/s11661-002-0109-2 ↗
13. Metallic implant biomaterials10.1016/j.mser.2014.10.001 ↗
14. Laughlin, D.E., and Hono, K. (2014). Magnetic properties of metals and alloys. Physical Metallurgy, Elsevier. [5th ed.].
15. Niinomi, M. (2010). New-generation metallic biomaterials. Metals for Biomedical Devices, Woodhead Publishing.10.1533/9781845699246 ↗
16. Titanium-tissue interface reaction and its control with surface treatment10.3389/fbioe.2019.00170 ↗
17. Activity of vancomycin release from bioinspired coatings of hydroxyapatite or TiO 2 nanotubes10.1016/j.ijpharm.2016.11.062 ↗
18. Mesoporous titanium dioxide coating for metallic implants10.1002/jbm.b.31925 ↗
19. Beig, B., Liaqat, U., Niazi, M., Douna, I., Zahoor, M., and Niazi, M. (2020). Current challenges and innovative developments in hydroxyapatite-based coatings on metallic materials for bone implantation: A review. Coatings, 10.10.3390/coatings10121249 ↗
20. Multilayered coating of titanium implants promotes coupled osteogenesis and angiogenesis in vitro and in vivo10.1016/j.actbio.2018.04.043 ↗
21. Polymeric hybrid coatings on Ti50%Zr alloy
22. Multifunctional polymer coatings for titanium implants10.1016/j.msec.2018.08.065 ↗
23. Antibacterial coating of implants: Are we missing something?10.1302/2046-3758.85.BJR-2018-0316 ↗
24. Amengual-Peñafiel, L., Brañes-Aroca, M., Marchesani-Carrasco, F., Jara-Sepúlveda, M.C., Parada-Pozas, L., and Cartes-Velásquez, R. (2019). Coupling between osseointegration and mechanotransduction to maintain foreign body equilibrium in the long-term: A comprehensive overview. J. Clin. Med., 8.10.3390/jcm8020139 ↗
25. Bioactive titanium implant surfaces with bacterial inhibition and osteoblast function enhancement properties10.1177/039139880803100905 ↗
26. Novel strategy for mechanically tunable and bioactive metal implants10.1016/j.biomaterials.2014.10.027 ↗
27. Role of implants surface modification in osseointegration: A systematic review10.1002/jbm.a.36829 ↗
28. Design of dental implants at materials level: An overview10.1002/jbm.a.36931 ↗
29. Eliaz, N., and Metoki, N. (2017). Calcium phosphate bioceramics: A review of their history, structure, properties, coating technologies and biomedical applications. Materials, 10.10.3390/ma10040334 ↗
30. Calcium orthophosphates10.4161/biom.18790 ↗
31. Calcium phosphates in oral biology and medicine10.1159/000419232 ↗
32. A mineralogical perspective on the apatite in bone10.1016/j.msec.2005.01.008 ↗
33. Calcium orthophosphates in nature, biology and medicine10.3390/ma2020399 ↗
34. Hydroxyapatite and their use as coatings in dental implants: A review10.1615/CritRevBiomedEng.v28.i56.10 ↗
35. Phase formation and evolution in the silicon substituted tricalcium phosphate/apatite system10.1016/j.biomaterials.2004.09.005 ↗
36. Jarcho, M. (1981). Calcium phosphate ceramics as hard tissue prosthetics. Clin. Orthop. Relat. Res., 259–278.10.1097/00003086-198106000-00037 ↗
37. Tissue, cellular and subcellular events at a bone-ceramic hydroxylapatite interface
38. Review paper: Behavior of ceramic biomaterials derived from tricalcium phosphate in physiological condition10.1177/0885328208096798 ↗
39. Calcium phosphate-based osteoinductive materials10.1021/cr800427g ↗
40. Surface chemistry and biological responses to synthetic octacalcium phosphate
41. Development of a titanium alloy suitable for an optimized coating with hydroxyapatite10.1016/0142-9612(95)92123-N ↗
42. Sol–gel hydroxyapatite coatings on stainless steel substrates10.1016/S0142-9612(01)00157-0 ↗
43. Fixation of hip prostheses by hydroxyapatite ceramic coatings10.1302/0301-620X.73B5.1654336 ↗
44. International Organization for Standardization (2018). Implants for Surgery—Hydroxyapatite—Part 2: Thermally Sprayed Coatings of Hydroxyapatite, International Organization for Standardization. Available online: https://www.iso.org/standard/64617.html.
45. Osteoconductive coatings for total joint arthroplasty10.1097/00003086-200202000-00007 ↗
46. Surface treatments of titanium dental implants for rapid osseointegration10.1016/j.dental.2006.06.025 ↗
47. Material fundamentals and clinical performance of plasma-sprayed hydroxyapatite coatings: A review10.1002/jbm.1056 ↗
48. Enhance stability and in vitro cell response to a bioinspired coating on zr alloy with increasing chitosan content10.1016/S1672-6529(16)60411-0 ↗
49. Degradation of hydroxylapatite, fluorapatite, and fluorhydroxyapatite coatings of dental implants in dogs10.1002/(SICI)1097-4636(1999)48:3<224::AID-JBM5>3.0.CO;2-A ↗
50. Student research award in the undergraduate, Master candidate category, or health science degree candidate category, 17th annual meeting of the society for biomaterials, scottsdale, AZ may 1-5,1991. Characterization of the interface in the plasma-sprayed HA coating/Ti-6Al-4V implant system10.1002/jbm.820251004 ↗
51. Adhesion of thermally sprayed hydroxyapatite–bond-coat systems measured by a novel peel test10.1023/A:1008822309486 ↗
52. Plasma sprayed hydroxyapatite coatings on titanium substrates Part 1: Mechanical properties and residual stress levels10.1016/S0142-9612(98)00103-3 ↗
53. Bond strength determination of hydroxyapatite coatings on Ti-6Al-4V substrates using the LAser Shock Adhesion Test (LASAT)10.1002/jbm.a.32907 ↗
54. HA coating on Mg alloys for biomedical applications: A review10.1016/j.jma.2020.05.003 ↗
55. Hydroxyapatite—Past, present, and future in bone regeneration10.4137/BTRI.S36138 ↗
56. Nanopatterned titanium implants accelerate bone formation in vivo10.1021/acsami.0c10273 ↗
57. Hemocompatibility of titanium oxide films10.1016/S0142-9612(03)00046-2 ↗
58. Surface modification of titanium, titanium alloys, and related materials for biomedical applications10.1016/j.mser.2004.11.001 ↗
59. Effect of mechanical surface pretreatment on metal ion release10.1016/S0142-9612(99)00200-8 ↗
60. Polymorphic phase transition among the titania crystal structures using a solution-based approach: From precursor chemistry to nucleation process10.1039/C4NR01657B ↗
61. Titanium-protein interaction: Changes with oxide layer thickness10.1177/088532829100600107 ↗
62. In vitro investigation of blood compatibility of Ti with oxide layers of rutile structure10.1177/088532829400800406 ↗
63. In vivo study of Ti–O thin film fabricated by PIII10.1016/S0257-8972(02)00087-7 ↗
64. Corrosion, antibacterial activity and haemocompatibility of TiO 2 nanotubes as a function of their annealing temperature10.1016/j.corsci.2015.11.021 ↗
65. Electrolytic deposition of titania films as interference coatings on biomedical implants: Microstructure, chemistry and nano-mechanical properties10.1016/j.tsf.2005.09.068 ↗
66. Wear behaviour of NiTi shape memory alloy after oxygen-PIII treatment10.1016/j.surfcoat.2005.11.070 ↗
67. Characterization and corrosion studies of titania-coated NiTi prepared by sol–gel technique and steam crystallization10.1016/j.apsusc.2007.01.121 ↗
68. Preparation of different forms of titanium oxide on titanium surface: Effects on apatite deposition10.1002/jbm.a.30171 ↗
69. Unusual aerobic and anaerobic bacteria associated with prosthetic joint infections10.1097/01.blo.0000229317.43631.81 ↗
70. Structural dependence of apatite formation on titania gels in a simulated body fluid10.1002/jbm.a.10414 ↗
71. Enhancing the performance of titanium surface via elaboration of a nanostructure and a bioactive coating
72. Nanopores and nanotubes ceramic oxides elaborated on titanium alloy with zirconium by changing anodization potentials10.1016/j.ceramint.2018.01.137 ↗
73. Bioactivation of titanium surfaces using coatings of TiO2 nanotubes rapidly pre-loaded with synthetic hydroxyapatite10.1016/j.actbio.2009.02.032 ↗
74. Vardaki, M., Pantazi, A., Demetrescu, I., and Enachescu, M. (2021). Assessing the functional properties of TiZr nanotubular structures for biomedical applications, through nano-scratch tests and adhesion force maps. Molecules, 26.10.3390/molecules26040900 ↗
75. Post treatments effect on TiZr nanostructures fabricated via anodizing10.1016/j.jmrt.2019.09.049 ↗
76. Understanding surface and interface properties of modified Ti50Zr with nanotubes10.1016/j.apsusc.2019.144661 ↗
77. Synthesizing and comparing HA–TiO2 and HA–ZrO2 nanocomposite coatings on 316 stainless steel10.1007/s42452-019-0168-2 ↗
78. In vitro electrochemical behavior of sol-gel derived hydroxyapatite/graphene oxide composite coatings on 316L SS for biomedical applications10.1002/slct.202003368 ↗
79. Antibacterial composite hybrid coatings of veterinary medical implants10.1016/j.msec.2020.110968 ↗
80. Thermal sprayed composite coatings for biomedical implants: A brief review10.52687/2582-1474/213 ↗
81. Zirconia as a ceramic biomaterial10.1016/S0142-9612(98)00010-6 ↗
82. Magnetron sputtering of tin protective coatings for medical applications10.1016/0924-0136(95)01856-5 ↗
83. The role of hydrated silica, titania, and alumina in inducing apatite on implants10.1002/jbm.820280103 ↗
84. Artificial heart valves: Improved blood compatibility by PECVD a-SiC:H coating10.1111/j.1525-1594.1990.tb02967.x ↗
85. Design, characterization and testing of Ti-based multicomponent coatings for load-bearing medical applications10.1016/j.biomaterials.2004.09.010 ↗
86. Antimicrobial activity of the surface coatings on TiAlZr implant biomaterial10.1016/j.jbiosc.2011.07.022 ↗
87. Bond strength of plasma-sprayed hydroxyapatite/Ti composite coatings10.1016/S0142-9612(99)00255-0 ↗
88. Prodana, M., Nistor, C.-E., Stoian, A.B., Ionita, D., and Burnei, C. (2020). Dual nanofibrous bioactive coatings on TiZr implants. Coatings, 10.10.3390/coatings10060526 ↗
89. A new complex ceramic coating with carbon nanotubes, hydroxyapatite and TiO2 nanotubes on Ti surface for biomedical applications10.1016/j.ceramint.2015.01.060 ↗
90. Comparing three different composites carbon nanotubes/HA on titanium alloys substrate10.1080/1536383X.2013.874344 ↗
91. Poly(methyl metacrylate) nanocomposites for two-piece CAD/CAM solution as an alternative to monolithic removable prosthesis10.37358/MP.18.4.5091 ↗
92. ZrO2/hydroxyapatite coating on titanium by electrolytic deposition10.1007/s10856-008-3603-2 ↗
93. Hydroxyapatite–diamondlike carbon nanocomposite films10.1016/j.msec.2005.01.023 ↗
94. Characterization of functionally graded hydroxyapatite/titanium composite coatings plasma-sprayed on Ti alloys10.1002/jbm.b.30465 ↗
95. Apatite/titanium composite coatings on titanium or titanium alloy by RF plasma-spraying process10.1016/S0040-6090(00)01654-0 ↗
96. Synthesis and characterization of TiN, TiAIN and TiN/TiAIN biocompatible coatings10.1016/j.surfcoat.2005.02.140 ↗
97. Corrosion of an active antibacterial nanostructured coating on titanium10.37358/RC.18.5.6271 ↗
98. Electrochemical and antibacterial properties of an electrodeposited hydroxiapatite bionic film on titanium
99. Antibacterial coating systems10.1016/j.injury.2006.04.013 ↗
100. Antibacterial coatings on titanium implants10.1002/jbm.b.31463 ↗