journal article·2019-04-26Open access

In-Vivo Corrosion Characterization and Assessment of Absorbable Metal Implants

Mokhamad Fakhrul Ulum, Wahyu Caesarendra, Reza Alavi, Hendra Hermawan

Coatings· Volume 9· Issue 5

Abstract

Absorbable metals have been introduced as materials to fabricate temporary medical implants. Iron, magnesium and zinc have been considered as major base elements of such metals. The metallurgical characterization and in-vitro corrosion assessment of these metals have been covered by the new ASTM standards F3160 and F3268. However, the in-vivo corrosion characterization and assessment of absorbable metal implants are not yet well established. The corrosion of metals in the in-vivo environment leads to metal ion release and corrosion product formation that may cause excessive toxicity. The aim of this work is to introduce the techniques to assess absorbable metal implants and their in-vivo corrosion behavior. This contains the existing approaches, e.g., implant retrieval and histological analysis, ultrasonography and radiography, and the new techniques for real-time in-vivo corrosion monitoring.
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Research context

OpenAlex topics: Magnesium Alloys: Properties and Applications · Orthopaedic implants and arthroplasty · Corrosion Behavior and Inhibition

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor 16680, Indonesia

Faculty of Integrated Technologies, University of Brunei Darussalam, Gadong BE1410, Brunei Darussalam, & Department of Mechanical Engineering, Diponegoro University, Semarang 50275, Indonesia

Department of Mining, Metallurgical and Materials Engineering & CHU de Québec Research Center, Laval University, Quebec City, QC G1V 0A6, Canada

Funding

Natural Sciences and Engineering Research Council of Canada

References (87)

Show source-provided references
1. (2016). ASTM F3160-16 Standard Guide for Metallurgical Characterization of Absorbable Metallic Materials for Medical Implants, ASTM International.
2. Biodegradable metals10.1016/j.mser.2014.01.001 ↗
3. Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibility and surface modifications10.1016/j.msec.2016.06.020 ↗
4. Updates on the research and development of absorbable metals for biomedical applications10.1007/s40204-018-0091-4 ↗
5. Corrosion resistance of a self-healing micro-arc oxidation/polymethyltrimethoxysilane composite coating on magnesium alloy AZ3110.1016/j.corsci.2017.01.025 ↗
6. In vitro corrosion properties and cytocompatibility of Fe-Ga alloys as potential biodegradable metallic materials10.1016/j.msec.2016.09.086 ↗
7. Sustained safety and clinical performance of a drug-eluting absorbable metal scaffold up to 24 months: Pooled outcomes of biosolve-ii and biosolve-iii10.4244/EIJ-D-17-00254 ↗
8. Bioabsorbable metal screws in traumatology: A promising innovation10.1016/j.tcr.2017.01.012 ↗
9. Design of magnesium alloys with controllable degradation for biomedical implants: From bulk to surface10.1016/j.actbio.2016.09.005 ↗
10. Zinc-based alloys for degradable vascular stent applications10.1016/j.actbio.2018.03.005 ↗
11. Advances in fe-based biodegradable metallic materials10.1039/C6RA20594A ↗
12. Comparative mechanical and corrosion studies on magnesium, zinc and iron alloys as biodegradable metals
13. Biodegradable Fe-based alloys for use in osteosynthesis: Outcome of an in vivo study after 52 weeks10.1016/j.actbio.2014.04.007 ↗
14. In vitro and in vivo corrosion properties of new iron–manganese alloys designed for cardiovascular applications10.1002/jbm.b.33234 ↗
15. Long-term in vivo corrosion behavior, biocompatibility and bioresorption mechanism of a bioresorbable nitrided iron scaffold10.1016/j.actbio.2017.03.020 ↗
16. Enhanced corrosion resistance and cytocompatibility of biodegradable mg alloys by introduction of Mg(OH)2 particles into poly (l-lactic acid) coating10.1038/srep41796 ↗
17. A novel biodegradable and biologically functional arginine-based poly (ester urea urethane) coating for Mg–Zn–Y–Nd alloy: Enhancement in corrosion resistance and biocompatibility10.1039/C6TB03147A ↗
18. Microstructure, mechanical and corrosion properties of biodegradable powder metallurgical Fe-2 wt% x (x= Pd, Ag and C) alloys10.1016/j.matchemphys.2016.06.087 ↗
19. Novel biodegradable Fe-Mn-Cs alloy with superior mechanical and corrosion properties10.1016/j.matlet.2016.10.037 ↗
20. Novel antibacterial biodegradable Fe-Mn-Ag alloys produced by mechanical alloying10.1016/j.msec.2018.03.005 ↗
21. Long-term in vitro degradation behaviour of fe and Fe/Mg2Si composites for biodegradable implant applications10.1039/C8RA00404H ↗
22. Design and characterization of a novel biocorrodible iron-based drug-eluting coronary scaffold10.1016/j.matdes.2015.11.045 ↗
23. In vitro studies on silver implanted pure iron by metal vapor vacuum arc technique10.1016/j.colsurfb.2016.01.065 ↗
24. Controlling the degradation kinetics of porous iron by poly (lactic-co-glycolic acid) infiltration for use as temporary medical implants10.1038/srep11194 ↗
25. Tailoring the electrochemical degradation of iron protected with polypyrrole films for biodegradable cardiovascular stents10.1016/j.electacta.2017.05.172 ↗
26. Effects of scandium addition on biocompatibility of biodegradable Mg–1.5Zn–0.6Zr alloy10.1016/j.matlet.2017.12.097 ↗
27. Assessing the degradation performance of ultrahigh-purity magnesium in vitro and in vivo10.1016/j.corsci.2014.09.008 ↗
28. In vivo and in vitro assessment of the biocompatibility and degradation of high-purity Mg anastomotic staples10.1177/0885328217692948 ↗
29. Influence of Ca and Zn on the microstructure and corrosion of biodegradable Mg–Ca–Zn alloys10.1016/j.corsci.2015.01.027 ↗
30. A promising biodegradable magnesium alloy suitable for clinical vascular stent application10.1038/srep46343 ↗
31. In vitro and in vivo biocompatibility and corrosion behaviour of a bioabsorbable magnesium alloy coated with octacalcium phosphate and hydroxyapatite10.1016/j.actbio.2014.09.026 ↗
32. Influence of biodegradable polymer coatings on corrosion, cytocompatibility and cell functionality of Mg-2.0Zn-0.98Mn magnesium alloy10.1016/j.colsurfb.2016.04.021 ↗
33. Improvement of the biodegradation property and biomineralization ability of magnesium–hydroxyapatite composites with dicalcium phosphate dihydrate and hydroxyapatite coatings10.1021/acsbiomaterials.6b00013 ↗
34. Anticorrosive self-assembled hybrid alkylsilane coatings for resorbable magnesium metal devices10.1021/acsbiomaterials.6b00585 ↗
35. Mg and mg alloys: How comparable are in vitro and in vivo corrosion rates? A review10.1016/j.actbio.2014.11.048 ↗
36. Rates of in vivo (arterial) and in vitro biocorrosion for pure magnesium10.1002/jbm.a.35179 ↗
37. Development of a wearable bioartificial kidney using the bioartificial renal epithelial cell system (BRECS)10.1002/term.2206 ↗
38. In vitro and in vivo comparison of binary Mg alloys and pure Mg10.1016/j.msec.2015.12.064 ↗
39. Flow-induced corrosion of absorbable magnesium alloy: In-situ and real-time electrochemical study10.1016/j.corsci.2015.12.020 ↗
40. Hayes, B.K. (2016). Standardized guidance for the preclinical evaluation of absorbable metal implants. Magnesium Technology 2016, Springer.10.1002/9781119274803.ch69 ↗
41. (2018). ASTM F3268 Standard Guide for in vitro Degradation Testing of Absorbable Metals, ASTM International.
42. (2018). ISO/DTS 37137-1 Biological Evaluation of Medical Devices–Part 1: Guidance for Absorbable Implants, International Organization for Standardization.
43. (2018). ISO/DTR 37137-2 Biological Evaluation of Medical Devices–Part 2: Guidance for Absorbable Metal Implants, International Organization for Standardization.
44. Biomolecular strategies to modulate the macrophage response to implanted materials10.1039/C5TB01605C ↗
45. Yu, T., Tutwiler, V.J., and Spiller, K. (2015). The role of macrophages in the foreign body response to implanted biomaterials. Biomaterials in Regenerative Medicine and the Immune System, Springer.10.1007/978-3-319-18045-8_2 ↗
46. Eliaz, N. (2012). Biodegradable metals. Degradation of Implant Materials, Springer New York.10.1007/978-1-4614-3942-4 ↗
47. Influence of aggressive ions on the degradation behavior of biomedical magnesium alloy in physiological environment10.1016/j.actbio.2008.05.014 ↗
48. Effect of inorganic salts, amino acids and proteins on the degradation of pure magnesium in vitro10.1016/j.msec.2008.12.015 ↗
49. The corrosion of pure iron in five different mediums
50. Degradation susceptibility of surgical magnesium alloy in artificial biological fluid containing albumin10.1557/jmr.2007.0241 ↗
51. Narayan, R.J. (2017). 2–Monitoring degradation products and metal ions in vivo. Monitoring and Evaluation of Biomaterials and Their Performance In Vivo, Woodhead Publishing.
52. Evidences of in vivo bioactivity of Fe-bioceramic composites for temporary bone implants10.1002/jbm.b.33315 ↗
53. Loss of mechanical properties in vivo and bone–implant interface strength of AZ31B magnesium alloy screws with Si-containing coating10.1016/j.actbio.2013.12.020 ↗
54. Mechanical and corrosion properties of partially degradable bone screws made of pure iron and stainless steel 316l by friction welding10.1007/s40843-017-9057-3 ↗
55. Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy10.1073/pnas.1518238113 ↗
56. Turyanskaya, A., Rauwolf, M., Grünewald, A.T., Meischel, M., Stanzl-Tschegg, S., Löffler, F.J., Wobrauschek, P., Weinberg, M.A., Lichtenegger, C.H., and Streli, C. (2016). µXRF elemental mapping of bioresorbable magnesium-based implants in bone. Materials, 9.10.3390/ma9100811 ↗
57. Distribution of Fe-based degradable materials in mice skeletal muscle
58. Histological and molecular evaluation of iron as degradable medical implant material in a murine animal model10.1002/jbm.a.34223 ↗
59. In vitro and in vivo degradation evaluation of novel iron-bioceramic composites for bone implant applications10.1016/j.msec.2013.12.022 ↗
60. The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats
61. In vivo degradation behavior of the magnesium alloy LANd442 in rabbit tibiae10.3390/ma4122197 ↗
62. Profound differences in the in-vivo-degradation and biocompatibility of two very similar rare-earth containing Mg-alloys in a rabbit model10.1002/mawe.201000709 ↗
63. Site-dependent osseointegration of biodegradable high-purity magnesium for orthopedic implants in femoral shaft and femoral condyle of new zealand rabbits10.1016/j.jmst.2016.03.012 ↗
64. National Institute of Biomedical Imaging and Bioengineering (NIBIB) (2019, April 25). Magnetic Resonance Imaging (MRI), Available online: https://www.nibib.nih.gov/science-education/science-topics/magnetic-resonance-imaging-mri.
65. Sonnow, L., Könneker, S., Vogt, P.M., Wacker, F., and von Falck, C. (2017). Biodegradable magnesium herbert screw–image quality and artifacts with radiography, CT and MRI. BMC Med. Imaging, 17.10.1186/s12880-017-0187-7 ↗
66. Franklin, R.K. (2010). In Vivo Electrochemical Sensors. [Ph.D. Thesis, The University of Michigan].
67. A system for characterizing Mg corrosion in aqueous solutions using electrochemcal sensors and impedance spectroscopy10.1016/j.actbio.2013.07.011 ↗
68. In vivo electrical bioimpedance characterization of human lung tissue during the bronschoscopy proseduce. A feasibility study10.1016/j.medengphy.2012.09.004 ↗
69. Williams, B.J. (2011). Applications of Electrochemical Impedance Spectroscopy In In Vivo Corrosion Monitoring and Tissue Discrimination. [Master’s Thesis, University of Cincinnati].
70. Applications of electrochemical impedance spectroscopy in in vivo corrosion monitoring and tissue discrimination
71. In vivo monitoring the biodegradation of magnesium alloys with an electrochemical H2 sensor10.1016/j.actbio.2016.03.039 ↗
72. Visual H2 sensor for monitoring biodegradation of magnesium implants in vivo10.1016/j.actbio.2016.08.049 ↗
73. In vivo characterization of magnesium alloy biodegradation using electrochemical H2 monitoring, ICP-MS, and XPS10.1016/j.actbio.2017.01.024 ↗
74. Monitoring biodegradation of magnesium implants with sensors10.1007/s11837-015-1775-z ↗
75. Towards biodegradable wireless implants10.1098/rsta.2011.0439 ↗
76. Characterization of miniaturized RLC resonators made of biodegradable materials for wireless implant applications10.1016/j.sna.2012.08.039 ↗
77. Toward real-time continuous brain glucose and oxygen monitoring with a smart catheter10.1016/j.bios.2009.06.032 ↗
78. In vivo “real-time” monitoring of glucose in the brain with an amperometric enzyme-based biosensor based on gold coated tungsten (W-Au) microelectrodes10.1016/j.snb.2018.02.116 ↗
79. In integrated glucose sensor with an all-solid-state sodium ion-selective electrode for a minimally invasive glucose monitoring system10.3390/mi6070831 ↗
80. Microneedle-based biosensor for minimally-invasive lactate detection10.1016/j.bios.2018.08.010 ↗
81. Ex vivo examination of the biocompatibility of biodegradable magnesium via microdialysis in the isolated perfused bovine udder model10.5301/IJAO.2011.6332 ↗
82. Investigation of corrosion behavior of biodegradable magnesium alloys using an online-micro-flow capillary flow injection inductively coupled plasma mass spectrometry setup with electrochemical control10.1016/j.sab.2011.04.009 ↗
83. Monitoring magnesium degradation using microdialysis and fabric-based biosensors10.1007/s40843-017-9069-3 ↗
84. Metallic biomaterials in skeletal repair10.1007/s00068-006-6041-1 ↗
85. Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women10.2106/JBJS.J.01379 ↗
86. Serum levels of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-1 to-6 and their relationship to bone metabolism in osteoporosis patients10.1016/S0953-6205(02)00183-8 ↗
87. Body fluid proteomics for biomarker discovery: Lessons from the past hold the key to success in the future10.1021/pr070529w ↗