Electrochemical Detection of Dopamine Based on Functionalized Electrodes
Source abstract
Abstract
The rapid electrochemical identification and quantification of neurotransmitters being a challenge in the ever-growing field of neuroelectronics, we aimed to facilitate the electrochemical selective detection of dopamine by functionalizing commercially available electrodes through the deposition of a thin film containing pre-formed gold nanoparticles. The influence of different parameters and experimental conditions, such as buffer solution, fiber material, concentration, and cyclic voltammetry (CV) cycle number, were tested during neurotransmitter detection. In each case, without drastically changing the outcome of the functionalization process, the selectivity towards dopamine was improved. The detected oxidation current for dopamine was increased by 92%, while ascorbic acid and serotonin oxidation currents were lowered by 66% under the best conditions. Moreover, dopamine sensing was successfully achieved in tandem with home-made triple electrodes and an in-house built potentiostat at a high scan rate mode.
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Research context
OpenAlex topics: Electrochemical sensors and biosensors · Electrochemical Analysis and Applications · Conducting polymers and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
CUO-Recherche, Centre de recherche du CHU de Québec, Hôpital du Saint-Sacrement, Département d’ophtalmologie, Faculté de médecine, Université Laval, Québec, QC G3K 1A3, Canada
Electrical and Computer Engineering Department, Faculty of Sciences and Engineering, Université Laval, Québec, QC G1V 0A6, Canada
Funding
Natural Sciences and Engineering Research Council of Canada · Fondation des Maladies de l'Oeil · CHU de Quebec Foundation · Fonds de Recherche du Québec - Santé · Antoine Turmel Foundation. · Discovery and CMC microsystems’ Micro-Nano Technologies program · Microsystems Strategic Alliance of Quebec · Canadian Institutes of Health Research
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