Biocompatibility of Niobium Coatings
Source abstract
Abstract
Niobium coatings deposited by magnetron sputtering were evaluated as a possible surface modification for stainless steel (SS) substrates in biomedical implants. The Nb coatings were deposited on 15 mm diameter stainless steel substrates having an average surface roughness of 2 mm. To evaluate the biocompatibility of the coatings three different in vitro tests, using human alveolar bone derived cells, were performed: cellular adhesion, proliferation and viability. Stainless steel substrates and tissue culture plastic were also studied, in order to give comparative information. No toxic response was observed for any of the surfaces, indicating that the Nb coatings act as a biocompatible, bioinert material. Cell morphology was also studied by immune-fluorescence and the results confirmed the healthy state of the cells on the Nb surface. X-ray diffraction analysis of the coating shows that the film is polycrystalline with a body centered cubic structure. The surface composition and corrosion resistance of both the substrate and the Nb coating were also studied by X-ray photoelectron spectroscopy and potentiodynamic tests. Water contact angle measurements showed that the Nb surface is more hydrophobic than the SS substrate.
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Research context
OpenAlex topics: Metal and Thin Film Mechanics · Corrosion Behavior and Inhibition · Hydrogen embrittlement and corrosion behaviors in metals
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
Unidad de Materiales, Departamento de Ingeniería Mecánica y Mecátronica, Avenida 30 No. 45-03, Ciudad Unversitaria, Bototá D.C., Colombia
Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito exterior SN, Ciudad Universitaria, 04510 México DF, México
References (33)
Show source-provided references
1. Corrosion of metal orthopaedic implants10.2106/00004623-199802000-00015 ↗
2. Biological test of dental biomaterials, effect of pure metals upon the mouse subcutaneous fibroblast, strain L cell in tissue cultura
3. Steinemann, S.G. (1980). Corrosion of Surgical Implants—In vivo and in vitro Tests, Evaluation of Biomaterials, Wiley.
4. Biocompatibility and osteogenesis of refractoy metal implants, titanium, hafnium, niobium, tantalum and rhenium10.1016/S0142-9612(00)00275-1 ↗
5. The proliferation and phenotypic expression of human osteoblasts on tantalum metal10.1016/j.biomaterials.2003.09.005 ↗
6. Tissue response to porous tantalum acetabular cups: A canine model10.1016/S0883-5403(99)90062-1 ↗
7. Joint replacement components made of hot-forged and surface treated Ti-6Al-7Nb alloy10.1016/0142-9612(92)90018-J ↗
8. Histological response to cylinders of a low modulus Titanium alloy (Ti-13Nb-13Zr) and a wear resistant Zirconium alloy (Zr-2.5Nb) implanted in the rabbit tibia10.1002/jab.770040407 ↗
9. The influence of niobium and vanadium on passivity of titanium-based implants in physiological solution10.1016/S0142-9612(03)00252-7 ↗
10. Biocompatibility of β-stabilizing elements of titanium alloys10.1016/j.biomaterials.2004.01.021 ↗
11. Biomedical surface science: Foundations to frontiers10.1016/S0039-6028(01)01587-4 ↗
12. Biological surface science10.1016/S0039-6028(01)01809-X ↗
13. Surface modifications of polymers: Chemical, biological and surface analytical challenges10.1016/0956-5663(95)99218-A ↗
14. Smith, D.L. (1995). Thin Film Deposition: Principles and Practice, Mc Graw-Hill.
15. Current industrial practice critical issue in hard PVD and PA-CVD coatings10.1016/S0257-8972(96)03119-2 ↗
16. Recent developments in plasma assisted physical vapour deposition
17. Wise, D.L., Trantolo, D.J., Altobelli, D.E., Yaszemski, M.J., and Schwartz, E.R. (1995). Encyclopedic Handbook of Biomaterials and Bioengineering, Part B: Applications, Marcel Dekker.
18. Improving the biocompatibility of medical implants with plasma inmersion ion implantation10.1016/S0257-8972(02)00085-3 ↗
19. Plasma-surface modification of biomaterials10.1016/S0927-796X(02)00004-9 ↗
20. Cell culture methods for testing biocompatibility10.1016/0267-6605(94)90081-7 ↗
21. In vitro testing of surface-modified biomaterials
22. Testing biomaterials by in-situ evaluation of cell response10.1016/S1389-0344(02)00030-8 ↗
23. Comparative study of niobium nitride coatings deposited by unbalanced and balanced magnetron sputtering10.1016/j.tsf.2008.03.043 ↗
24. Niobium based coatings for dental implants10.1016/j.apsusc.2010.10.021 ↗
25. Corrosion of niobium in sulphuric and hydrochloric solutions at 75 and 95 °C10.1016/j.corsci.2006.05.028 ↗
26. Human endosteal osteoblastic cells: Relationship with bone formation10.1007/BF03354642 ↗
27. A scanning electron microscopy study of human osteoblast morphology on five orthopedic metals10.1002/jbm.10185 ↗
28. The titanium surface texture effects adherence and growth of human gingival keratinocytes and human maxillar osteoblast-like cells in vitro.10.1016/S0142-9612(01)00024-2 ↗
29. Effect of grooved titanium substratum on human osteoblastic cell growth10.1002/jbm.10101 ↗
30. Unbalanced magnetic field configuration: Plasma and film properties
31. (2000). Annual Book of ASTM standards, 3, 02 Wear and Erosion; metal Corrosion.
32. Corrosion resistance of ZrN films on AISI 304 stainless steel substrate10.1016/S0257-8972(02)00882-4 ↗
33. Properties of carbon films and their biocompatibility using in vitro tests10.1016/S0925-9635(02)00217-0 ↗